https://doi.org/10.4081/monaldi.2022.2368
Interstitial nephritis secondary to treatment with pembrolizumab, a rare complication in two patients with lung adenocarcinoma
Submitted: July 5, 2022
Accepted: July 19, 2022
Published: July 28, 2022
Accepted: July 19, 2022
Abstract Views: 957
PDF: 367
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Immune checkpoint inhibitors (ICPi) have become nowadays one of the most widely prescribed anticancer treatments. Pembrolizumab is a highly selective monoclonal immunoglobulin approved as a first-line monotherapy treatment in adult patients with untreated advanced non-small cell lung cancer (NSCLC) with programmed cell death 1 (PD-L1) expression greater than 50% and lack of mutations. ICPi can precipitate immune-related adverse events. Data on the incidence and characteristics of nephrotoxicity from ICPi are limited and caused largely from small case series and oncologic studies. Two patients with a diagnosis of pulmonary adenocarcinoma, undergoing treatment with pembrolizumab who manifested interstitial nephritis secondary to this treatment, are presented below. The growing use of immunotherapy in the treatment of cancer imposes the physician's attention to possible adverse effects.
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How to Cite
Gonçalves Pimenta, Diana Alexandra, Renata Carvalho, Raquel Pereira, Rui Rolo, and Lurdes Ferreira. 2022. “Interstitial Nephritis Secondary to Treatment With Pembrolizumab, a Rare Complication in Two Patients With Lung Adenocarcinoma”. Monaldi Archives for Chest Disease 93 (2). https://doi.org/10.4081/monaldi.2022.2368.
Copyright (c) 2022 The Author(s)
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