https://doi.org/10.4081/monaldi.2022.2343
Sarcoidosis-like reaction secondary to adalimumab treatment in a patient with axial spondyloarthritis
Submitted: June 1, 2022
Accepted: June 23, 2022
Published: July 4, 2022
Accepted: June 23, 2022
Abstract Views: 979
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Anti-TNF agents, namely adalimumab, are safe drugs that represent an important arsenal in the treatment of immune-mediated inflammatory diseases. “Paradoxical effects” have been described with their use. A sarcoidosis “like” reaction induced by these agents is rare and is characterized by a systemic granulomatous reaction indistinguishable from sarcoidosis. We present a 55-year-old male patient, with axial spondyloarthritis, treated with with adalimumab. About 17 months under this therapy, he complained of dry cough and wheezing. Chest CT showed a peri-lymphatic and pericisural micronodular pattern and hilo-mediastinal lymph nodes, suggestive of sarcoidosis. Angiotensin converting enzyme was increased. Assuming the hypothesis of a sarcoidosis-like reaction secondary to adalimumab this therapy was discontinued with progressive improvement in the patient's complaints and in the radiological changes.
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How to Cite
Gonçalves Pimenta, Diana Alexandra, Leonor Meira, Rui Rolo, and Lurdes Ferreira. 2022. “Sarcoidosis-Like Reaction Secondary to Adalimumab Treatment in a Patient With Axial Spondyloarthritis”. Monaldi Archives for Chest Disease 93 (1). https://doi.org/10.4081/monaldi.2022.2343.
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