https://doi.org/10.4081/monaldi.2021.1814
Post tuberculosis radiological sequelae in patients treated for pulmonary and pleural tuberculosis at a tertiary center in Pakistan
Submitted: March 1, 2021
Accepted: July 13, 2021
Published: August 2, 2021
Accepted: July 13, 2021
Abstract Views: 2236
PDF: 1109
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Treating tuberculosis (TB) is not the end of the disease because of the wide spectrum of post TB sequelae associated with the disease. There is insufficient data on post TB radiological sequelae. The aim of this study is to evaluate the post TB radiological sequelae on chest x-rays in patients who had completed the treatment for pulmonary and pleural TB at a tertiary care hospital of a high TB burden country. This is a retrospective cross-sectional study conducted on patients treated for pulmonary and pleural TB. Adult patients (18 years or above) with a clinical or microbiological diagnosis of pulmonary or pleural TB were included. Patients were classified on the basis of site of TB into pulmonary and pleural TB. Post-treatment radiological sequelae on chest x-ray were evaluated and divided into three main types i.e. fibrosis, bronchiectasis and pleural thickening. During the study period a total of 321 patients were included with a mean age of 44(SD±19) years. Only 17.13% (n=55) patients had normal chest x-rays at the end of treatment and 82.87% (n=266) patients had post-TB radiological sequelae with fibrosis being the most common followed by pleural thickening. The post TB radiological sequelae were high in patients who had diabetes mellitus (78.94%), AFB smear-positive (90.19%), AFB culture-positive (89.84%), Xpert MTB/Rif positive (88.40%) and with drug-resistant TB (100%). As a clinician, one should be aware of all the post TB sequelae so that early diagnosis and management can be facilitated.
World Health Organization. Global tuberculosis report 2018: World Health Organization; 2018.
Khan R, Malik NI, Razaque AJP. Imaging of pulmonary post-tuberculosis sequelae. Pak J Med Sci 2020;36:S75.
DOI: https://doi.org/10.12669/pjms.36.ICON-Suppl.1722
Menon B, Nima G, Dogra V, Jha S. Evaluation of the radiological sequelae after treatment completion in new cases of pulmonary, pleural, and mediastinal tuberculosis. Lung India 2015;32:241-5.
DOI: https://doi.org/10.4103/0970-2113.156233
Singla R, Mallick M, Mrigpuri P, et al. Sequelae of pulmonary multidrug-resistant tuberculosis at the completion of treatment. Lung India 2018;35:4-8.
DOI: https://doi.org/10.4103/lungindia.lungindia_269_16
Proschek P, Vogl TJ. Chest and mediastinum. In: T Vogl, W Reith, E Rummeny, Editors. Diagnostic and Interventional Radiology. Berlin: Springer; 2015. p. 479-587.
DOI: https://doi.org/10.1007/978-3-662-44037-7_19
Stark P. Imaging in Pulmonary Disease. In: L Goldman, A Schafer, Editors. Goldman's Cecil medicine. Amsterdam: Elsevier; 2012. Chapter 84.
Meghji J, Simpson H, Squire SB, Mortimer K. A systematic review of the prevalence and pattern of imaging defined post-TB lung disease. PLoS One 2016;11:e0161176.
DOI: https://doi.org/10.1371/journal.pone.0161176
Rajeswari R, Muniyandi M, Balasubramanian R, Narayanan PR. Perceptions of tuberculosis patients about their physical, mental and social well-being: a field report from south India. Soc Sci Med 2005;60:1845-53.
DOI: https://doi.org/10.1016/j.socscimed.2004.08.024
Shah M, Reed C. Complications of tuberculosis. Curr Opin Infect Dis 2014;27:403-10.
DOI: https://doi.org/10.1097/QCO.0000000000000090
Satya SS. Textbook of pulmonary and extra pulmonary tuberculosis. Mehta Publishers; 2009.
Deshpande SS, Joshi AR, Shah AJP. Aftermath of pulmonary tuberculosis: computed tomography assessment. Pol J Radiol 2020;85:e144-54.
DOI: https://doi.org/10.5114/pjr.2020.93714
Singla N, Singla R, Fernandes S, Behera D. Post treatment sequelae of multi-drug resistant tuberculosis patients. Indian J Tubercul 2009;56:206-12.
Barker AF. Bronchiectasis. N Engl J Med. 2002;346:1383-93.
DOI: https://doi.org/10.1056/NEJMra012519
Bhatta N, Dhakal S, Rizal S, et al. Clinical spectrum of patients presenting with bronchiectasis in Nepal: evidence of linkage between tuberculosis, tobacco smoking and toxic exposure to biomass smoke. Kathmandu University Medical Journal (KUMJ) 2008;6:195-203.
Salkin D. Tuberculosis as a cause of upper lobe bronchiectasis. Califor Med 1950;73:577.
Shaikh MA, Singla R, Khan NB, et al. Does diabetes alter the radiological presentation of pulmonary tuberculosis. Saudi Med J 2003;24:278-81.
Patel AK, Rami KC, Ghanchi FD. Radiological presentation of patients of pulmonary tuberculosis with diabetes mellitus. Lung India 2011;28:70.
DOI: https://doi.org/10.4103/0970-2113.76308
Nihues SdSE, Mancuzo EV, Sulmonetti N, et al. Chronic symptoms and pulmonary dysfunction in post-tuberculosis Brazilian patients. Braz J Infect Dis 2015;19:492-7.
DOI: https://doi.org/10.1016/j.bjid.2015.06.005
Hsu D, Irfan M, Jabeen K, et al. Post tuberculosis treatment infectious complications. Int J Infect Dis 2020;92:S41-5.
DOI: https://doi.org/10.1016/j.ijid.2020.02.032
Denning DW, Pleuvry A, Cole DC. Global burden of chronic pulmonary aspergillosis as a sequel to pulmonary tuberculosis. Bull World Health Organ 2011;89:864-72.
DOI: https://doi.org/10.2471/BLT.11.089441
Di Naso FC, Pereira J, Schuh S, Unis G. [Functional evaluation in patients with pulmonary tuberculosis sequelae].[Article in Portuguese]. Rev Port Pneumol 2011;17:216-21.
DOI: https://doi.org/10.1016/j.rppnen.2011.06.005
Hanekom S, Pharaoh H, Irusen E, Daniels KJ. Post-tuberculosis health-related quality of life, lung function and exercise capacity in a cured pulmonary tuberculosis population in the Breede Valley District, South Africa. S Afr J Physiother 2019;75:1319.
DOI: https://doi.org/10.4102/sajp.v75i1.1319
Hnizdo E, Singh T, Churchyard G. Chronic pulmonary function impairment caused by initial and recurrent pulmonary tuberculosis following treatment. Thorax 2000;55:32-8.
DOI: https://doi.org/10.1136/thorax.55.1.32
Visca D, Centis R, D'Ambrosio L, et al. The need for pulmonary rehabilitation following tuberculosis treatment. Int J Tuberc Lung Dis 2020;24:720-2.
DOI: https://doi.org/10.5588/ijtld.20.0030
Visca D, Zampogna E, Sotgiu G, et al. Pulmonary rehabilitation is effective in patients with tuberculosis pulmonary sequelae. Eur Respir J 2019;53:1802184.
DOI: https://doi.org/10.1183/13993003.02184-2018
How to Cite
Zubair, Syed Muhammad, Mariyam Gohar Ali, and Muhammad Irfan. 2021. “Post Tuberculosis Radiological Sequelae in Patients Treated for Pulmonary and Pleural Tuberculosis at a Tertiary Center in Pakistan”. Monaldi Archives for Chest Disease 92 (1). https://doi.org/10.4081/monaldi.2021.1814.
Copyright (c) 2021 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Federico Piffer, Guido Levi, Giampietro Marchetti, Chiara Barbieri, Immune reconstitution inflammatory syndrome in tuberculous pleurisy and ulcerative colitis: a case report , Monaldi Archives for Chest Disease: Vol. 89 No. 3 (2019)
- Lucrezia De Michele, Paola Pierucci, Guido Giovannetti, Arnaldo Scardapane, Carlo D'agostino, Giovanna Elisiana Carpagnano, Authors’ response to the Letter to the Editor regarding: Post severe COVID-19 infection lung damages study. The experience of early three months multidisciplinary follow-up , Monaldi Archives for Chest Disease: Vol. 92 No. 4 (2022)
- Elias F. Porto, Antonio A.M. Castro, Daniela M Fausto, Claudia Kümpel, Ana Denise Brandão, Paula Bernardo de Lima, Jordania C. Fagundes, Brenda Zozimo, Balance impairment and lower limbs strength in patients with COPD who fell in the previous year , Monaldi Archives for Chest Disease: Vol. 92 No. 4 (2022)
- Miguel Osejo-Betancourt, Pedro Chaparro-Mutiz, Erasmus syndrome: The association of systemic sclerosis and silicosis , Monaldi Archives for Chest Disease: Vol. 93 No. 1 (2023)
- Mehmet Erdem Çakmak, Saltuk Buğra Kaya, Özge Can Bostan, Ebru Damadoğlu, Gül Karakaya, Ali Fuat Kalyoncu, Short- and long-term oral steroid therapy in patients with asthma exacerbation , Monaldi Archives for Chest Disease: Vol. 93 No. 1 (2023)
- Karina Vieira da Costa, Iara Tainá Cordeiro de Souza, João Victor dos Santos Felix, Celso Brendo Furtado Brandão, Vanessa Michelle de Souza Fernandes, Andressa Bomfim Lugon Favero, Maria Lucrécia de Aquino Gouveia, Dyego Tavares de Lima, José Heriston de Morais Lima, Rafaela Pedrosa, Tatiana Onofre, Geraldo Eduardo Guedes de Brito, Eduardo Eriko Tenorio de França, Efficacy of a rehabilitation protocol on pulmonary and respiratory muscle function and ultrasound evaluation of diaphragm and quadriceps femoris in patients with post-COVID-19 syndrome: a series of cases , Monaldi Archives for Chest Disease: Vol. 93 No. 1 (2023)
- Emanuele Stirpe, Floriana Bardaro, Alpha1-antitrypsin deficiency and asthma , Monaldi Archives for Chest Disease: Vol. 92 No. 4 (2022)
- Sam Bartlett-Pestell, James May, Ashutosh Sharma, Sunshine Alonzo, Natalie Barnes , Brendan P. Madden, A 12-year experience in endobronchial intervention using rigid bronchoscopy - account of a tertiary referral centre , Monaldi Archives for Chest Disease: Vol. 92 No. 4 (2022)
- Despoina Moumtzi, Marianna Kakoura, Pulmonary embolism in Behcet's disease: a case report , Monaldi Archives for Chest Disease: Vol. 90 No. 4 (2020)
- Pratap Upadhya, Rohit Vadala, Arpitha A, Hospital treatment of severe acute exacerbation of chronic obstructive pulmonary disease in COVID-19 situation: back to basics , Monaldi Archives for Chest Disease: Vol. 90 No. 4 (2020)
<< < 15 16 17 18 19 20 21 > >>
You may also start an advanced similarity search for this article.
