https://doi.org/10.4081/monaldi.2022.2388

Alectinib rescue therapy in advanced ALK rearranged lung adenocarcinoma: a case report

Vol. 93 No. 3 (2023)
Submitted: July 27, 2022
Accepted: September 14, 2022
Published: September 20, 2022
Lung adenocarcinoma, malignant pleural effusion, anaplastic lymphoma kinase inhibitor therapy (ALK)
Abstract Views: 1297
PDF: 236
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Authors

Cristiano Cesaro
cristianocesaro@gmail.com
https://orcid.org/0000-0002-1023-7744
Unit of Bronchology, Monaldi Hospital, A.O. Dei Colli of Naples, Italy.
Umberto Caterino
Unit of Bronchology, Monaldi Hospital, A.O. Dei Colli of Naples, Italy.
Fabio Perrotta
https://orcid.org/0000-0002-7223-7037
Unit of Pulmonology, University of Campania “L. Vanvitelli”, Monaldi Hospital, A.O. Dei Colli of Naples, Italy.
Umberto Masi
UUnit of Pulmonology, University of Campania “L. Vanvitelli”, Monaldi Hospital, A.O. Dei Colli of Naples, Italy.
Alessandra Cotroneo
Unit of Pulmonology, University of Campania “L. Vanvitelli”, Monaldi Hospital, A.O. Dei Colli of Naples, Italy.
Roberta Cianci
https://orcid.org/0000-0002-5002-0128
Unit of Pulmonology, University of Campania “L. Vanvitelli”, Monaldi Hospital, A.O. Dei Colli of Naples, Italy.
Enzo Zamparelli
Unit of Anesthesia and Resuscitation, Monaldi Hospital, A.O. Dei Colli of Naples , Italy.
Flavio Cesaro
Unit of Emergency Medicine and Surgery and First Aid, C.T.O. Hospital, Naples, Italy.
Dario Amore
Unit of Thoracic Surgery Monaldi Hospital, A.O. Dei Colli of Naples, Italy.
Danilo Rocco
Unit of Oncological Pulmonology, Monaldi Hospital, A.O. Dei Colli of Naples, Italy.

Alectinib is a highly selective tyrosine kinase inhibitor of anaplastic lymphoma kinase (ALK) that is approved as first-line treatment in adult patients with ALK-positive non-small cell lung cancer (NSCLC) and as second-line in patients previously treated with crizotinib, and has been shown in the literature to significantly prolong progression-free survival compared to chemotherapy in patients with advanced non-small cell lung cancer. The authors describe a clinical case of a 24-year-old woman with malignant massive pleural effusion caused by ALK rearranged pulmonary adenocarcinoma with pleural and pericardial metastasis, in which, despite a dramatic clinical debut, the correct and timely management of the diagnostic and therapeutic path allowed for extraordinary therapeutic success.

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How to Cite

Cesaro, Cristiano, Umberto Caterino, Fabio Perrotta, Umberto Masi, Alessandra Cotroneo, Roberta Cianci, Enzo Zamparelli, Flavio Cesaro, Dario Amore, and Danilo Rocco. 2022. “Alectinib Rescue Therapy in Advanced ALK Rearranged Lung Adenocarcinoma: A Case Report”. Monaldi Archives for Chest Disease 93 (3). https://doi.org/10.4081/monaldi.2022.2388.
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