https://doi.org/10.4081/monaldi.2021.1925

Acute effect of oxygen therapy on exercise tolerance and dyspnea perception in ILD patients

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Vol. 92 No. 2 (2022)
Submitted: May 12, 2021
Accepted: September 6, 2021
Published: October 11, 2021
Interstitial lung disease, dyspnea, oxygen supplementation, 6MWT
Abstract Views: 1432
PDF: 698
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Authors

Josuel Ora
josuel78@gmail.com
https://orcid.org/0000-0001-9877-7851
Respiratory Medicine, Tor Vergata Hospital Foundation, Rome, Italy.
Angelo Coppola
Respiratory Medicine, San Filippo Neri Hospital, Rome, Italy.
Andrea Perduno
Respiratory Medicine, Department of Experimental Medicine, Tor Vergata University, Rome, Italy.
Gian Marco Manzetti
https://orcid.org/0000-0002-8265-7959
Respiratory Medicine, Department of Experimental Medicine, Tor Vergata University, Rome, Italy.
Ermanno Puxeddu
Respiratory Medicine, Tor Vergata Hospital Foundation, Rome; Respiratory Medicine, Department of Experimental Medicine, Tor Vergata University, Rome, Italy.
Paola Rogliani
Respiratory Medicine, Tor Vergata Hospital Foundation, Rome; Respiratory Medicine, Department of Experimental Medicine, Tor Vergata University, Rome, Italy.

Ambulatory oxygen therapy (AOT) is commonly prescribed in interstitial lung disease (ILD) patients, with the aim of reducing dyspnea and increasing exercise tolerance. Despite its frequent use and a reasonable physiological rationale, there is a lack of evidence supporting the effect of AOT on improving dyspnea during exercise. Moreover, dyspnea encompasses distinct sensory (intensity, quality) and affective (anxiety, fear) components with different underlying neurophysiological mechanisms. The aim of this study was to evaluate the effect of oxygen supplementation on exercise tolerance and dyspnea in ILD patients with exercise induced hypoxia (EIH). Forty-seven ILD patients performed a six-minute walk test (6MWT) on room air (RA) and with oxygen supplementation (Ox). The 6MWT distance (6MWD) was significantly greater with oxygen supplementation (RA: 242±143 m vs Ox: 345±106 m p<0,01). With oxygen supplementation, the overall dyspnea and anxiety significantly decreased both at rest [1.1±1.4 Borg Unit (BU)] vs 0.4±0.9BU, p.<0.01, and 1.1±1.6BU vs 0.5±1.3 BU, p.<0.05, respectively) and at the end of exercise (5.1±2.6 BU vs 3.7±2.5 BU, p<0.001 and 3.4 ±2.9 vs 2.5±2.8, p.<0.01, respectively) despite a greater walked distance. In ILD patients with EIH, oxygen supplementation increases the exercise tolerance and reduces overall dyspnea perception and the anxiety component of breathlessness.

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How to Cite

Ora, Josuel, Angelo Coppola, Andrea Perduno, Gian Marco Manzetti, Ermanno Puxeddu, and Paola Rogliani. 2021. “Acute Effect of Oxygen Therapy on Exercise Tolerance and Dyspnea Perception in ILD Patients”. Monaldi Archives for Chest Disease 92 (2). https://doi.org/10.4081/monaldi.2021.1925.
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