https://doi.org/10.4081/monaldi.2021.1739
Bleeding events in COVID-19: the other side of the coin?
Submitted: December 15, 2020
Accepted: February 28, 2021
Published: April 1, 2021
Accepted: February 28, 2021
Abstract Views: 3031
PDF: 505
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
We present three cases of patients affected by severe SARS-CoV-2-related pneumonia treated with a low molecular weight heparin for prevention or treatment of pulmonary embolism, who presented a major bleed, in particular an ileopsoas haematoma that caused severe anaemia; in one case it was fatal. In the recent outbreak of novel coronavirus infection, significantly abnormal coagulation parameters in SARS-CoV-2 infection occur very often, but complications in the opposite direction such as bleeding diathesis are very rare. In these cases, there are different levels of gravity: for one patient the major bleed required the anticoagulant therapy to be stopped until bleeding stabilized, one patient needed interventional radiology and one patient died.
Richmann DD, Whitley RJ, Hayden FG, eds. Clinical virology, 4th ed. Washington: ASM Press; 2016.
DOI: https://doi.org/10.1128/9781555819439
Tang N, Li D, Wang X, et al. Abnormal coagulation parameters are associated with poor prognosis in patient with novel coronavirus pneumonia. J Thromb Haemost 2020;18:844-7.
DOI: https://doi.org/10.1111/jth.14768
Wang T, Chen R, Liu C, et al. Attention should be paid to venous thromboembolism prophylaxis in the management of COVID-19. Lancet Haematol 2020;7:e362-3.
DOI: https://doi.org/10.1016/S2352-3026(20)30109-5
Marquardt G, Barduzal Angles S, Leheta F, et al. Spontaneous haematoma of the iliac psoas muscle: a case report and review of the literature. Arch Orthop Trauma Surg 2002;122:109-11.
DOI: https://doi.org/10.1007/s004020100310
Ciceri F, Beretta L, Scandroglio AM. Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis. Crit Care Resusc 2020;22:95-7.
Al-Samkari H, Karp Leaf RS, Dzik WH, et al. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood 2020;136:489–500.
DOI: https://doi.org/10.1182/blood.2020006520
Taylor FB Jr, Toh CH, Hoots WK, et al. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 2001;86:1327-30.
DOI: https://doi.org/10.1055/s-0037-1616068
Li Y, Zhao K, Wei H, et al. Dynamic relationship between D-dimer and COVID-19 severity. Br J Haematol 2020;190:e24-7.
DOI: https://doi.org/10.1111/bjh.16811
Palumbo D, Guazzarotti G, De Cobelli F. Spontaneous major hemorrhage in COVID-19 patients: Another brick in the wall of SARS-CoV-2-associated coagulation disorders? J Vasc Interv Radiol 2020;31:1494-6.
DOI: https://doi.org/10.1016/j.jvir.2020.06.010
Conti CB, Henchi S, Coppeta GP, et al. Bleeding in COVID-19 severe pneumonia: The other side of abnormal coagulation pattern? Eur J Intern Med 2020;77:147-9.
DOI: https://doi.org/10.1016/j.ejim.2020.05.002
How to Cite
Coppola, Antonietta, Anna Annunziata, Maria Rosaria Gioia, and Giuseppe Fiorentino. 2021. “Bleeding Events in COVID-19: The Other Side of the Coin?”. Monaldi Archives for Chest Disease 91 (3). https://doi.org/10.4081/monaldi.2021.1739.
Copyright (c) 2021 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Matteo Petroncini, Leonardo Valentini, Piergiorgio Solli, Pietro Bertoglio, Giant lung bulla as a late-onset complication of mild SARS-CoV-2 pneumonia , Monaldi Archives for Chest Disease: Vol. 94 No. 3 (2024)
- Bruno Amato, Mario Santoro, Giuseppe Giugliano, Giuseppe Servillo, Veronica Di Nardo, Lorenza Di Domenico, Rita Compagna, Raffaele Izzo, Outcomes after non-cardiac surgery: Mortality, complications, disability, and rehospitalization , Monaldi Archives for Chest Disease: Vol. 87 No. 2 (2017)
- Carlo Iadevaia, Fabio Perrotta, Grazia Mazzeo, Francesco Saverio Cerqua, Gennaro Mazzarella, Salvatore Guarino, Roberto Parrella, Andrea Bianco, Incidental diagnosis of lung adenocarcinoma following coronavirus OC 43 severe pneumonia , Monaldi Archives for Chest Disease: Vol. 90 No. 3 (2020)
- Michele Vitacca, Piero Ceriana, Bruno Balbi , Claudio Bruschi, Maria Aliani, Mauro Maniscalco, Francesco Fanfulla, Aldo Diasparra, Luigino Rizzello, Daniela Sereni, Antonio Spanevello, The respiratory rehabilitation Maugeri network service reconfiguration after 1 year of COVID-19 , Monaldi Archives for Chest Disease: Vol. 91 No. 4 (2021)
- Stefania Angela Di Fusco, Furio Colivicchi, Nadia Aspromonte, Marco Tubaro, Alessandro Aiello, Massimo Santini, Direct oral anticoagulants in patients undergoing cardioversion: insight from randomized clinical trials , Monaldi Archives for Chest Disease: Vol. 87 No. 1 (2017)
- Ravi Manglani, Moshe Fenster, Theresa Henson, Ananth Jain, Neil Schluger, Clinical characteristics, imaging, and lung function among patients with persistent dyspnea of COVID-19: a retrospective observational cohort study , Monaldi Archives for Chest Disease: Early Access
- Astha Guliani, Abhishek Tandon, Amartya Chakroborty, Prem Parkash Gupta, Predictors of post COVID complications in patients admitted with moderate to severe COVID symptoms: A single center, prospective, observational study , Monaldi Archives for Chest Disease: Vol. 93 No. 2 (2023)
- Elpida Skouvaklidou, Ioannis Neofytou, Maria Kipourou, Konstantinos Katsoulis, Persistent unilateral diaphragmatic paralysis in the course of Coronavirus Disease 2019 pneumonia: a case report , Monaldi Archives for Chest Disease: Vol. 93 No. 4 (2023)
- Manas Pratim Roy, Risk factors for Covid-19 in India , Monaldi Archives for Chest Disease: Vol. 92 No. 2 (2022)
- Francesco Orso, Riccardo Barucci, Stefania Fracchia, Giulio Mannarino, Alessandra Pratesi, Francesco Fattirolli, Treatment of very old patients with non valvular atrial fibrillation. The valuable opportunity offered by New Oral Anticoagulants, to be cautiously used , Monaldi Archives for Chest Disease: Vol. 80 No. 4 (2013): Cardiac Series
You may also start an advanced similarity search for this article.
