https://doi.org/10.4081/monaldi.2022.2054
Usefulness of CURB-65, pneumonia severity index and MuLBSTA in predicting COVID-19 mortality
Accepted: February 14, 2022
Supplementary: 203
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The aim of our study is to evaluate the accuracy of CURB-65 and Pneumonia Severity Index (PSI), the most widely used scores for community acquired pneumonia, and MuLBSTA, a viral pneumonia score, in predicting 28-day mortality in Coronavirus Disease 2019 (COVID-19) pneumonia.We retrospectively collected clinical data of consecutive patients with laboratory-confirmed COVID-19 pneumonia admitted at Papa Giovanni XXIII Hospital from February 23rd to March 14th, 2020. We calculated at Emergency Department (ED) presentation CURB-65, PSI and MuLBSTA and we compared their performances in discriminating between survivors and non-survivors at 28 days. Among 431 hospitalized patients, the majority presented with hypoxic respiratory failure: median (interquartile range, IQR) PaO2/FiO2 ratio at admission was 228.6 (142.0-278.1). In the first 24 hours, 111 (27%) patients were administered low-flow oxygen cannula, 50 (12%) Venturi Mask, 95 (23%) non-rebreather mask, 106 (26%) non-invasive ventilation, 12 (3%) mechanical ventilation and 41 (9%) were not administered oxygen therapy. Mortality rate at 28-day was 35% (150/431). Between survivors and non-survivors, median (IQR) scores were, respectively, 1.0 (1.0-2.0) and 2.0 (2.0-3.0) for CURB-65 (p<0.001); 90.5 (76.0-105.5) and 115.0 (100.0-129.0) for PSI (p<0.001); 7.0 (5.0-10.0) and 11.0 (9.0-13.0) for MuLBSTA (p<0.001). Areas under the receiver operating characteristic curve (AUCs) for each score were, respectively, 0.725 (0.662-0.787), 0.776 (0.693-0.859) and 0.743 (0.680-0.806) (p>0,05). PSI and MuLBSTA did not show a better performance when compared to CURB-65. Although CURB-65, PSI and MuLBSTA scores are useful tools to discriminate between survivors and non-survivors in COVID-19 pneumonia, their diagnostic accuracy in discriminating 28-day mortality in COVID-19 pneumonia is moderate, as confirmed by AUCs <0.80, and there is a potential underestimation of disease severity in the low-risk classes. For this reason, they should not be recommended in ED to decide between inpatient and outpatient management in patients affected by COVID-19 pneumonia.
How to Cite
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Vinay V, Saraansh Bansal, Pallavi Purwar, Ravindra Kumar Dewan, Paras Verma, Shalini Mullick, Mallika Dixit, B Rama Phanindra , Kanishk Siddhartha, Thoracic follicular dendritic cell sarcoma - an outlandish presentation of a rare tumour with review of literature , Monaldi Archives for Chest Disease: Vol. 93 No. 2 (2023)
- Roberto F.E. Pedretti, Beta-blockers after myocardial infarction: Are they useful to all patients? And how long should be the beta-blocker therapy? , Monaldi Archives for Chest Disease: Vol. 88 No. 2 (2018)
- D.P. Tashkin, Smoked Marijuana as a Cause of Lung Injury , Monaldi Archives for Chest Disease: Vol. 63 No. 2 (2005): Pulmonary series
- Ankita Mandal, Ajay Kumar Verma, Sujit Kumar Kar, Jyoti Bajpai, Surya Kant, Santosh Kumar, Ram Avadh Singh Kushwaha, Rajiv Garg, Anand Srivastava, Darshan Kumar Bajaj, Sanjeev Kumar Verma, Shyam Chand Chaudhary, A cross-sectional study to determine the psychological distress among pulmonary tuberculosis patients during COVID-19 pandemic , Monaldi Archives for Chest Disease: Vol. 93 No. 1 (2023)
- Debapriya Maji, Upasna Agarwal, Lokender Kumar, Vinay V, Amit Sharma, Clinicodemographic profile and outcome of tuberculosis treatment in TB-HIV co-infected patients receiving daily ATT under a single window TB-HIV services delivery initiative , Monaldi Archives for Chest Disease: Vol. 93 No. 3 (2023)
- Nicolò Montali, Marco Bobbio, Enrico Cerrato, Giuseppe Azzaro, Bianca Bianchini, Alessandro Bonzano, Maria Vincenza Calì, Rodolfo Cavaliere, Livio Correndo, Antonella Deorsola, Regine Guillevin, Loredana Mainardi, Laura Montagna, Massimo Pistono, Gian Paolo Trevi, Management of heart failure in Piedmont Region , Monaldi Archives for Chest Disease: Vol. 70 No. 4 (2008): Cardiac series
- Richa Tyagi, Surya Kant, Sanjeev Kumar Verma, Ram Awadh Singh Kushwaha, Santosh Kumar, Rajiv Garg, Ajay Kumar Verma, Anand Srivastava, Darshan Kumar Bajaj, Anupam Wakhlu, Anit Parihar, Akshyaya Pradhan, Riddhi Jaiswal, Spectrum of interstitial lung diseases and their association with pulmonary hypertension , Monaldi Archives for Chest Disease: Vol. 92 No. 3 (2022)
- Andro Pramana Witarto, Alfian Nur Rosyid, Bendix Samarta Witarto, Shidi Laras Pramudito, Achmad Januar Er Putra, An in-depth investigation of serum Krebs von den Lungen-6 and other biomarkers in COVID-19 severity and mortality , Monaldi Archives for Chest Disease: Early Access
- Salvatore Andrea Sciurello, Francesca Graziano, Maria Marcella Laganà, Elena Compalati, Gabriele Pappacoda, Simone Gambazza, Jorge Navarro, Pietro Cecconi, Francesca Baglio, Paolo Banfi, Feasibility of high-frequency percussions in people with severe acquired brain injury and tracheostomy: an observational study , Monaldi Archives for Chest Disease: Early Access
- Vasileios Karamouzos, Fotini Fligou, Charalambos Gogos, Dimitrios Velissaris, High flow nasal cannula oxygen therapy in adults with COVID-19 respiratory failure. A case report , Monaldi Archives for Chest Disease: Vol. 90 No. 2 (2020)
<< < 8 9 10 11 12 13 14 15 16 17 > >>
You may also start an advanced similarity search for this article.
