https://doi.org/10.4081/monaldi.2021.2050
Association between neutrophil to lymphocyte ratio and mortality among community acquired pneumonia patients: a meta-analysis
Submitted: August 13, 2021
Accepted: November 16, 2021
Published: December 13, 2021
Accepted: November 16, 2021
Abstract Views: 2789
PDF: 1223
Supplementary 1: 117
Supplementary 2: 97
Data Analysis: 170
Supplementary 1: 117
Supplementary 2: 97
Data Analysis: 170
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The neutrophil to lymphocyte ratio (NLR) is an emerging biomarker used in the prognosis of many conditions. We aimed to conduct a meta-analysis to assess the prognostic accuracy of the NLR in determining mortality in patients with community acquired pneumonia (CAP). The PubMed, EBSCO, and Scopus databases were searched to find all relevant articles; 10 articles with 5220 patients were included. The pooled area under the curve (AUC) of NLR admission levels to predict 30-Day mortality of CAP patients was 0.706; 95% CI (0.631 to 0.781), while the pooled AUC of NLR levels taken at 3-5 days was 0.882; 95% CI (0.818 to 0.945). Meta analysis also showed a significant difference in the NLR between the survivors and 30-day non-survivors. This difference was greater when NLR levels were taken at 3-5 days; standardized mean difference (SMD) = 1.646; 95% CI (0.451 to 2.840) compared to NLR levels at admission SMD = 1.139; 95% CI (0.514 to 1.764). These results show that the NLR has potential to be incorporated in the routine assessment and stratification of CAP patients, especially in the early-stage evolution (3-5 days), keeping in mind the availability and cost effectiveness of this test.
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How to Cite
Alzoubi, Osama, and Asim Khanfar. 2021. “Association Between Neutrophil to Lymphocyte Ratio and Mortality Among Community Acquired Pneumonia Patients: A Meta-Analysis”. Monaldi Archives for Chest Disease 92 (3). https://doi.org/10.4081/monaldi.2021.2050.
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