https://doi.org/10.4081/monaldi.2022.2179
Alpha1-antitrypsin deficiency and asthma
Submitted: December 17, 2021
Accepted: February 16, 2022
Published: February 22, 2022
Accepted: February 16, 2022
Abstract Views: 2255
PDF: 762
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
α1-antitrypsin deficiency (AATD) is a genetically inherited autosomal-codominant disease with a variable clinical spectrum of lung-related diseases. Pulmonary involvement of α1-antitrypsin deficiency may also include emphysema with variable functional and radiological abnormalities, asthma, and bronchiectasis. Asthma and AATD are mutually exclusive disease entities, but the commonality of neutrophil inflammation across the diseases might suggest common underlying mechanisms of effect. The diseases share many clinical and functional features: patients with AATD commonly first present with asthma-like symptoms; functional alterations may be common to both, such as bronchial hyperresponsiveness or fixed obstruction after bronchial remodeling. It has been recognized that allergy and asthma often coexist with AATD, but the relationship between allergy, asthma and AATD is not clear. Distinguishing AATD from asthma based on presentation and clinical evaluation is not possible. The clinician must assess each of the elements in the context of the whole patient, any patient with difficult-to-manage asthma should be screened for AATD. From the clinician’s point of view, improving diagnosis in this population is fundamental to optimize clinical management. Genetic studies will probably be needed in the future to unequivocally establish the causal link between AATD and asthma.
- Cosio MG, Bazzan E, Rigobello C, Tinè M, Turato G, Baraldo S, et al. Alpha-1 antitrypsin deficiency: beyond the protease/antiprotease paradigm. Ann Am Thorac Soc. 2016;13(Suppl 4):S305–10.
- McCarthy C, Reeves EP, McElvaney NG. The role of neutrophils in alpha-1 antitrypsin deficiency. Ann Am Thorac Soc. 2016;13(Suppl 4):S297–304.
DOI: https://doi.org/10.1513/AnnalsATS.201509-634KV
- Blanco I, de Serres FJ, Fernandez-Bustillo E, Lara B, Miravitlles M. Estimated numbers and prevalence of PI*S and PI*Z alleles of alpha1-antitrypsin deficiency in European countries. Eur Respir J. 2006 Jan;27(1):77-84. doi: 10.1183/09031936.06.00062305. PMID: 16387939.
DOI: https://doi.org/10.1183/09031936.06.00062305
- de Serres FJ, Blanco I. Prevalence of α1-antitrypsin deficiency alleles PI*S and PI*Z worldwide and effective screening for each of the five phenotypic classes PI*MS, PI*MZ, PI*SS, PI*SZ, and PI*ZZ: a comprehensive review. Ther Adv Respir Dis. 2012 Oct;6(5):277-95. doi: 10.1177/1753465812457113. Epub 2012 Aug 29. PMID: 22933512.
DOI: https://doi.org/10.1177/1753465812457113
- Stockley RA, Dirksen A, Stolk J. Alpha-1 antitrypsin deficiency: the European experience. COPD. 2013 Mar;10 Suppl 1:50-3. doi: 10.3109/15412555.2013.765838. PMID: 23527820.
DOI: https://doi.org/10.3109/15412555.2013.765838
- Stoller JK, Aboussouan LS. A review of α1-antitrypsin deficiency. Am J Respir Crit Care Med. 2012 Feb 1;185(3):246-59. doi: 10.1164/rccm.201108-1428CI. Epub 2011 Sep 29. PMID: 21960536.
- Miravitlles M, Dirksen A, Ferrarotti I, Koblizek V, Lange P, Mahadeva R, McElvaney NG, Parr D, Piitulainen E, Roche N, Stolk J, Thabut G, Turner A, Vogelmeier C, Stockley RA. European Respiratory Society statement: diagnosis and treatment of pulmonary disease in α1-antitrypsin deficiency. Eur Respir J. 2017 Nov 30;50(5):1700610. doi: 10.1183/13993003.00610-2017. PMID: 29191952.
DOI: https://doi.org/10.1183/13993003.00610-2017
- Piras B, Ferrarotti I, Lara B, Martinez MT, Bustamante A, Ottaviani S, Pirina P, Luisetti M, Miravitlles M. Clinical phenotypes of Italian and Spanish patients with α1-antitrypsin deficiency. Eur Respir J. 2013 Jul;42(1):54-64. doi: 10.1183/09031936.00104712. Epub 2012 Dec 6. PMID: 23222880.
DOI: https://doi.org/10.1183/09031936.00104712
- Dickens JA, Lomas DA. Why has it been so difficult to prove the efficacy of alpha-1-antitrypsin replacement therapy? Insights from the study of disease pathogenesis. Drug Des Devel Ther. 2011;5:391-405. doi: 10.2147/DDDT.S14018. Epub 2011 Aug 17. PMID: 21966212; PMCID: PMC3180514.
DOI: https://doi.org/10.2147/DDDT.S14018
- Siri D, Farah H, Hogarth DK. Distinguishing alpha1-antitrypsin deficiency from asthma. Ann Allergy Asthma Immunol. 2013 Dec;111(6):458-64. doi: 10.1016/j.anai.2013.09.019. Epub 2013 Oct 23. PMID: 24267358.
DOI: https://doi.org/10.1016/j.anai.2013.09.019
- Demeo DL, Sandhaus RA, Barker AF, Brantly ML, Eden E, McElvaney NG, Rennard S, Burchard E, Stocks JM, Stoller JK, Strange C, Turino GM, Campbell EJ, Silverman EK. Determinants of airflow obstruction in severe alpha-1-antitrypsin deficiency. Thorax. 2007 Sep;62(9):806-13. doi: 10.1136/thx.2006.075846. Epub 2007 Mar 27. PMID: 17389752; PMCID: PMC2117297.
- Larsson C. Natural history and life expectancy in severe alpha1-antitrypsin deficiency, Pi Z. Acta Med Scand. 1978;204(5):345-51. doi: 10.1111/j.0954-6820.1978.tb08452.x. PMID: 309708.
DOI: https://doi.org/10.1111/j.0954-6820.1978.tb08452.x
- https://goldcopd.org/wp-content/uploads/2020/12/GOLD-2021-POCKET-GUIDE-v2.0-14Dec20_WMV.pdf
DOI: https://doi.org/10.54476/iimrj361
- Alpha 1-antitrypsin deficiency: memorandum from a WHO meeting. Bull World Health Organ. 1997;75(5):397-415. PMID: 9447774; PMCID: PMC2487011.
- American Thoracic Society; European Respiratory Society. American Thoracic Society/European Respiratory Society statement: standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency. Am J Respir Crit Care Med. 2003 Oct 1;168(7):818-900. doi: 10.1164/rccm.168.7.818. PMID: 14522813.
DOI: https://doi.org/10.1164/rccm.168.7.818
- Veith M, Tüffers J, Peychev E, Klemmer A, Kotke V, Janciauskiene S, Wilhelm S, Bals R, Koczulla AR, Vogelmeier CF, Greulich T. The Distribution of Alpha-1 Antitrypsin Genotypes Between Patients with COPD/Emphysema, Asthma and Bronchiectasis. Int J Chron Obstruct Pulmon Dis. 2020 Nov 6;15:2827-2836. doi: 10.2147/COPD.S271810. PMID: 33192056; PMCID: PMC7654539.
DOI: https://doi.org/10.2147/COPD.S271810
- Stoller JK, Aboussouan LS. A review of α1-antitrypsin deficiency. Am J Respir Crit Care Med. 2012 Feb 1;185(3):246-59. doi: 10.1164/rccm.201108-1428CI. Epub 2011 Sep 29. PMID: 21960536.
DOI: https://doi.org/10.1164/rccm.201108-1428CI
- Greene CM, Marciniak SJ, Teckman J, Ferrarotti I, Brantly ML, Lomas DA, Stoller JK, McElvaney NG. α1-Antitrypsin deficiency. Nat Rev Dis Primers. 2016 Jul 28;2:16051. doi: 10.1038/nrdp.2016.51. Erratum in: Nat Rev Dis Primers. 2018 Oct 29;4(1):40. PMID: 27465791.
- Needham M, Stockley RA. Alpha 1-antitrypsin deficiency. 3: Clinical manifestations and natural history. Thorax. 2004 May;59(5):441-5. doi: 10.1136/thx.2003.006510. PMID: 15115878; PMCID: PMC1746985.
DOI: https://doi.org/10.1136/thx.2003.006510
- Craig TJ, Henao MP. Advances in managing COPD related to α1 -antitrypsin deficiency: An under-recognized genetic disorder. Allergy. 2018 Nov;73(11):2110-2121. doi: 10.1111/all.13558. Epub 2018 Jul 26. PMID: 29984428; PMCID: PMC6282978.
DOI: https://doi.org/10.1111/all.13558
- Demeo DL, Sandhaus RA, Barker AF, Brantly ML, Eden E, McElvaney NG, Rennard S, Burchard E, Stocks JM, Stoller JK, Strange C, Turino GM, Campbell EJ, Silverman EK. Determinants of airflow obstruction in severe alpha-1-antitrypsin deficiency. Thorax. 2007 Sep;62(9):806-13. doi: 10.1136/thx.2006.075846. Epub 2007 Mar 27. PMID: 17389752; PMCID: PMC2117297.
DOI: https://doi.org/10.1136/thx.2006.075846
- Gramegna A, Aliberti S, Confalonieri M, Corsico A, Richeldi L, Vancheri C, Blasi F. Alpha-1 antitrypsin deficiency as a common treatable mechanism in chronic respiratory disorders and for conditions different from pulmonary emphysema? A commentary on the new European Respiratory Society statement. Multidiscip Respir Med. 2018 Oct 8;13:39. doi: 10.1186/s40248-018-0153-4. PMID: 30338069; PMCID: PMC6174569.
DOI: https://doi.org/10.4081/mrm.2018.200
- Makino S, Chosy L, Valdivia E, Reed CE. Emphysema with hereditary alpha-1 antitrypsin deficiency masquerading as asthma. J Allergy. 1970 Jul;46(1):40-8. doi: 10.1016/0021-8707(70)90060-2. PMID: 4987430.
DOI: https://doi.org/10.1016/0021-8707(70)90060-2
- Black LF, Hyatt RE, Stubbs SE. Mechanism of expiratory airflow limitation in chronic obstructive pulmonary disease associated with 1 -antitrypsin deficiency. Am Rev Respir Dis. 1972 Jun;105(6):891-9. doi: 10.1164/arrd.1972.105.6.891. PMID: 5032709.
- Mazzarella G, Bianco A, Catena E, De Palma R, Abbate GF. Th1/Th2 lymphocyte polarization in asthma. Allergy. 2000;55 Suppl 61:6-9. doi: 10.1034/j.1398-9995.2000.00511.x. PMID: 10919498.
DOI: https://doi.org/10.1034/j.1398-9995.2000.00511.x
- Survival and FEV1 decline in individuals with severe deficiency of alpha1-antitrypsin. The Alpha-1-Antitrypsin Deficiency Registry Study Group. Am J Respir Crit Care Med. 1998 Jul;158(1):49-59. doi: 10.1164/ajrccm.158.1.9712017. PMID: 9655706.
DOI: https://doi.org/10.1164/ajrccm.158.1.9712017
- Eden E, Mitchell D, Mehlman B, Khouli H, Nejat M, Grieco MH, Turino GM. Atopy, asthma, and emphysema in patients with severe alpha-1-antitrypysin deficiency. Am J Respir Crit Care Med. 1997 Jul;156(1):68-74. doi: 10.1164/ajrccm.156.1.9508014. PMID: 9230728.
DOI: https://doi.org/10.1164/ajrccm.156.1.9508014
- Katz RM, Lieberman J, Siegel SC. Alpha-1 antitrypsin levels and prevalence of Pi variant phenotypes in asthmatic children. J Allergy Clin Immunol. 1976 Jan;57(1):41-5. doi: 10.1016/0091-6749(76)90077-4. PMID: 812896.
DOI: https://doi.org/10.1016/0091-6749(76)90077-4
- Hyde JS, Werner P, Kumar CM, Moore BS. Protease inhibitor variants in children and young adults with chronic asthma. Ann Allergy. 1979 Jul;43(1):8-13. PMID: 313173.
- Townley RG, Southard JG, Radford P, Hopp RJ, Bewtra AK, Ford L. Association of MS Pi phenotype with airway hyperresponsiveness. Chest. 1990 Sep;98(3):594-9. doi: 10.1378/chest.98.3.594. PMID: 2203615.
DOI: https://doi.org/10.1378/chest.98.3.594
- Gaillard MC, Kilroe-Smith TA, Nogueira C, Dunn D, Jenkins T, Fine B, Kallenbach J. Alpha-1-protease inhibitor in bronchial asthma: phenotypes and biochemical characteristics. Am Rev Respir Dis. 1992 Jun;145(6):1311-5. doi: 10.1164/ajrccm/145.6.1311. PMID: 1595996.
DOI: https://doi.org/10.1164/ajrccm/145.6.1311
- Eden E, Holbrook JT, Brantly ML, Turino GM, Wise RA. Prevalence of alpha-1 antitrypsin deficiency in poorly controlled asthma--results from the ALA-ACRC low-dose theophylline trial. J Asthma. 2007 Oct;44(8):605-8. doi: 10.1080/02770900701540028. PMID: 17943569.
DOI: https://doi.org/10.1080/02770900701540028
- Miravitlles M, Vilà S, Torrella M, Balcells E, Rodríguez-Frías F, de la Roza C, Jardí R, Vidal R. Influence of deficient alpha1-anti-trypsin phenotypes on clinical characteristics and severity of asthma in adults. Respir Med. 2002 Mar;96(3):186-92. doi: 10.1053/rmed.2001.1237. PMID: 11905553.
DOI: https://doi.org/10.1053/rmed.2001.1237
- von Ehrenstein OS, Maier EM, Weiland SK, Carr D, Hirsch T, Nicolai T, Roscher AA, von Mutius E. Alpha1 antitrypsin and the prevalence and severity of asthma. Arch Dis Child. 2004 Mar;89(3):230-1. doi: 10.1136/adc.2002.023614. PMID: 14977698; PMCID: PMC1719844.
DOI: https://doi.org/10.1136/adc.2002.023614
- Eden E. Asthma and COPD in alpha-1 antitrypsin deficiency. Evidence for the Dutch hypothesis. COPD. 2010 Oct;7(5):366-74. doi: 10.3109/15412555.2010.510159. PMID: 20854052.
DOI: https://doi.org/10.3109/15412555.2010.510159
- Eden E, Strange C, Holladay B, Xie L. Asthma and allergy in alpha-1 antitrypsin deficiency. Respir Med. 2006 Aug;100(8):1384-91. doi: 10.1016/j.rmed.2005.11.017. Epub 2006 Jan 5. PMID: 16403617.
DOI: https://doi.org/10.1016/j.rmed.2005.11.017
- McElvaney NG, Stoller JK, Buist AS, Prakash UB, Brantly ML, Schluchter MD, Crystal RD. Baseline characteristics of enrollees in the National Heart, Lung and Blood Institute Registry of alpha 1-antitrypsin deficiency. Alpha 1-Antitrypsin Deficiency Registry Study Group. Chest. 1997 Feb;111(2):394-403. doi: 10.1378/chest.111.2.394. PMID: 9041988.
DOI: https://doi.org/10.1378/chest.111.2.394
- Aiello M, Frizzelli A, Pisi R, Fantin A, Ghirardini M, Marchi L, Ferrarotti I, Bertorelli G, Percesepe A, Chetta A. Alpha-1 antitrypsin deficiency is significantly associated with atopy in asthmatic patients. J Asthma. 2020 Oct 19:1-8. doi: 10.1080/02770903.2020.1827421. Epub ahead of print. PMID: 32962473.
DOI: https://doi.org/10.1080/02770903.2020.1827421
- Cosio MG, Bazzan E, Rigobello C, Tinè M, Turato G, Baraldo S, Saetta M. Alpha-1 Antitrypsin Deficiency: Beyond the Protease/Antiprotease Paradigm. Ann Am Thorac Soc. 2016 Aug;13 Suppl 4:S305-10. doi: 10.1513/AnnalsATS.201510-671KV. PMID: 27564665.
DOI: https://doi.org/10.1513/AnnalsATS.201510-671KV
- Jasper AE, McIver WJ, Sapey E, Walton GM. Understanding the role of neutrophils in chronic inflammatory airway disease. F1000Res. 2019 Apr 26;8:F1000 Faculty Rev-557. doi: 10.12688/f1000research.18411.1. PMID: 31069060; PMCID: PMC6489989.
DOI: https://doi.org/10.12688/f1000research.18411.1
- Nakamura H, Yoshimura K, McElvaney NG, Crystal RG. Neutrophil elastase in respiratory epithelial lining fluid of individuals with cystic fibrosis induces interleukin-8 gene expression in a human bronchial epithelial cell line. J Clin Invest. 1992 May;89(5):1478-84. doi: 10.1172/JCI115738. PMID: 1569186; PMCID: PMC443018.
DOI: https://doi.org/10.1172/JCI115738
- Hubbard RC, Fells G, Gadek J, Pacholok S, Humes J, Crystal RG. Neutrophil accumulation in the lung in alpha 1-antitrypsin deficiency. Spontaneous release of leukotriene B4 by alveolar macrophages. J Clin Invest. 1991 Sep;88(3):891-7. doi: 10.1172/JCI115391. PMID: 1653278; PMCID: PMC295476.
DOI: https://doi.org/10.1172/JCI115391
- Alfawaz, B., Bergin, D., McElvaney, N.G. et al. Alpha-1 antitrypsin regulates neutrophil reactive oxygen species production via inhibition of key players of the respiratory burst oxidase system. BMC Proc 7, P7 (2013). https://doi.org/10.1186/1753-6561-7-S1-P7
DOI: https://doi.org/10.1186/1753-6561-7-S1-P7
- Janciauskiene S, Tumpara S, Wiese M, Wrenger S, Vijayan V, Gueler F, Chen R, Madyaningrana K, Mahadeva R, Welte T, Immenschuh S, Chorostowska-Wynimko J. Alpha1-antitrypsin binds hemin and prevents oxidative activation of human neutrophils: putative pathophysiological significance. J Leukoc Biol. 2017 Oct;102(4):1127-1141. doi: 10.1189/jlb.3A0317-124R. Epub 2017 Jul 17. PMID: 28716864.
DOI: https://doi.org/10.1189/jlb.3A0317-124R
- Bousquet J, Lacoste JY, Chanez P, Vic P, Godard P, Michel FB. Bronchial elastic fibers in normal subjects and asthmatic patients. Am J Respir Crit Care Med. 1996 May;153(5):1648-54. doi: 10.1164/ajrccm.153.5.8630616. PMID: 8630616.
DOI: https://doi.org/10.1164/ajrccm.153.5.8630616
- Vignola AM, Bonanno A, Mirabella A, Riccobono L, Mirabella F, Profita M, Bellia V, Bousquet J, Bonsignore G. Increased levels of elastase and alpha1-antitrypsin in sputum of asthmatic patients. Am J Respir Crit Care Med. 1998 Feb;157(2):505-11. doi: 10.1164/ajrccm.157.2.9703070. PMID: 9476865.
DOI: https://doi.org/10.1164/ajrccm.157.2.9703070
- Gharib SA, Nguyen EV, Lai Y, Plampin JD, Goodlett DR, Hallstrand TS. Induced sputum proteome in healthy subjects and asthmatic patients. J Allergy Clin Immunol. 2011 Dec;128(6):1176-1184.e6. doi: 10.1016/j.jaci.2011.07.053. Epub 2011 Sep 8. PMID: 21906793; PMCID: PMC4065239.
DOI: https://doi.org/10.1016/j.jaci.2011.07.053
- Snelgrove RJ, Patel DF, Patel T, Lloyd CM. The enigmatic role of the neutrophil in asthma: Friend, foe or indifferent? Clin Exp Allergy. 2018 Oct;48(10):1275-1285. doi: 10.1111/cea.13191. Epub 2018 Jul 11. PMID: 29900603.
DOI: https://doi.org/10.1111/cea.13191
- Ciepiela O, Ostafin M, Demkow U. Neutrophils in asthma--a review. Respir Physiol Neurobiol. 2015 Apr;209:13-6. doi: 10.1016/j.resp.2014.12.004. Epub 2014 Dec 12. PMID: 25511380.
DOI: https://doi.org/10.1016/j.resp.2014.12.004
- Qu J, Li Y, Zhong W, Gao P, Hu C. Recent developments in the role of reactive oxygen species in allergic asthma. J Thorac Dis. 2017 Jan;9(1):E32-E43. doi: 10.21037/jtd.2017.01.05. PMID: 28203435; PMCID: PMC5303105.
DOI: https://doi.org/10.21037/jtd.2017.01.05
- Wood LG, Baines KJ, Fu J, Scott HA, Gibson PG. The neutrophilic inflammatory phenotype is associated with systemic inflammation in asthma. Chest. 2012 Jul;142(1):86-93. doi: 10.1378/chest.11-1838. PMID: 22345378.
DOI: https://doi.org/10.1378/chest.11-1838
- Cazzola M, Stolz D, Rogliani P, Matera MG. α1-Antitrypsin deficiency and chronic respiratory disorders. Eur Respir Rev. 2020 Feb 12;29(155):190073. doi: 10.1183/16000617.0073-2019. PMID: 32051168.
DOI: https://doi.org/10.1183/16000617.0073-2019
- van Veen IH, ten Brinke A, van der Linden AC, Rabe KF, Bel EH. Deficient alpha-1-antitrypsin phenotypes and persistent airflow limitation in severe asthma. Respir Med. 2006 Sep;100(9):1534-9. doi: 10.1016/j.rmed.2006.01.009. Epub 2006 Feb 14. PMID: 16476537.
DOI: https://doi.org/10.1016/j.rmed.2006.01.009
- Craig TJ. Suspecting and Testing for Alpha-1 Antitrypsin Deficiency-An Allergist's and/or Immunologist's Perspective. J Allergy Clin Immunol Pract. 2015 Jul-Aug;3(4):506-11. doi: 10.1016/j.jaip.2015.04.005. Epub 2015 May 29. PMID: 26032475.
DOI: https://doi.org/10.1016/j.jaip.2015.04.005
- Eden E, Hammel J, Rouhani FN, Brantly ML, Barker AF, Buist AS, Fallat RJ, Stoller JK, Crystal RG, Turino GM. Asthma features in severe alpha1-antitrypsin deficiency: experience of the National Heart, Lung, and Blood Institute Registry. Chest. 2003 Mar;123(3):765-71. doi: 10.1378/chest.123.3.765. PMID: 12628876.
DOI: https://doi.org/10.1378/chest.123.3.765
- Dowson LJ, Guest PJ, Stockley RA. Longitudinal changes in physiological, radiological, and health status measurements in alpha (1)-antitrypsin deficiency and factors associated with decline. Am J Respir Crit Care Med. 2001 Nov 15;164(10 Pt 1):1805-9. doi: 10.1164/ajrccm.164.10.2106036. PMID: 11734427.
DOI: https://doi.org/10.1164/ajrccm.164.10.2106036
- Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CI, Meyers DA, Levitt RC. Genetic susceptibility to asthma--bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med. 1995 Oct 5;333(14):894-900. doi: 10.1056/NEJM199510053331402. PMID: 7666875.
DOI: https://doi.org/10.1056/NEJM199510053331402
- Malerba M, Radaeli A, Ceriani L, Tantucci C, Grassi V. Airway hyperresponsiveness in a large group of subjects with alpha1-antitrypsin deficiency: a cross-sectional controlled study. J Intern Med. 2003 Mar;253(3):351-8. doi: 10.1046/j.1365-2796.2003.01083.x. PMID: 12603503.
DOI: https://doi.org/10.1046/j.1365-2796.2003.01083.x
- Kelbel T, Morris D, Walker D, Henao MP, Craig T. The Allergist's Role in Detection of Severe Alpha-1 Antitrypsin Deficiency. J Allergy Clin Immunol Pract. 2017 Sep-Oct;5(5):1302-1306. doi: 10.1016/j.jaip.2017.01.008. Epub 2017 Mar 9. PMID: 28284783.
DOI: https://doi.org/10.1016/j.jaip.2017.01.008
- Suárez-Lorenzo I, de Castro FR, Cruz-Niesvaara D, Herrera-Ramos E, Rodríguez-Gallego C, Carrillo-Diaz T. Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites. Clin Transl Allergy. 2018 Nov 2;8:44. doi: 10.1186/s13601-018-0231-x. PMID: 30410723; PMCID: PMC6214172.
DOI: https://doi.org/10.1186/s13601-018-0231-x
- Rathnayake SNH, Van den Berge M, Faiz A. Genetic profiling for disease stratification in chronic obstructive pulmonary disease and asthma. Curr Opin Pulm Med. 2019 May;25(3):317-322. doi: 10.1097/MCP.0000000000000568. PMID: 30762612.
DOI: https://doi.org/10.1097/MCP.0000000000000568
- Brantly M. Efficient and accurate approaches to the laboratory diagnosis of alpha1-antitrypsin deficiency: The promise of early diagnosis and intervention. Clin Chem. 2006 Dec;52(12):2180-1. doi: 10.1373/clinchem.2006.078907. PMID: 17138849.
DOI: https://doi.org/10.1373/clinchem.2006.078907
- National Asthma Education and Prevention Program. Expert Panel Report 3 (EPR-3): Guidelines for the Diagnosis and Management of Asthma-Summary Report 2007. J Allergy Clin Immunol. 2007 Nov;120(5 Suppl):S94-138. doi: 10.1016/j.jaci.2007.09.043. Erratum in: J Allergy Clin Immunol. 2008 Jun;121(6):1330. PMID: 17983880.
DOI: https://doi.org/10.1016/j.jaci.2007.09.029
- Stolk J, Seersholm N, Kalsheker N. Alpha1-antitrypsin deficiency: current perspective on research, diagnosis, and management. Int J Chron Obstruct Pulmon Dis. 2006;1(2):151-60. doi: 10.2147/copd.2006.1.2.151. PMID: 18046892; PMCID: PMC2706616.
DOI: https://doi.org/10.2147/copd.2006.1.2.151
- Carroll TP, O'Connor CA, Floyd O, McPartlin J, Kelleher DP, O'Brien G, Dimitrov BD, Morris VB, Taggart CC, McElvaney NG. The prevalence of alpha-1 antitrypsin deficiency in Ireland. Respir Res. 2011 Jul 13;12(1):91. doi: 10.1186/1465-9921-12-91. PMID: 21752289; PMCID: PMC3155497.
DOI: https://doi.org/10.1186/1465-9921-12-91
- Rahaghi FF, Sandhaus RA, Brantly ML, Rouhani F, Campos MA, Strange C, Hogarth DK, Eden E, Stocks JM, Krowka MJ, Stoller JK. The prevalence of alpha-1 antitrypsin deficiency among patients found to have airflow obstruction. COPD. 2012 Aug;9(4):352-8. doi: 10.3109/15412555.2012.669433. Epub 2012 Apr 16. Erratum in: COPD. 2013 Aug;10(4):555. Brantly, Mark L [added]; Rouhani, Farshid [added]; Campos, Michael A [added]. PMID: 22506682.
DOI: https://doi.org/10.3109/15412555.2012.669433
- Greene CM, Marciniak SJ, Teckman J, Ferrarotti I, Brantly ML, Lomas DA, Stoller JK, McElvaney NG. α1-Antitrypsin deficiency. Nat Rev Dis Primers. 2016 Jul 28;2:16051. doi: 10.1038/nrdp.2016.51. Erratum in: Nat Rev Dis Primers. 2018 Oct 29;4(1):40. PMID: 27465791.
DOI: https://doi.org/10.1038/nrdp.2016.51
How to Cite
Stirpe, Emanuele, and Floriana Bardaro. 2022. “Alpha1-Antitrypsin Deficiency and Asthma”. Monaldi Archives for Chest Disease 92 (4). https://doi.org/10.4081/monaldi.2022.2179.
Copyright (c) 2022 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Gabriella Bettelli, Bruno Neuner, Postoperative delirium: A preventable complication in the elderly surgical patient , Monaldi Archives for Chest Disease: Vol. 87 No. 2 (2017)
- B. Chandrasoma, D. Balfe, T. Naik, A. Elsayegh, M. Lewis, Z. Mosenifar, Pulmonary function in patients with Amyotrophic Lateral Sclerosis at disease onset , Monaldi Archives for Chest Disease: Vol. 77 No. 3-4 (2012): Pulmonary series
- C. Ortolani, F. Agostinis, S. Amoroso, R. Ariano, A. Barbato, M. Bassi, G. Cadario, P. Campi, F. Cardinale, G. Ciprandi, R. D’Anneo, M. Di Gioacchino, V. Di Rienzo, A. Fiocchi, M. Galimberti, E. Galli, M. Giovannini, C. Incorvaia, S. La Grutta, C. Lombardi, F. Marcucci, G. Marseglia, M. Minelli, A. Musarra, E. Nettis, E. Novembre, G. Pajno, G. Patriarca, F. Pezzuto, P. Piras, S. Pucci, A. Romano, C. Romano, O. Quercia, G. Scala, D. Schiavino, G. Sforza, M. Tosca, S. Tripodi, F. Frati, Practice parameters for sublingual immunotherapy , Monaldi Archives for Chest Disease: Vol. 65 No. 1 (2006): Pulmonary series
- Danish Abdul Aziz, Muhammad Aqib Sajjad, Ameema Asad, Global Initiative for Asthma (GINA) guideline: achieving optimal asthma control in children aged 6-11 years , Monaldi Archives for Chest Disease: Vol. 94 No. 3 (2024)
- Lucrezia Piccioli, Michele Arcopinto, Andrea Salzano, Roberta D'Assante, Alessandra Schiavo, Francesca M. Stagnaro, Anna Lombardi, Veronica Panicara, Pietro Valente, Giuseppe Vitale, Filippo M. Sarullo, Francesco Giallauria, Alberto M. Marra, The impairment of the Growth Hormone/Insulin-like growth factor 1 (IGF-1) axis in heart failure: A possible target for future therapy , Monaldi Archives for Chest Disease: Vol. 88 No. 3 (2018)
- Yannis Dimitroglou, Ioannis Loulakas, Maria Chounti, Michail Megalakakis, Eleni Karavana, Panagiotis Hountis, Unusual symptomatic late onset presentation of aberrant right subclavian artery: report of two cases and short literature review , Monaldi Archives for Chest Disease: Vol. 87 No. 1 (2017)
- R. Agarwal, A. Khan, A.N. Aggarwal, D. Gupta, Is the SMART approach better than other treatment approaches for prevention of asthma exacerbations? A meta-analysis , Monaldi Archives for Chest Disease: Vol. 71 No. 4 (2009): Pulmonary series
- K. Ahmad Dar, M. Shahid, A. Mubeen, R. Bhargava, Z. Ahmad, I. Ahmad, N. Islam, The role of noninvasive methods in assessing airway inflammation and structural changes in asthma and COPD , Monaldi Archives for Chest Disease: Vol. 77 No. 1 (2012): Pulmonary series
- Amelia Licari, Riccardo Ciprandi, Gianluigi Marseglia, Giorgio Ciprandi, Anxiety and depression in adolescents with asthma and in their parents: a study in clinical practice , Monaldi Archives for Chest Disease: Vol. 89 No. 3 (2019)
- F.G. Salerno, M.P. Foschino Barbaro, O. Toungoussova, E. Carpagnano, P. Guido, A. Spanevello, The extracellular matrix of the lung and airway responsiveness in asthma , Monaldi Archives for Chest Disease: Vol. 71 No. 1 (2009): Pulmonary series
<< < 1 2 3 4 5 6 7 8 9 10 > >>
You may also start an advanced similarity search for this article.
