https://doi.org/10.4081/monaldi.2022.1798
Two years progression-free survival under vinorelbine metronomic therapy of a patient with metastatic epithelioid hemangioendothelioma
Submitted: February 8, 2021
Accepted: March 30, 2022
Published: April 1, 2022
Accepted: March 30, 2022
Abstract Views: 1015
PDF: 338
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Epithelioid hemangioendothelioma (EHE) is a very rare vascular tumor, originating from endothelial cells. The etiology of EHE is unknown, yet at the molecular level, different angiogenic stimulators may act as promoters of endothelial cell proliferation. The tumor affects more commonly the lung, the liver and the bones but it can affect any other organ. Due to its heterogeneous presentation and its rarity it is often misdiagnosed. No treatment is proved to be efficient in metastatic EHE and the median survival of patients with metastatic pleural disease is generally poor, less than one year. we report a case of a 57-year-old female with multiple metastatic EHE including pleural, diagnosed by medical thoracoscopy, with a progression-free survival of 24 months with oral vinorelbine as maintenance therapy after combination of cisplatin-vinorelbine. We believe that this therapy might be of value to test in this patient population as it has never been tested before.
Dail DH, Liebow AA, Gmelich JT, et al. Intravascular, bronchiolar, and alveolar tumor of the lung (IVBAT). An analysis of twenty cases of a peculiar sclerosing endothelial tumor. Cancer 1983;51:452-64.
DOI: https://doi.org/10.1002/1097-0142(19830201)51:3<452::AID-CNCR2820510317>3.0.CO;2-M
Sardaro A, Bardoscia L, Petruzzelli MF, et al. Epithelioid hemangioendothelioma: an overview and update on a rare vascular tumor. Oncol Rev 2014;8:259.
DOI: https://doi.org/10.4081/oncol.2014.259
Weiss SW, Enzinger FM. Epithelioid hemangioendothelioma: a vascular tumor often mistaken for a carcinoma. Cancer 1982;50:970-81.
DOI: https://doi.org/10.1002/1097-0142(19820901)50:5<970::AID-CNCR2820500527>3.0.CO;2-Z
Lau K, Massad M, Pollak C, et al. Clinical patterns and outcome in epithelioid hemangioendothelioma with or without pulmonary involvement: insights from an internet registry in the study of a rare cancer. Chest 2011;140:1312-8.
DOI: https://doi.org/10.1378/chest.11-0039
Kitaichi M, Nagai S, Nishimura K, et al. Pulmonary epithelioid haemangioendothelioma in 21 patients, including three with partial spontaneous regression. Eur Respir J 1998;12:89-96.
DOI: https://doi.org/10.1183/09031936.98.12010089
Anderson T, Zhang L, Hameed M, et al. Thoracic epithelioid malignant vascular tumors: a clinicopathologic study of 52 cases with emphasis on pathologic grading and molecular studies of WWTR1-CAMTA1 fusions. Am J Surg Pathol 2015;39:132-9.
DOI: https://doi.org/10.1097/PAS.0000000000000346
Lin BT, Colby T, Gown AM, et al. Malignant vascular tumors of the serous membranes mimicking mesothelioma. A report of 14 cases. Am J Surg Pathol 1996;20:1431-9.
DOI: https://doi.org/10.1097/00000478-199612000-00001
Stacchiotti S, Provenzano S, Dagrada G, et al. Sirolimus in advanced epithelioid hemangioendothelioma: A retrospective case-series analysis from the Italian Rare Cancer Network Database. Ann Surg Oncol 2016;23:2735-44.
DOI: https://doi.org/10.1245/s10434-016-5331-z
Koch M, Nielsen GP, Yoon SS. Malignant tumors of blood vessels: angiosarcomas, hemangioendotheliomas, and hemangioperictyomas. J Surg Oncol 2008;97:321-9.
DOI: https://doi.org/10.1002/jso.20973
Gaur S, Torabi A, O'Neill TJ. Activity of angiogenesis inhibitors in metastatic epithelioid hemangioendothelioma: a case report. Cancer Biol Med 2012;9:133-6.
van der Graaf WT, Blay JY, Chawla SP, et al. Pazopanib for metastatic soft-tissue sarcoma (PALETTE): a randomised, double-blind, placebo-controlled phase 3 trial. Lancet 2012;379:1879-86.
DOI: https://doi.org/10.1016/S0140-6736(12)60651-5
Lee YJ, Chung MJ, Jeong KC, et al. Pleural epithelioid hemangioendothelioma. Yonsei Med J 2008;49:1036-40.
DOI: https://doi.org/10.3349/ymj.2008.49.6.1036
Hatzimichael E, Briasoulis E. Metronomic chemotherapy beyond misconceptions. Haematologica 2013;98:e145.
DOI: https://doi.org/10.3324/haematol.2013.096917
Mavroeidis L, Sheldon H, Briasoulis E, et al. Metronomic vinorelbine: Anti-angiogenic activity in vitro in normoxic and severe hypoxic conditions, and severe hypoxia-induced resistance to its anti-proliferative effect with reversal by Akt inhibition. Int J Oncol 2015;47:455-64.
DOI: https://doi.org/10.3892/ijo.2015.3059
Froudarakis ME, Briasoulis E. Advanced non-small cell lung cancer: on relapse rechallenge the tumor, not the patient. BMC Res Notes 2010;3:195.
DOI: https://doi.org/10.1186/1756-0500-3-195
Briasoulis E, Aravantinos G, Kouvatseas G, et al. Dose selection trial of metronomic oral vinorelbine monotherapy in patients with metastatic cancer: a hellenic cooperative oncology group clinical translational study. BMC Cancer 2013;13:263.
DOI: https://doi.org/10.1186/1471-2407-13-263
Pujol JL, Coffy A, Camerini A, et al. An individual patient-data meta-analysis of metronomic oral vinorelbine in metastatic non-small cell lung cancer. PLoS One 2019;14:e0220988.
DOI: https://doi.org/10.1371/journal.pone.0220988
How to Cite
Anevlavis, Stavros, Georgia Karpathiou, Paschalis Ntolios, and Marios E. Froudarakis. 2022. “Two Years Progression-Free Survival under Vinorelbine Metronomic Therapy of a Patient With Metastatic Epithelioid Hemangioendothelioma”. Monaldi Archives for Chest Disease 92 (4). https://doi.org/10.4081/monaldi.2022.1798.
Copyright (c) 2022 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Ana Isabel Pinho, Cátia Oliveira, Luís Daniel Santos, Catarina Marques, André Cabrita, Paula Dias, Gonçalo Pestana, Carla Sousa, Rui André Rodrigues, Authors’ Response , Monaldi Archives for Chest Disease: Early Access
- Chiara Sordelli, Raffaele Verde, Nunzia Fele, Sara Hana Weisz, Laura Severino, Alessandro Perrella, Angela Guarino, Emilio Di Lorenzo, Sergio Severino, A case of a huge aortic pseudo-aneurysm following aortic bioprosthetic endocarditis: the key role of 3D echocardiography , Monaldi Archives for Chest Disease: Early Access
- Igor S. Mamenko, Igor V. Vasilev, Irina A. Tabanakova, Sultan M. Gasanmagomedov, Vera V. Sysoeva, Alexey D. Ushkov, Tatiana A. Novickaya, Piotr K. Yablonskii, Probe-based confocal laser endomicroscopy in diagnosis of desquamative interstitial pneumonia in nonsmoker , Monaldi Archives for Chest Disease: Vol. 89 No. 3 (2019)
- Ugo Corrà , Massimo Pistono, Early mobilization in LVAD recipients: An obligatory step towards recovery , Monaldi Archives for Chest Disease: Vol. 89 No. 1 (2019)
- Anna Comba, Alessandra Ardizzone, Laura Leto, Mauro Feola, Impact of a nutrition/educational program in a group of type 2 diabetes patients, already involved in a wider "Group Care" plan and not achieving complete target: an observational study , Monaldi Archives for Chest Disease: Vol. 87 No. 1 (2017)
- Marie Christine Iliou, Jean Christophe Blanchard, Aurélia Lamar-Tanguy, Pascal Cristofini, François Ledru, Cardiac rehabilitation in patients with pacemakers and implantable cardioverter defibrillators , Monaldi Archives for Chest Disease: Vol. 86 No. 1-2 (2016): Cardiac series
- Manuel Monti, Management of severe Falciparum malaria on a mission: A case report , Monaldi Archives for Chest Disease: Vol. 89 No. 1 (2019)
- Francesco Antonini-Canterin, Concetta Di Nora, Marco Pellegrinet, Olga Vriz, Salvatore La Carrubba, Scipione Carerj, Concetta Zito, Anca Matescu, Andreea Ravasel, Iulian Cosei, Bogdan A. Popescu, Effect of uric acid serum levels on carotid arterial stiffness and intima-media thickness: A high resolution Echo-Tracking Study , Monaldi Archives for Chest Disease: Vol. 89 No. 1 (2019)
- Roberto Torchio, Alessandra Mazzucco, Marco Guglielmo, Roberto Giardino, Claudio Ciacco, Francesco Ardissone, Minute ventilation to carbon dioxide output (V’E/V’CO2 slope) is the strongest death predictor before larger lung resections , Monaldi Archives for Chest Disease: Vol. 87 No. 3 (2017)
You may also start an advanced similarity search for this article.
