https://doi.org/10.4081/monaldi.2021.1867
Hyperimmune plasma infusion in an immunocompromised Covid-19 patient previously treated for follicular lymphoma
Submitted: March 27, 2021
Accepted: May 12, 2021
Published: June 10, 2021
Accepted: May 12, 2021
Abstract Views: 1704
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Covid-19 in immunocompromised patients shows a prolonged course and may lead to a poor prognosis. Although data on hyperimmune plasma for treatment of Covid-19 suggest an improved outcome in immunocompetent patients, limited data are currently available in immunocompromised patients. We present the case of a 62-year-old Caucasian woman, who was previously treated with obinutuzumab and bendamustine for follicular lymphoma and showed a prolonged positive test for Covid-19. Since no improvement was observed with standard of care (including remdesivir), the possibility of hyperimmune plasma infusion was discussed. A first dose of hyperimmune plasma was administered, with subsequent onset of fever, increasing inflammatory indexes and worsening radiological findings. Three days later a second dose of plasma was administered. Within twelve hours cough and fever disappeared, and oxygen at rest was discontinued. The patient was discharged 5 days later, and nasopharyngeal swabs resulted negative 16 days after discharge.
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Supporting Agencies
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Levi, Guido, Chiara Rocchetti, Roberto Magri, Silvia Uccelli, Damiano Bottone, Federico Quadri, Mauro Novali, Alessandro D. Santin, and Michela Bezzi. 2021. “Hyperimmune Plasma Infusion in an Immunocompromised Covid-19 Patient Previously Treated for Follicular Lymphoma”. Monaldi Archives for Chest Disease 91 (4). https://doi.org/10.4081/monaldi.2021.1867.
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