Bleeding events in COVID-19: the other side of the coin?

Submitted: December 15, 2020
Accepted: February 28, 2021
Published: April 1, 2021
Abstract Views: 3031
PDF: 505
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Authors

We present three cases of patients affected by severe SARS-CoV-2-related pneumonia treated with a low molecular weight heparin for prevention or treatment of pulmonary embolism, who presented a major bleed, in particular an ileopsoas haematoma that caused severe anaemia; in one case it was fatal. In the recent outbreak of novel coronavirus infection, significantly abnormal coagulation parameters in SARS-CoV-2 infection occur very often, but complications in the opposite direction such as bleeding diathesis are very rare. In these cases, there are different levels of gravity: for one patient the major bleed required the anticoagulant therapy to be stopped until bleeding stabilized, one patient needed interventional radiology and one patient died.

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Citations

Richmann DD, Whitley RJ, Hayden FG, eds. Clinical virology, 4th ed. Washington: ASM Press; 2016. DOI: https://doi.org/10.1128/9781555819439
Tang N, Li D, Wang X, et al. Abnormal coagulation parameters are associated with poor prognosis in patient with novel coronavirus pneumonia. J Thromb Haemost 2020;18:844-7. DOI: https://doi.org/10.1111/jth.14768
Wang T, Chen R, Liu C, et al. Attention should be paid to venous thromboembolism prophylaxis in the management of COVID-19. Lancet Haematol 2020;7:e362-3. DOI: https://doi.org/10.1016/S2352-3026(20)30109-5
Marquardt G, Barduzal Angles S, Leheta F, et al. Spontaneous haematoma of the iliac psoas muscle: a case report and review of the literature. Arch Orthop Trauma Surg 2002;122:109-11. DOI: https://doi.org/10.1007/s004020100310
Ciceri F, Beretta L, Scandroglio AM. Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis. Crit Care Resusc 2020;22:95-7.
Al-Samkari H, Karp Leaf RS, Dzik WH, et al. COVID-19 and coagulation: bleeding and thrombotic manifestations of SARS-CoV-2 infection. Blood 2020;136:489–500. DOI: https://doi.org/10.1182/blood.2020006520
Taylor FB Jr, Toh CH, Hoots WK, et al. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. Thromb Haemost 2001;86:1327-30. DOI: https://doi.org/10.1055/s-0037-1616068
Li Y, Zhao K, Wei H, et al. Dynamic relationship between D-dimer and COVID-19 severity. Br J Haematol 2020;190:e24-7. DOI: https://doi.org/10.1111/bjh.16811
Palumbo D, Guazzarotti G, De Cobelli F. Spontaneous major hemorrhage in COVID-19 patients: Another brick in the wall of SARS-CoV-2-associated coagulation disorders? J Vasc Interv Radiol 2020;31:1494-6. DOI: https://doi.org/10.1016/j.jvir.2020.06.010
Conti CB, Henchi S, Coppeta GP, et al. Bleeding in COVID-19 severe pneumonia: The other side of abnormal coagulation pattern? Eur J Intern Med 2020;77:147-9. DOI: https://doi.org/10.1016/j.ejim.2020.05.002

How to Cite

Coppola, Antonietta, Anna Annunziata, Maria Rosaria Gioia, and Giuseppe Fiorentino. 2021. “Bleeding Events in COVID-19: The Other Side of the Coin?”. Monaldi Archives for Chest Disease 91 (3). https://doi.org/10.4081/monaldi.2021.1739.

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