https://doi.org/10.4081/monaldi.2021.1878
Platypnea orthodeoxia syndrome in a patient with patent foramen ovale and normal atrial pressure. Case report and presentation of underlying pathophysiological mechanisms
Submitted: April 5, 2021
Accepted: June 13, 2021
Published: September 28, 2021
Accepted: June 13, 2021
Abstract Views: 1192
PDF: 511
Video 1: 133
Video 2: 153
Video 1: 133
Video 2: 153
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Platypnea-orthodeoxia Syndrome is characterized by clinically significant postural hypoxia. The full spectrum of the syndrome includes intracardial and extracardial abnormalities with R->L shunt. Various concurrent underlying physiological abnormalities are usually encountered that require thorough clinical and laboratory evaluation. A high clinical suspicion in patients with unexplained dyspnea is also required to reach a firm diagnosis. We herein present a rare case of an 82-years-old patient with episodic unexplained dyspnea, patent foramen ovale with normal pulmonary pressures and we review the underlying physiologic mechanisms.
Cheng TO. Platypnea-orthodeoxia syndrome: etiology, differential diagnosis, and management. Catheter Cardiovasc Interv1999;47:64-6.
DOI: https://doi.org/10.1002/(SICI)1522-726X(199905)47:1<64::AID-CCD15>3.0.CO;2-6
Agrawal A, Palkar A, Talwar A. The multiple dimensions of platypnea-orthodeoxia syndrome: A review. Respir Med 2017;129:31-8.
DOI: https://doi.org/10.1016/j.rmed.2017.05.016
Mojadidi MK, Ruiz JC, Chertoff J, et al. Patent foramen ovale and hypoxemia. Cardiol Rev 2019;27:34-40.
DOI: https://doi.org/10.1097/CRD.0000000000000205
Hagen PT, Scholz DG, Edwards WD. Incidence and size of patent foramen ovale during the first 10 decades of life: an autopsy study of 965 normal hearts. Mayo Clin Proc 1984;59:17-20.
DOI: https://doi.org/10.1016/S0025-6196(12)60336-X
Kizer JR, Devereux RB. Clinical practice. Patent foramen ovale in young adults with unexplained stroke. N Engl J Med. 2005;353:2361-72.
DOI: https://doi.org/10.1056/NEJMcp043981
Lio KU, Jiménez D, Moores L, Rali P. Clinical conundrum: concomitant high-risk pulmonary embolism and acute ischemic stroke. Emerg Radiol 2020;27:433-9.
DOI: https://doi.org/10.1007/s10140-020-01772-7
Chen GP, Goldberg SL, Gill EA, Jr. Patent foramen ovale and the platypnea-orthodeoxia syndrome. Cardiol Clin 2005;23:85-9.
DOI: https://doi.org/10.1016/j.ccl.2004.10.003
Zanchetta M, Rigatelli G, Ho SY. A mystery featuring right-to-left shunting despite normal intracardiac pressure. Chest 2005;128:998-1002.
DOI: https://doi.org/10.1378/chest.128.2.998
Pierce CW. Platypnea-orthodeoxia syndrome in an elderly woman with a patent foramen ovale. Can J Cardiol 2010;26:213-4.
DOI: https://doi.org/10.1016/S0828-282X(10)70372-X
How to Cite
Sampsonas, Fotios, Matthaios Katsaras, Ourania Papaioannou, Theodoros Karampitsakos, Lampros Lakkas, Lampros K. Michalis, and Argyrios Tzouvelekis. 2021. “Platypnea Orthodeoxia Syndrome in a Patient With Patent Foramen Ovale and Normal Atrial Pressure. Case Report and Presentation of Underlying Pathophysiological Mechanisms”. Monaldi Archives for Chest Disease 92 (1). https://doi.org/10.4081/monaldi.2021.1878.
Copyright (c) 2021 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Gabriele Valli, Francesca De Marco, Maria Teresa Spina, Valentina Valeriano, Antonello Rosa, Valentina Minerva, Enrico Mirante, Maria Pia Ruggieri, Francesco Rocco Pugliese, A pilot study on the application of the current European guidelines for the management of acute coronary syndrome without elevation of ST segment (NSTEMI) in the Emergency Department setting in the Italian region Lazio , Monaldi Archives for Chest Disease: Vol. 82 No. 4 (2014): Cardiac series
- Paola Gremigni, Cynical hostility and the metabolic syndrome: A case-control study , Monaldi Archives for Chest Disease: Vol. 66 No. 3 (2006): Cardiac series
- Panagiotis Hountis, Maria Chounti, Chilaiditi’s sign or syndrome? Diagnostic question in two patients with concurrent cardiovascular diseases , Monaldi Archives for Chest Disease: Vol. 87 No. 2 (2017)
- Muhammad Ijaz, Muhammad Jaffar Khan, Jawad Khan, . Usama, Association of clinical characteristics of patients presenting with influenza like illness or severe acute respiratory illness with development of acute respiratory distress syndrome , Monaldi Archives for Chest Disease: Vol. 87 No. 1 (2017)
- Massimiliano Polastri, Lara Pisani, Andrea Dell'Amore, Stefano Nava, Revolving door respiratory patients: A rehabilitative perspective , Monaldi Archives for Chest Disease: Vol. 87 No. 3 (2017)
- Paolo Ruggeri, Federica Lo Bello, Francesco Nucera, Michele Gaeta, Francesco Monaco, Gaetano Caramori, Giuseppe Girbino, Hereditary hyperhomocysteinemia associated with nephrotic syndrome complicated by artery thrombosis and chronic thromboembolic pulmonary hypertension: A case report , Monaldi Archives for Chest Disease: Vol. 87 No. 3 (2017)
- Edoardo Sciatti, Enrico Vizzardi, Dario S. Cani, Assunta Castiello, Ivano Bonadei, Daria Savoldi, Marco Metra, Antonio D'Aloia, Kounis syndrome, a disease to know: Case report and review of the literature , Monaldi Archives for Chest Disease: Vol. 88 No. 1 (2018)
- Costantina Prota, Rodolfo Citro, Angelo Silverio, Roberto Ascoli, Corrado Naddeo, Giovanni Vitale, Federico Piscione, Thrombus straddling a patent foramen ovale , Monaldi Archives for Chest Disease: Vol. 80 No. 3 (2013): Cardiac series
- Roberto Porta, Laura Comini, Luca Barbano, Luca Bianchi, Michele Vitacca, A case of obstructive sleep apnea syndrome associated with floppy eyelid syndrome: positive effect of CPAP therapy , Monaldi Archives for Chest Disease: Vol. 87 No. 1 (2017)
- O. Serafini, G. Misuraca, A. Siniscalchi, M.T. Manes, G. Meringolo, C. Tomaselli, M. Chiatto, A. Buffon, Prevalence of aneurysm of the interatrial septum in the general population and in patients with a recent episode of cryptogenetic ischemic stroke: a tissue harmonic imaging transthoracic ecocardiography study in 5.631 patients , Monaldi Archives for Chest Disease: Vol. 66 No. 4 (2006): Cardiac series
You may also start an advanced similarity search for this article.
