https://doi.org/10.4081/monaldi.2022.2402
Red blood cell distribution width to predict mortality in heart transplant recipients: a systematic review
Submitted: August 10, 2022
Accepted: August 27, 2022
Published: September 5, 2022
Accepted: August 27, 2022
Abstract Views: 1216
PDF: 370
Supplementary: 187
Supplementary: 187
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Red blood cell distribution width (RDW) has been shown to have prognostic value in a number of different clinical settings, such as cardiovascular disease, including heart failure. However, its prognostic value in heart transplant (HT) recipients remains unknown. The aim of this systematic review is to determine the prognostic value of pre-transplant RDW for mortality in HT recipients. There is a pre-published protocol of this review. The terms "Heart transplant", "Red cell distribution width" and their synonyms were used in the search strategy. PubMed/Medline, Embase, Scopus, Web of Science and LILACS were searched until May 17th, 2022, without date or language restrictions. Two authors independently carried out the selection, first by title and abstract, second by full-text revision. Discrepancies were discussed and resolved with three other authors. Quality of individual studies was assessed with Newcastle Ottawa Scale (NOS) for cohorts. After removing the duplicates, 3885 articles were identified. Four articles were included in the qualitative synthesis. Three studies were classified as “good quality”: whereas one as “poor quality” according to NOS scale. All the included articles evaluated long-term mortality and one study also evaluated short-term mortality. In this one, a correlation between higher RDW values and short-term mortality was reported. Meanwhile, in all the studies, a high pre-HT RDW was a marker of long-term mortality following cardiac transplantation. Our review shows that an elevated on-admission RDW is associated with long-term mortality in heart transplantation recipients.
Chadi M, Eckman P. Adult heart transplant: indications and outcomes. J Thorac Dis 2014;6:1120–8.
Ahmed T, Jain A. Heart Transplantation. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing; 2021.
Lund LH, Edwards LB, Kucheryavaya AY, et al. The Registry of the International Society for Heart and Lung Transplantation: Thirtieth Official Adult Heart Transplant Report - 2013; Focus Theme: Age. J Hear Lung Transplant 2013;32:951-64.
DOI: https://doi.org/10.1016/j.healun.2013.08.006
Khush KK, Cherikh WS, Chambers DC, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth Adult Heart Transplantation Report - 2018; Focus Theme: Multiorgan Transplantation. J Hear Lung Transplant 2018;37:1155–68.
DOI: https://doi.org/10.1016/j.healun.2018.07.022
Lund LH, Edwards LB, Kucheryavaya AY, et al. The Registry of the International Society for Heart and Lung Transplantation: Thirty-first Official Adult Heart Transplant Report - 2014; Focus Theme: Retransplantation. J Hear Lung Transplant.2014;33:996-1008.
DOI: https://doi.org/10.1016/j.healun.2014.08.003
Barge-Caballero E, Segovia-Cubero J, Almenar-Bonet L, et al. Preoperative INTERMACS profiles determine postoperative outcomes in critically ill patients undergoing emergency heart transplantation. Circ Hear Fail 2013;6:763–72.
DOI: https://doi.org/10.1161/CIRCHEARTFAILURE.112.000237
Friesen EL, Foroutan F, Krakovsky J, Chih S, et al. Utility of the INTERMACS profile at the time of assessment for heart transplant. Clin Transplant 2020;34:e13796
DOI: https://doi.org/10.1111/ctr.13796
Salvagno GL, Sanchis-Gomar F, Picanza A, Lippi G. Red blood cell distribution width: A simple parameter with multiple clinical applications. Crit Rev Clin Lab Sci 2015;52:86-105.
DOI: https://doi.org/10.3109/10408363.2014.992064
Li N, Zhou H, Tang Q. Red blood cell distribution width: A novel predictive indicator for cardiovascular and cerebrovascular diseases. Dis Markers 2017;2017:1–23.
DOI: https://doi.org/10.1155/2017/7089493
Lippi G, Turcato G, Cervellin G, Sanchis-Gomar F. Red blood cell distribution width in heart failure: A narrative review. World J Cardiol 2018;10:6-14.
DOI: https://doi.org/10.4330/wjc.v10.i2.6
Huang Y-L, Hu Z-D, Liu S-J, Sun Y, et al. Prognostic value of red blood cell distribution width for patients with heart failure: A systematic review and meta-analysis of cohort studies. PLoS One 2014;9:e104861.
DOI: https://doi.org/10.1371/journal.pone.0104861
Segura-Saldaña P, Acuña-Chávez M, Cruzalegui-Bazán C, Alvarez-Vargas M. Red blood cell distribution width in heart transplant recipients. PROSPERO [Internet]. 2021; Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42021271074
Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372:n71.
DOI: https://doi.org/10.1136/bmj.n71
Wells G, Shea B, O’Connell D, Peterson J, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses [Internet]. 2000. Available from: http://www.ohri.ca/programs/clinical_epidemiology/oxford.asp
Penson D, Krishnaswami S, Jules A, Seroogy J, et al. Evaluation and treatment of cryptorchidism [Internet]. Rockville: Agency for Healthcare Research and Quality (AHRQ); 2012.
Lechiancole A, Sponga S, Vendramin I, et al. Red blood distribution width and heart transplantation. J Cardiovasc Med 2019;20:145–51.
DOI: https://doi.org/10.2459/JCM.0000000000000747
Poglajen G, Podgorsek B, Sever M, Knezevic I, et al. Pre-transplant red cell distribution width predicts short term outcome after heart transplantation. J Hear Lung Transplant 2015;34:S294.
DOI: https://doi.org/10.1016/j.healun.2015.01.826
Szygula-Jurkiewicz B, Szczurek W, Skrzypek M, et al. Red blood cell distribution width in end-stage heart failure patients is independently associated with all-cause mortality after orthotopic heart transplantation. Transplant Proc 2018;50:2095–9.
DOI: https://doi.org/10.1016/j.transproceed.2018.02.141
Truby LK, Garan AR, Givens R, et al. Red cell distribution width predicts 1-year mortality following heart transplantation. J Hear Lung Transplant 2017;36:S234.
DOI: https://doi.org/10.1016/j.healun.2017.01.619
Duchnowski P, Hryniewiecki T, Stokłosa P, Kuśmierczyk M, et al. Red cell distribution width as a prognostic marker in patients undergoing valve surgery. J Heart Valve Dis 2017;26:714–20.
DOI: https://doi.org/10.1093/eurheartj/ehx493.P5436
Mucsi I, Ujszaszi A, Czira ME, et al. Red cell distribution width is associated with mortality in kidney transplant recipients. Int Urol Nephrol 2014;46:641–51.
DOI: https://doi.org/10.1007/s11255-013-0530-z
Sotiropoulos K, Yerly P, Monney P, et al. Red cell distribution width and mortality in acute heart failure patients with preserved and reduced ejection fraction. ESC Hear Fail 2016;3:198–204.
DOI: https://doi.org/10.1002/ehf2.12091
Wang B, Aihemaiti G, Cheng B, Li X. Red blood cell distribution width is associated with all-cause mortality in critically ill patients with cardiogenic shock. Med Sci Monit 2019;25:7005–15.
DOI: https://doi.org/10.12659/MSM.917436
Hoffmann JJML, Nabbe KCAM, van den Broek NMA. Effect of age and gender on reference intervals of red blood cell distribution width (RDW) and mean red cell volume (MCV). Clin Chem Lab Med 2015;53:2015-9.
DOI: https://doi.org/10.1515/cclm-2015-0155
Lippi G, Salvagno GL, Guidi GC. Red blood cell distribution width is significantly associated with aging and gender. Clin Chem Lab Med 2014;52:e197-9.
DOI: https://doi.org/10.1515/cclm-2014-0353
Fava C, Cattazzo F, Hu Z-D, et al. The role of red blood cell distribution width (RDW) in cardiovascular risk assessment: useful or hype? Ann Transl Med 2019;7:581.
DOI: https://doi.org/10.21037/atm.2019.09.58
Seth HS, Mishra P, Khandekar JV, et al. Relationship between high red cell distribution width and systemic inflammatory response syndrome after extracorporeal circulation. Braz J Cardiov Surg 2017;32:288-94.
DOI: https://doi.org/10.21470/1678-9741-2017-0023
Farah R, Khamisy-Farah R. Significance of MPV, RDW with the presence and severity of metabolic syndrome. Exp Clin Endocrinol Diabetes 2015;123:567–70.
DOI: https://doi.org/10.1055/s-0035-1564072
Bolatov AK, Seisembekov TZ, Askarova AZ, Baikanova RK, et al. Online-learning due to COVID-19 improved mental health among medical students. Med Sci Educ 2021;31:183–92.
DOI: https://doi.org/10.1007/s40670-020-01165-y
Geiger C, Föller M, Herrlinger KR, Lang F. Azathioprine-induced suicidal erythrocyte death. Inflamm Bowel Dis 2008;14:1027–32.
DOI: https://doi.org/10.1002/ibd.20433
How to Cite
Acuña-Chávez, Luis Miguel, Claudia Cruzalegui-Bazán, Carlos Quispe-Vicuña, Clara Saldarriaga, Johanna Contreras, José A. Chávez-Peche, Mayita Alvarez-Vargas, and Pedro Segura-Saldaña. 2022. “Red Blood Cell Distribution Width to Predict Mortality in Heart Transplant Recipients: A Systematic Review”. Monaldi Archives for Chest Disease 93 (2). https://doi.org/10.4081/monaldi.2022.2402.
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