https://doi.org/10.4081/monaldi.2021.1708

COVID-19: the difference between the nose and the lung

Vol. 91 No. 2 (2021)
Published: March 5, 2021
COVID-19, nose, bronchi, lung, epithelial cell
Abstract Views: 1144
PDF: 564
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Authors

Matteo Gelardi
Department of Otolaryngology, University of Foggia, Italy.
Mario Notargiacomo
Otorhinolaryngology Unit, Melzo Hospital, Milan, Italy.
Eleonora Maria Consiglia Trecca
https://orcid.org/0000-0001-6490-1746
Department of Otolaryngology, University of Foggia, Italy.
Michele Cassano
Department of Otolaryngology, University of Foggia, Italy.
Giorgio Ciprandi
gio.cip@libero.it
https://orcid.org/0000-0001-7016-8421
Allergy Clinic, Casa di Cura Villa Montallegro, Genoa, Italy.

To the Editor

An elegant study reported dysmorphic cells and syncytia in the deceased's lungs for COVID-19. The authors reasonably considered that most of these syncytia-forming cells were pneumocytes, as identified by specific biomarkers. However, cellular dysmorphism and syncytia are pathological features common in other respiratory infections caused by different viruses, including the human respiratory syncytial virus (HRSV) and Epstein-Barr virus (EBV), as correctly documented... 

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Citations

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Bussani R, Schneider E, Zentilin L, et al. Persistence of viral RNA, pneumocyte syncytia and thrombosis are hallmarks of advanced COVID-19 pathology. EBioMedicine 2020;61:103104. DOI: https://doi.org/10.1016/j.ebiom.2020.103104
Gagliardi TB, Ferreira Criado M, Proenca-Modena JL, et al. Syncytia induction by clinical isolates of human respiratory syncytial virus A. Intervirology 2017;60:56-60. DOI: https://doi.org/10.1159/000480014
Gelardi M, Tomaiuolo M, Cassano M, et al. Epstein-Barr virus induced cellular changes in nasal mucosa. Virology J 2006;3:6. DOI: https://doi.org/10.1186/1743-422X-3-6
Gelardi M, Ciprandi G. Ciliocytophthoria of nasal epithelial cells after viral infection: a sign of suffering cell. Acta Biomed 2019;90:7-9.
Gelardi M, Notargiacomo M, Trecca EMC, Cassano M. SARS-CoV-2: Naso-bronchial cytological correlations. Am J Otolaryngol 2020;41:102549. DOI: https://doi.org/10.1016/j.amjoto.2020.102549

How to Cite

Gelardi, Matteo, Mario Notargiacomo, Eleonora Maria Consiglia Trecca, Michele Cassano, and Giorgio Ciprandi. 2021. “COVID-19: The Difference Between the Nose and the Lung”. Monaldi Archives for Chest Disease 91 (2). https://doi.org/10.4081/monaldi.2021.1708.
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