https://doi.org/10.4081/monaldi.2021.1704

Depression and anxiety symptoms among people with rifampicin-resistant tuberculosis receiving in-patient care in the National Pulmonology Reference Institute in Romania

Vol. 91 No. 1 (2021)
Published: January 14, 2021
Tuberculosis, drug-resistance, HADS, depression, anxiety
Abstract Views: 1436
PDF: 811
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Authors

Alexandru Stoichita
dr.alexandru.stoichita@gmail.com
National Institute of Pneumophtisiology “Marius Nasta”, Bucharest, Romania.
Andreea Dumitrescu
National Institute of Pneumophtisiology “Marius Nasta”, Bucharest, Romania.
Ana Ciobanu
World Health Organization, Regional Office for Europe, Copenhagen, Denmark.
Cristian Oancea
https://orcid.org/0000-0003-2083-0581
University of Medicine and Pharmacy” Victor Babes”, Timisoara, Romania.
Fildan Petronela
Faculty of Medicine “Ovidius”, University of Constanta, Romania.
Radu Dabja
University of Medicine and Pharmacy” Prof. Dr. Grigore T. Popa”, Iasi, Romania.
Kostyantyn Dumchev
https://orcid.org/0000-0003-2862-4977
Ukrainian Institute on Public Health, Kyiv, Ukraine.
Andrei Dadu
World Health Organization, Regional Office for Europe, Copenhagen, Denmark.
Beatrice Mahler-Boca
National Institute of Pneumophtisiology “Marius Nasta”, Bucharest, Romania.
Kristina Akopyan
https://orcid.org/0000-0003-0177-1870
Tuberculosis Research and Prevention Center NGO, Yerevan, Armenia.

Mental health comorbidities are common among tuberculosis patients, with higher prevalence among people with rifampicin-resistant/multidrug-resistant (RR/MDR) tuberculosis.  TB and depression share common risk factors adding to the overall disease burden. There is limited evidence about prevalence of depression and anxiety symptoms among tuberculosis patients in Romania. We assessed the prevalence of depression and anxiety symptoms and their evolution over the course of the treatment in RR/MDR-TB patients receiving in-patient care at the National Institute of Pneumonology (NIP) “Marius Nasta†in Romania during May-September 2020. We conducted a cohort study and used the Hospital Anxiety and Depression Scale (HADS) to assess the prevalence of depression and anxiety (defined as score≥ 8) symptoms at admission (baseline) and the second month of in-patient treatment (follow-up). Difference between baseline and follow-up depression and anxiety symptoms were assessed using McNemar test. Binary logistic regression was used to evaluate the association between sociodemographic and clinical characteristics with the presence of depression and anxiety symptoms at baseline. The cohort included 46 patients, 63% were male, mean age was 46 (±13.3) years. The prevalence of depression and anxiety in our cohort was 46% and 43% at baseline respectively, and 50% and 39%, at the follow-up respectively. About one third (7/25) of patients who had normal HADS depression score at baseline, had an increase above the threshold at the second month of treatment. No statistical difference in prevalence of depression or anxiety was found between the baseline and second month of treatment. Unadjusted analysis showed that odds of depression at baseline was lower in patients with education above 8th grade compared to patients with education below 8th grade (odds ratio=0.2, 95% confidence interval: 0.1,0.8, p=0.026). The study revealed high prevalence of depression and anxiety among RR/MDR-TB patients admitted to the NIP, underlining the necessity of evaluating the mental health of TB patients and linking them to appropriate care.

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Kristina Akopyan, Tuberculosis Research and Prevention Center NGO, Yerevan

Center for Infectious Diseases, Yerevan, Armenia

How to Cite

Stoichita, Alexandru, Andreea Dumitrescu, Ana Ciobanu, Cristian Oancea, Fildan Petronela, Radu Dabja, Kostyantyn Dumchev, Andrei Dadu, Beatrice Mahler-Boca, and Kristina Akopyan. 2021. “Depression and Anxiety Symptoms Among People With Rifampicin-Resistant Tuberculosis Receiving in-Patient Care in the National Pulmonology Reference Institute in Romania”. Monaldi Archives for Chest Disease 91 (1). https://doi.org/10.4081/monaldi.2021.1704.

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