https://doi.org/10.4081/monaldi.2021.2046
Pulmonary tuberculosis and COVID-19 coinfection: A new medical challenge
Submitted: August 7, 2021
Accepted: October 8, 2021
Published: December 3, 2021
Accepted: October 8, 2021
Abstract Views: 1626
PDF: 655
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Radiological findings in chest radiography and respiratory symptomatology represent a great challenge of interpretation during the COVID-19 (Coronavirus Disease 2019) pandemic, as their patterns can generate uncertainty at the time of diagnosis. This case highlights the importance in achieving an adequate correlation between diagnostic imaging and the clinical picture. We present a male adult who was admitted for 8 days of respiratory symptoms. Management with steroids was initiated according to the RECOVERY (Randomized Evaluation of COVID-19 Therapy) protocol and later confirmation of SARS-CoV-2 infection was received. In the following weeks, he deteriorated slowly and progressively clinically, without reaching respiratory failure. Imaging showed a thick-walled cavitation in the right lower lobe. Tuberculosis was suspected and confirmed. The uniqueness of this case of COVID-19 coinfection in a patient with undiagnosed tuberculosis, represents a diagnostic and clinical management challenge, where the proper interpretation of chest radiology is a fundamental tool.
Shereen MA, Khan S, Kazmi A, et al. COVID-19 infection: Emergence, transmission, and characteristics of human coronaviruses. J Adv Res 2020;24:91-98.
DOI: https://doi.org/10.1016/j.jare.2020.03.005
Umakanthan S, Sahu P, Ranade AV, et al. Origin, transmission, diagnosis and management of coronavirus disease 2019 (COVID-19). Postgrad M J 2020;96:753.
World Health Organization. Global tuberculosis report 2020. Last access 15 December 2020 Available from: https://www.who.int/teams/global-tuberculosis-programme/tb-reports/global-tuberculosis-report-2020
Wei M, Zhao Y, QianZ, et al. Pneumonia caused by mycobacterium tuberculosis. Microbes infect 2020;22:278-84.
DOI: https://doi.org/10.1016/j.micinf.2020.05.020
Ufimtseva E, Eremeeva N, Vakhrusheva D, Skornyakov S. Mycobacterium tuberculosis shape and size variations in alveolar macrophages of tuberculosis patients. Eur Respir J 2019;54:PA4605.
DOI: https://doi.org/10.1183/13993003.congress-2019.PA4605
Churchyard G, Kim P, Shah NS, et al. What we know about tuberculosis transmission: An overview. J Infect Dis 2017;216:S629–35.
DOI: https://doi.org/10.1093/infdis/jix362
Migliori GB, Thong PM, Alffenaar J-W, et al. Gauging the impact of the COVID-19 pandemic on tuberculosis services: a global study. Eur Respir J 2021;58:2101786.
DOI: https://doi.org/10.1183/13993003.01786-2021
Vanzetti CP, Salvo CP, Kuschner P, Brusca S. [Coinfección tuberculosis y COVID-19].[Article in Spanish]. Medicina (B. Aires) 2020;80:s100-3.
Pai M, Behr MA, Dowdy D, et al. Tuberculosis. Nat Rev Dis Primers 2016;2:16076.
DOI: https://doi.org/10.1038/nrdp.2016.76
Osuchowski MF, Winkler MS, Skirecki T, et al. The COVID-19 puzzle: deciphering pathophysiology and phenotypes of a new disease entity. Lancet Respir Med 2021;9:622–42.
DOI: https://doi.org/10.1016/S2213-2600(21)00218-6
Mousquer GT, Peres A, Fiegenbaum M. Pathology of TB/COVID-19 Co-Infection: The phantom menace. Tuberculosis 2021;126:102020.
DOI: https://doi.org/10.1016/j.tube.2020.102020
Petrone L, Petruccioli E, Vanini V, et al. Coinfection of tuberculosis and COVID-19 limits the ability to in vitro respond to SARS-CoV-2. Int J Infect Dis 2021;S1201-9712(21)00176-4. Online ahead of print.
DOI: https://doi.org/10.1016/j.ijid.2021.02.090
Udwadia ZF, Vora A, Tripathi AR, et al. COVID-19-Tuberculosis interactions: When dark forces collide. Indian J Tuberc 2020;67:S155–62.
DOI: https://doi.org/10.1016/j.ijtb.2020.07.003
Nachiappan AC, Rahbar K, Shi X, et al. Pulmonary tuberculosis: Role of radiology in diagnosis and management. Radiographics 2017;37:52–72.
DOI: https://doi.org/10.1148/rg.2017160032
Kwee TC, Kwee RM. Chest CT in covid-19: What the radiologist needs to know. Radiographics 2020;40:1848–65.
DOI: https://doi.org/10.1148/rg.2020200159
Tadolini M, Codecasa LR, García-García JM, et al. Active tuberculosis, sequelae and COVID-19 co-infection: First cohort of 49 cases. Eur Respir J 2020;56:2001398.
DOI: https://doi.org/10.1183/13993003.01398-2020
RECOVERY Collaborative Group, Horby P, Lim WS, et al. Dexamethasone in Hospitalized Patients with Covid-19. N Engl J Med 2021;384:693-704.
DOI: https://doi.org/10.1056/NEJMoa2021436
Gopalaswamy R, Subbian S. Corticosteroids for covid-19 therapy: Potential implications on tuberculosis. Int J Mol Sci 2021;22:3773.
DOI: https://doi.org/10.3390/ijms22073773
Motta I, Centis R, D’Ambrosio L, et al. Tuberculosis, COVID-19 and migrants: Preliminary analysis of deaths occurring in 69 patients from two cohorts. Pulmonology 2020;26:233-40.
DOI: https://doi.org/10.1016/j.pulmoe.2020.05.002
How to Cite
Osejo-Betancourt, Miguel, Sebastian Molina-Paez, and Mariana Rubio-Romero. 2021. “Pulmonary Tuberculosis and COVID-19 Coinfection: A New Medical Challenge”. Monaldi Archives for Chest Disease 92 (3). https://doi.org/10.4081/monaldi.2021.2046.
Copyright (c) 2021 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Varvara Solodovnikova, Ajay M.V. Kumar, Hennadz Hurevich, Yuliia Sereda, Vera Auchynka, Dzmitry Katovich, Dzmitry Klimuk, Aliaksandr Skrahin, Svetlana Setkina, Iryna Charnysh, Askar Yedilbayev, Alena Skrahina, Effectiveness and safety of delamanid- or bedaquiline-containing regimens among children and adolescents with multidrug resistant or extensively drug resistant tuberculosis: A nationwide study from Belarus, 2015-19 , Monaldi Archives for Chest Disease: Vol. 91 No. 1 (2021)
- Teona Avaliani, Yuliia Sereda, Hayk Davtyan, Nestani Tukvadze, Tamar Togonidze, Nana Kiria, Olga Denisiuk, Ogtay Gozalov, Sevim Ahmedov, Arax Hovhannesyan, Effectiveness and safety of fully oral modified shorter treatment regimen for multidrug-resistant tuberculosis in Georgia, 2019-2020 , Monaldi Archives for Chest Disease: Vol. 91 No. 1 (2021)
- M. Bugiani, S. Bonora, A. Carosso, P. Piccioni, M. Cavallero, A. Mondo, V. Ghisetti, The effect of antituberculosis treatment on interferon-γ release assay results , Monaldi Archives for Chest Disease: Vol. 75 No. 4 (2011): Pulmonary series
- D.S.C. Hui, An overview on Severe Acute Respiratory Syndrome (SARS) , Monaldi Archives for Chest Disease: Vol. 63 No. 3 (2005): Pulmonary series
- Rupak Singla, Amitesh Gupta, Vikas Kumar, Chandrasekaran Padmapriyadarsini, Devika Tayal, Shweta Anand, Abhishek Faye, AK Hemanth Kumar, Madhumita Paul Choudhary, Study of risk factors and clinical management of patients with clinical non-response due to low plasma levels of anti-tubercular drugs , Monaldi Archives for Chest Disease: Early Access
- Vinay V, Saraansh Bansal, Pallavi Purwar, Ravindra Kumar Dewan, Paras Verma, Shalini Mullick, Mallika Dixit, B Rama Phanindra , Kanishk Siddhartha, Thoracic follicular dendritic cell sarcoma - an outlandish presentation of a rare tumour with review of literature , Monaldi Archives for Chest Disease: Vol. 93 No. 2 (2023)
- S. Contini, G. Raimondi, P. Graziano, C. Saltini, M. Bocchino, Difficult diagnosis of Infliximab-related miliary tuberculosis , Monaldi Archives for Chest Disease: Vol. 61 No. 2 (2004): Pulmonary series
- D. Lykouras, F. Sampsonas, A. Kaparianos, K. Karkoulias, G. Tsoukalas, K. Spiropoulos, Human genes in TB infection: their role in immune response , Monaldi Archives for Chest Disease: Vol. 69 No. 1 (2008): Pulmonary series
- F. Scafa, C.M. Minelli, R. Fonte, G.L. Rosso, M.I. Cappelli, S.M. Candura, Silicotuberculosis in the elderly: report of two cases , Monaldi Archives for Chest Disease: Vol. 61 No. 4 (2004): Pulmonary series
- Taymmia Ejaz, Mahmood Iqbal Malik, Jamal Ahmed, Rizwan Azam, Yousaf Jamal, Sheema Saadia, Clinico-radiological and bronchoscopic predictors of microbiological yield in sputum negative tuberculosis in Pakistan , Monaldi Archives for Chest Disease: Vol. 92 No. 3 (2022)
<< < 1 2 3 4 5 6 7 8 9 10 > >>
You may also start an advanced similarity search for this article.
