https://doi.org/10.4081/monaldi.2022.2226

Combined SCLC clinical and pathological aspects

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Vol. 93 No. 1 (2023)
Submitted: February 7, 2022
Accepted: May 31, 2022
Published: June 8, 2022
Chemotherapy, radiotherapy, combined small cell carcinoma
Abstract Views: 842
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Authors

Filiz Çimen
fhcimen@yahoo.com
https://orcid.org/0000-0002-1983-2566
Department of Pulmonary Medicine, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Health Sciences University, Ankara, Turkey.
Sevim Düzgün
Department of Pulmonary Medicine, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Health Sciences University, Ankara, Ataturk, Turkey.
Sükran Atikcan
Department of Pulmonary Medicine, Atatürk Chest Diseases and Thoracic Surgery Training and Research Hospital, Health Sciences University, Ankara, Ataturk, Turkey.

Combined small cell lung carcinoma (C-SCLC) is rare and accounts for 1-3% of all lung cancer cases. Although its incidence has increased recently, there are limited studies on it. The records of patients admitted to our hospital between January 2015 and December 2019 and diagnosed with histologically proven combined small cell were scanned retrospectively and reviewed. 31 patients were analyzed. The average follow-up time was 10 months. The radiotherapy (RT) rate, surgery rate, and large cell malignancy rate were significantly lower in the ex group than in the living group (p=0.024, p=0.023, p=0.015). The rates of extensive disease, metastasis, and thyroid transcription factor 1 (TTF1) were significantly higher in the old group than in the living group (p=0.000, p=0.000, p=0.029, respectively). In the univariate model, sequential RT, fatigue, lactate dehydrogenase (LDH), stage, metastasis, contralateral lung metastasis, chemotherapy were observed to be significantly effective in predicting survival time (p=0.000, p=0.050, p=0.011, p=0.004, p=0.004, p=0.045, p=0.009).  In the multivariate model, independent (p=0.015, p=0.022, p=0.049) efficacy of RT, stage, and chemotherapy in predicting survival was observed. C-SCLC is a specific mixed carcinoma and reports evaluating this type are still scarce. The stage of the disease, radiotherapy and chemotherapy are extremely important in predicting survival.

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How to Cite

Çimen, Filiz, Sevim Düzgün, and Sükran Atikcan. 2022. “Combined SCLC Clinical and Pathological Aspects”. Monaldi Archives for Chest Disease 93 (1). https://doi.org/10.4081/monaldi.2022.2226.
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