https://doi.org/10.4081/monaldi.2022.2388
Alectinib rescue therapy in advanced ALK rearranged lung adenocarcinoma: a case report
Submitted: July 27, 2022
Accepted: September 14, 2022
Published: September 20, 2022
Accepted: September 14, 2022
Abstract Views: 1112
PDF: 218
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Alectinib is a highly selective tyrosine kinase inhibitor of anaplastic lymphoma kinase (ALK) that is approved as first-line treatment in adult patients with ALK-positive non-small cell lung cancer (NSCLC) and as second-line in patients previously treated with crizotinib, and has been shown in the literature to significantly prolong progression-free survival compared to chemotherapy in patients with advanced non-small cell lung cancer. The authors describe a clinical case of a 24-year-old woman with malignant massive pleural effusion caused by ALK rearranged pulmonary adenocarcinoma with pleural and pericardial metastasis, in which, despite a dramatic clinical debut, the correct and timely management of the diagnostic and therapeutic path allowed for extraordinary therapeutic success.
Porcel JM, Gasol A, Bielsa S, et al. Clinical features and survival of lung cancer patients with pleural effusions. Respirology 2015;20:654-9.
DOI: https://doi.org/10.1111/resp.12496
Comella P, Frasci G, De Cataldis G, et al. Cisplatin/carboplatin + etoposide + vinorelbine in advanced non-small-cell lung cancer: a multicentre randomised trial. Gruppo Oncologico Campano. Br J Cancer 1996;74:1805-11.
DOI: https://doi.org/10.1038/bjc.1996.634
Cattaneo F, Guerra G, Parisi M, et al. Expression of formyl-peptide receptors in human lung carcinoma. Anticancer Res 2015;35:2769-74.
Bianco A, Perrotta F, Barra G, et al. Prognostic factors and biomarkers of responses to immune checkpoint inhibitors in lung cancer. Int J Mol Sci 2019;20:4931.
DOI: https://doi.org/10.3390/ijms20194931
Perrotta F, Rocco D, Vitiello F, et al. Immune checkpoint blockade for advanced NSCLC: A new landscape for elderly patients. Int J Mol Sci 2019;20:2258.
DOI: https://doi.org/10.3390/ijms20092258
Cameron LB, Hitchen N, Chandran E, et al. Targeted therapy for advanced anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer. Cochrane Database Syst Rev 2022;1:CD013453.
DOI: https://doi.org/10.1002/14651858.CD013453.pub2
Golding B, Luu A, Jones R, Viloria-Petit AM. The function and therapeutic targeting of anaplastic lymphoma kinase (ALK) in non-small cell lung cancer (NSCLC). Mol Cancer 2018;17:52.
DOI: https://doi.org/10.1186/s12943-018-0810-4
Moore DA, Benafif S, Poskitt B, et al. Optimising fusion detection through sequential DNA and RNA molecular profiling of non-small cell lung cancer. Lung Cancer 2021;161:55-9.
DOI: https://doi.org/10.1016/j.lungcan.2021.08.008
Doxtader EE, Cheng YW, Zhang Y. Molecular testing of non-small cell lung carcinoma diagnosed by endobronchial ultrasound-guided transbronchial fine-needle aspiration: The Cleveland clinic experience. Arch Pathol Lab Med 2019;143:670-6.
DOI: https://doi.org/10.5858/arpa.2017-0184-RA
Perrotta F, Nankivell M, Adizie JB, et al. Endobronchial ultrasound-guided transbronchial needle aspiration for PD-L1 testing in non-small cell lung cancer. Chest 2020;158:1230-9.
DOI: https://doi.org/10.1016/j.chest.2020.04.059
Ando K, Akimoto K, Sato H, et al. Brigatinib and alectinib for ALK rearrangement-positive advanced non-small cell lung cancer with or without central nervous system metastasis: A systematic review and network meta-analysis. Cancers (Basel) 2020;12:942.
DOI: https://doi.org/10.3390/cancers12040942
Serritella AV, Bestvina CM. Anaplastic lymphoma kinase mutation-positive non-small cell lung cancer. Thorac Surg Clin 2020;30:137-46.
DOI: https://doi.org/10.1016/j.thorsurg.2019.12.001
How to Cite
Cesaro, Cristiano, Umberto Caterino, Fabio Perrotta, Umberto Masi, Alessandra Cotroneo, Roberta Cianci, Enzo Zamparelli, Flavio Cesaro, Dario Amore, and Danilo Rocco. 2022. “Alectinib Rescue Therapy in Advanced ALK Rearranged Lung Adenocarcinoma: A Case Report”. Monaldi Archives for Chest Disease 93 (3). https://doi.org/10.4081/monaldi.2022.2388.
Copyright (c) 2022 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Ekta Gupta, Pooja Singh, Sunaina Tejpal Karna, Yogesh Niwariya, Vaishali Waindeskar, Sourabh Jain, Rajesh Panda, Sandeep Kumar, Comparison of lung ultrasound technique versus clinical method to evaluate the accuracy of size and placement of left endobronchial double lumen tube in patients undergoing elective thoracic surgery: a prospective observational study , Monaldi Archives for Chest Disease: Early Access
- J.K. Stoller, On the Evidence that Augmentation Therapy Helps Asthma: Are Storks Really Responsible for New Babies? , Monaldi Archives for Chest Disease: Vol. 69 No. 4 (2008): Pulmonary series
- Elena Bargagli, Viola Bonti, Alessandra Bindi, Vieri Scotti, Massimo Pistolesi, Luca Voltolini, Katia Ferrari, Fibrotic lung toxicity induced by cytotoxic drugs, radiation and immunotherapy in patients treated for lung cancer , Monaldi Archives for Chest Disease: Vol. 88 No. 2 (2018)
- Laura Casaretti, Stefania Paolillo, Roberto Formisano, Ada Bologna, Giacomo Mattiello, Sirio Conte, Laura Petraglia, Francesco Lo Iudice, Irma Fabiani, Anna Paola Cirillo, Alice Vitagliano, Francesco Gambardella, Giuseppe Luca della Ratta, Pasquale Perrone Filardi, Metabolic and cardiovascular effects of combined antiretroviral therapy in patients with HIV infection. Systematic review of literature , Monaldi Archives for Chest Disease: Vol. 76 No. 4 (2011): Cardiac series
- Deepak Sharma, Vinay V, Jitendra Kumar Saini, Prabhpreet Sethi, Lokender Kumar, Praveen Kumar Dubey, Assessing the effectiveness and safety of transbronchial lung cryobiopsy utilizing a flexible bronchoscope with an endobronchial blocker in diffuse parenchymal lung lesions , Monaldi Archives for Chest Disease: Early Access
- William Newmarch, Angelica Puopolo, Madina Weiler, Brian Casserly, Hamman-Rich syndrome: a forgotten entity , Monaldi Archives for Chest Disease: Vol. 87 No. 1 (2017)
- Syed Muhammad Zubair, Mariyam Gohar Ali, Muhammad Irfan, Post tuberculosis radiological sequelae in patients treated for pulmonary and pleural tuberculosis at a tertiary center in Pakistan , Monaldi Archives for Chest Disease: Vol. 92 No. 1 (2022)
- Daniele Magnini, Emilio Bria, Alessandra Cancellieri, Vanina Livi, Fausto Leoncini, Marco Ferrari, Teresa Bruni, Daniela Paioli, Rocco Trisolini, Bronchoscopically-visible massive central airway cancer cavitation is associated with metastatic disease, lack of actionable mutations and poor prognosis: a case series , Monaldi Archives for Chest Disease: Early Access
- G.F. Tassi, G.P. Marchetti, P.L. Aliprandi, Advanced Medical Thoracoscopy , Monaldi Archives for Chest Disease: Vol. 75 No. 1 (2011): Pulmonary series
- Biagio Polla, Roflumilast is effective in reducing COPD related exacerbations and improving CAT score , Monaldi Archives for Chest Disease: Vol. 79 No. 3-4 (2013): Pulmonary series - Supplement 1
<< < 7 8 9 10 11 12 13 14 15 16 > >>
You may also start an advanced similarity search for this article.
