https://doi.org/10.4081/monaldi.2022.2360

Thoracic follicular dendritic cell sarcoma - an outlandish presentation of a rare tumour with review of literature

Vol. 93 No. 2 (2023)
Submitted: June 25, 2022
Accepted: September 8, 2022
Published: September 20, 2022
follicular dendritic cell sarcoma, primary pulmonary, endobronchial spread, pneumonectomy, diagnostic dilemma
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Authors

Vinay V
docvinayv@gmail.com
https://orcid.org/0000-0003-1691-2111
Department of Tuberculosis and Respiratory Diseases, National Institute of Tuberculosis and Respiratory Diseases (NITRD), New Delhi, India.
Saraansh Bansal
https://orcid.org/0000-0003-1373-7207
Department of Thoracic Surgery, National Institute of Tuberculosis and Respiratory Diseases (NITRD), New Delhi, India.
Pallavi Purwar
https://orcid.org/0000-0002-3893-7662
Department of Thoracic Surgery, National Institute of Tuberculosis and Respiratory Diseases (NITRD), New Delhi, India.
Ravindra Kumar Dewan
https://orcid.org/0000-0002-1936-7764
Department of Thoracic Surgery, National Institute of Tuberculosis and Respiratory Diseases (NITRD), New Delhi, India.
Paras Verma
https://orcid.org/0000-0001-5426-2354
Department of Tuberculosis and Respiratory Diseases, National Institute of Tuberculosis and Respiratory Diseases (NITRD), New Delhi, India.
Shalini Mullick
https://orcid.org/0000-0002-5842-4100
Department of Pathology, National Institute of Tuberculosis and Respiratory Diseases (NITRD), New Delhi, India.
Mallika Dixit
https://orcid.org/0000-0002-5722-3120
Department of Pathology, Core Diagnostics-Gurgaon, Haryana, India.
B Rama Phanindra
https://orcid.org/0000-0002-5155-7541
Department of Thoracic Surgery, National Institute of Tuberculosis and Respiratory Diseases (NITRD), New Delhi, India.
Kanishk Siddhartha
https://orcid.org/0000-0002-0165-0836
Department of Thoracic Surgery, National Institute of Tuberculosis and Respiratory Diseases (NITRD), New Delhi, India.

Follicular dendritic cell sarcoma is a rare low grade malignant neoplasm that arises from follicular dendritic cells in lymphoid tissue germinal centres and accounts for 0.4% of all soft tissue sarcomas. It is extremely rare to have pulmonary follicular dendritic cell sarcoma with endobronchial extension and as an anterior mediastinal mass with mediastinal lymph node involvement. We present the case of a 34-year-old male non-smoker who had been experiencing chest pain for three months. A lobulated left peri-hilar mass with endobronchial spread into the left main bronchus and mediastinal lymphadenopathy was identified on a chest CT. The bronchoscope-guided cryobiopsy of the endobronchial mass was inconclusive. After a thorough multidisciplinary discussion, the patient underwent left sided pneumonectomy, mediastinal mass resection, and systematic lymph node dissection. Histologic examination using immunohistochemistry revealed follicular dendritic cell sarcoma.

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Monda L, Warnke R, Rosai J. A primary lymph node malignancy with features suggestive of dendritic reticulum cell differentiation. A report of 4 cases. Am J Pathol 1986;122:562–72.
Kranich J, Krautler NJ. How follicular dendritic cells shape the B-cell antigenome. Front Immunol 2016;7:225. DOI: https://doi.org/10.3389/fimmu.2016.00225
Facchetti F, Simbeni M, Lorenzi L. Follicular dendritic cell sarcoma. Pathologica 2021;113:316–29. DOI: https://doi.org/10.32074/1591-951X-331
Dalia S, Shao H, Sagatys E, et al. Dendritic cell and histiocytic neoplasms: Biology, diagnosis, and treatment. Cancer Control 2014;21:290–300. DOI: https://doi.org/10.1177/107327481402100405
Facchetti F, Lorenzi L. Follicular dendritic cells and related sarcoma. Semin Diagno Pathol 2016;33:262–76. DOI: https://doi.org/10.1053/j.semdp.2016.05.002
Pathology Outlines [Internet]. Follicular dendritic cell sarcoma (FDCS). Accessed: 2022 Feb 18. Available from: https://www.pathologyoutlines.com/topic/lymphnodesFDCsarcoma.html
Massoth LR, Hung YP, Ferry JA, et al. Histiocytic and dendritic cell sarcomas of hematopoietic origin share targetable genomic alterations distinct from follicular dendritic cell sarcoma. Oncologist 2021;26:e1263–72. DOI: https://doi.org/10.1002/onco.13801
Chen T, Gopal P. Follicular dendritic cell sarcoma. Arch Pathol Lab Med 2017;141:596–9. DOI: https://doi.org/10.5858/arpa.2016-0126-RS
Saygin C, Uzunaslan D, Ozguroglu M, et al. Dendritic cell sarcoma: A pooled analysis including 462 cases with presentation of our case series. Crit Rev Oncol Hematol 2013;88:253-71. DOI: https://doi.org/10.1016/j.critrevonc.2013.05.006
Gounder M, Desai V, Kuk D, et al. Impact of surgery, radiation and systemic therapy on the outcomes of patients with dendritic cell and histiocytic sarcomas. Eur J Cancer 2015;51:2413–22. DOI: https://doi.org/10.1016/j.ejca.2015.06.109

How to Cite

V, Vinay, Saraansh Bansal, Pallavi Purwar, Ravindra Kumar Dewan, Paras Verma, Shalini Mullick, Mallika Dixit, B Rama Phanindra, and Kanishk Siddhartha. 2022. “Thoracic Follicular Dendritic Cell Sarcoma - an Outlandish Presentation of a Rare Tumour With Review of Literature”. Monaldi Archives for Chest Disease 93 (2). https://doi.org/10.4081/monaldi.2022.2360.
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