https://doi.org/10.4081/monaldi.2021.1769
Chronic rhinosinusitis with nasal polyposis: the role of personalized and integrated medicine
Accepted: February 28, 2021
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a common disorder. From a clinical and immunopathological point of view, different phenotypes and endotypes have been identified. As asthma is frequent comorbidity, biological agents for treating CRSwNP associated with asthma may be an attractive strategy. Biological agents have several mechanisms, such as antagonizing IgE, interleukin (IL) 4, IL-5, and IL-13. However, a workup is mandatory, mainly concerning pheno-endotyping. In this regard, clinical cytological grading (CCG) has been proposed as a useful tool to manage patients with CRSwNP as it allows us to define clinical and immunopathological phenotypes able to identify the ideal candidate for biologics. In particular, the mixed cellular pattern, such as eosinophils and mast cells, could be sensitive to anti-IL-4 agents. There is still a need for well-established indications, criteria of responsiveness, duration, and safety. Moreover, personalized medicine could be opportunely integrated and/or alternated with intranasal corticosteroids to prevent relevant adverse events.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Mario Pacileo, Plinio Cirillo, Salvatore De Rosa, Grazia Ucci, Gianluca Petrillo, Sergio Musto D’Amore, Laura Sasso, Paola Maietta, Raffaele Spagnuolo, Massimo Chiariello, The role of Neopterin in cardiovascular disease , Monaldi Archives for Chest Disease: Vol. 68 No. 2 (2007): Cardiac series
- G. Valli, P. Paoletti, D. Savi, D. Martolini, P. Palange, Clinical use of Heliox in Asthma and COPD , Monaldi Archives for Chest Disease: Vol. 67 No. 3 (2007): Pulmonary series
- D.P. Tashkin, Smoked Marijuana as a Cause of Lung Injury , Monaldi Archives for Chest Disease: Vol. 63 No. 2 (2005): Pulmonary series
- C. Incorvaia, F. Frati, P. Puccinelli, G.G. Riario-Sforza, S. Dal Bo, Dose dependence of efficacy and safety of subcutaneous immunotherapy , Monaldi Archives for Chest Disease: Vol. 65 No. 1 (2006): Pulmonary series
- Ornella Bettinardi, Letizia da Vico, Antonia Pierobon, Manuela Iannucci, Barbara Maffezzoni, Silvana Borghi, Marina Ferrari, Silvia Brazzo, Antonio Mazza, Marinella Sommaruga, Elisabetta Angelino, Barbara Biffi, Susanna Agostini, Maria Luisa Masini, Marco Ambrosetti, Pompilio Faggiano, Raffaele Griffo, First definition of Minimal Care model: the role of nurses, physiotherapists, dietitians and psychologists in preventive and rehabilitative cardiology , Monaldi Archives for Chest Disease: Vol. 82 No. 3 (2014): Cardiac series
- Jyoti Kumari, Manish Advani, Gopal Purohit, Prevalence of pulmonary hypertension in chronic simple silicosis patients and its correlation with smoking history, occupation type, age and duration of silica exposure , Monaldi Archives for Chest Disease: Early Access
- Giovanni Capobianco, Cognitive impairment in patients with atrial fibrillation: What is the importance of anticoagulant therapy? , Monaldi Archives for Chest Disease: Vol. 88 No. 2 (2018)
- Michele Vitacca, Marta Lazzeri, Enrico Guffanti, Pamela Frigerio, Francesco D’Abrosca, Silvia Gianola, Mauro Carone, Mara Paneroni, Piero Ceriana, Franco Pasqua, Paolo Banfi, Francesco Gigliotti, Carla Simonelli, Serena Cirio, Veronica Rossi, Chiara G. Beccaluva, Mariangela Retucci, Martina Santambrogio, Andrea Lanza, Francesca Gallo, Alessia Fumagalli, Marco Mantero, Greta Castellini, Mariaconsiglia Calabrese, Giorgio Castellana, Eleonora Volpato, Marina Ciriello, Marina Garofano, Enrico Clini, Nicolino Ambrosino, on behalf of AIPO, ARIR, SIP, AIFI and SIFIR, An Italian consensus on pulmonary rehabilitation in COVID-19 patients recovering from acute respiratory failure: results of a Delphi process , Monaldi Archives for Chest Disease: Vol. 90 No. 2 (2020)
- Roberto F.E. Pedretti, Michele Gabriele, Sergio Masnaghetti, Pompilio Faggiano, Erectile dysfunction and cardiovascular disease: Focus on , Monaldi Archives for Chest Disease: Vol. 82 No. 2 (2014): Cardiac series
- Enrico Vizzardi, Pompilio Faggiano, Ermanna Chiari, Diego Maffeo, Silvia Frattini, Francesca Bellandi, Savina Nodari, Livio Dei Cas, The study of left ventricular diastolic function by Doppler echocardiography: the essential for the clinician , Monaldi Archives for Chest Disease: Vol. 72 No. 1 (2009): Cardiac series
<< < 12 13 14 15 16 17 18 19 20 21 > >>
You may also start an advanced similarity search for this article.
