https://doi.org/10.4081/monaldi.2022.2223
Erasmus syndrome: The association of systemic sclerosis and silicosis
Submitted: February 3, 2022
Accepted: April 7, 2022
Published: April 12, 2022
Accepted: April 7, 2022
Abstract Views: 1310
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Erasmus syndrome is the association of the exposure to silica and the subsequent development of systemic sclerosis, a rare occurrence, with scarce data in medical literature, which can be attributed to little knowledge of the syndrome and underdiagnosis. It is important to recognize this association as it has a worse respiratory prognosis than the idiopathic form of systemic sclerosis and since autoimmune diseases are rarer in men, it is easy to do exposure research when they occur. We describe the case of a 59-year-old man, a bricklayer by craft since the age of 15, who presented with respiratory symptoms and skin alterations and in whom this syndrome was diagnosed during his recent admission.
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Bermúdez A, Moyano V, Albiero J, et al. [Síndrome de Erasmus].[Article in Spanish] Rev Am Med Respir 2018;18:61-4.
Abdelghani K ben, Fazaa A, Souabni L, Zakraoui L. Association of pulmonary silicosis and systemic sclerosis. BMJ Case Rep 2015;2015:bcr2013202509.
Sharma RK, Sharma AK, Sharma A. Erasmus syndrome: Association of silicosis and systemic sclerosis. Indian Dermatol Online J 2018;9:185-7.
Ballerie A, Cavalin C, Lederlin M, et al. Association of silica exposure with chest HRCT and clinical characteristics in systemic sclerosis. Semin Arthritis Rheum 2020;50:949–56.
Pollard KM. Silica, silicosis, and autoimmunity. Front Immunol 2016;7:97.
Freire M, Alonso M, Rivera A, et al. Clinical peculiarities of patients with scleroderma exposed to silica: A systematic review of the literature. Semin Arthritis Rheum 2015;45:294–300.
Pereira F, Miranda Portilho JV, Viana de Rezende Meira JP, Ribeiro de Paula CD. Erasmus syndrome presented as CREST syndrome with Scl-70 positivity: a case report. Braz J Case Rep 2021;1:90–4.
Azevedo S, Neves J, Faria D, et al. Prevalence and clinical manifestations of Erasmus syndrome in systemic sclerosis: a cross-sectional study. Acta Reumatol Port 2020;45:183–90.
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How to Cite
Osejo-Betancourt, Miguel, and Pedro Chaparro-Mutiz. 2022. “Erasmus Syndrome: The Association of Systemic Sclerosis and Silicosis”. Monaldi Archives for Chest Disease 93 (1). https://doi.org/10.4081/monaldi.2022.2223.
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