https://doi.org/10.4081/monaldi.2023.2488
When benign leiomyomas metastasize to the lungs - a case report
Submitted: November 19, 2022
Accepted: January 23, 2023
Published: February 3, 2023
Accepted: January 23, 2023
Abstract Views: 644
PDF: 136
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Benign metastasizing leiomyoma is a rare disease that primarily affects premenopausal women who have a history of uterine leiomyoma, which is characterized by pulmonary metastases. The pathogenesis of this condition is unknown. Patients are usually asymptomatic or have vague symptoms. Pathological examination in conjunction with immunohistochemistry is required for diagnosis. Treatment is determined by the patient's age, hormonal status, symptoms, and the extent of the lesions (number, size, and location of nodules), with surgical resection being the most effective. We present the case of a 72-year-old woman who had a total hysterectomy 30 years earlier due to myomas and developed a persistent dry cough. Her computed tomography of the chest revealed several small nodules in the pulmonary parenchyma. Because of the nodules' small size and difficult accessibility, a surgical biopsy was performed for histopathological examination and immunohistochemical staining, which revealed metastasizing leiomyoma. Letrozole treatment was started and was well tolerated.
Pacheco-Rodriguez G, Taveira-DaSilva AM, Moss J. Benign metastasizing leiomyoma. Clin Chest Med 2016;37:589–95.
DOI: https://doi.org/10.1016/j.ccm.2016.04.019
Fan R, Feng F, Yang H, et al. Pulmonary benign metastasizing leiomyomas: a case series of 23 patients at a single facility. BMC Pulm Med 2020;20:1–7.
DOI: https://doi.org/10.1186/s12890-020-01330-4
Barnas E, Ksiazek M, Ras R, et al. Benign metastasizing leiomyoma: A review of current literature in respect to the time and type of previous gynecological surgery. PLoS One 2017;12:e0175875.
DOI: https://doi.org/10.1371/journal.pone.0175875
Robboy SJ, Bentley RC, Butnor K, Anderson MC. Pathology and pathophysiology of uterine smooth-muscle tumors. Environ Health Perspect 2000;108:S779–84.
DOI: https://doi.org/10.1289/ehp.00108s5779
Mahmoud MS, Desai K, Nezhat FR. Leiomyomas beyond the uterus; benign metastasizing leiomyomatosis with paraaortic metastasizing endometriosis and intravenous leiomyomatosis: a case series and review of the literature. Arch Gynecol Obstet 2014;291:223–30.
DOI: https://doi.org/10.1007/s00404-014-3356-8
Kayser K, Zink S, Schneider T, et al. Benign metastasizing leiomyoma of the uterus: documentation of clinical, immunohistochemical and lectin-histochemical data of ten cases. Virchows Arch 2000;437:284–92.
DOI: https://doi.org/10.1007/s004280000207
Abramson S, Gilkeson RC, Goldstein JD, et al. Benign metastasizing leiomyoma: clinical, imaging, and pathologic correlation. AJR Am J Roentgenol 2001;176:1409-13.
DOI: https://doi.org/10.2214/ajr.176.6.1761409
Awonuga AO, Shavell VI, Imudia AN, et al. Pathogenesis of benign metastasizing leiomyoma: a review. Obstet Gynecol Surv 2010;65:189-95.
DOI: https://doi.org/10.1097/OGX.0b013e3181d60f93
Ahmad SZ, Anupama R, Vijaykumar DK. Benign metastasizing leiomyoma - case report and review of literature. Eur J Obstet Gynecol Reprod Biol 2011;159:240-1.
DOI: https://doi.org/10.1016/j.ejogrb.2011.07.017
Abu Saadeh F, Riain CO, Cormack CM, Gleeson N. Lung metastases from benign uterine leiomyoma: does 18-FDG-PET/CT have a role to play? Ir J Med Sci 2019;188:619-24.
DOI: https://doi.org/10.1007/s11845-018-1876-0
di Scioscio V di, Feraco P, Miglio L, et al. Benign metastasizing leiomyoma of the lung: PET findings. J Thorac Imaging 2009;24:41-4.
DOI: https://doi.org/10.1097/RTI.0b013e31818a0840
Chen S, Zhang Y, Zhang J, et al. Pulmonary benign metastasizing leiomyoma from uterine leiomyoma. World J Surg Oncol 2013;11:163.
DOI: https://doi.org/10.1186/1477-7819-11-163
Rivera JA, Christopoulos S, Small D, Trifiro M. Hormonal manipulation of benign metastasizing leiomyomas: report of two cases and review of the literature. J Clin Endocrinol Metab 2004;89:3183–8.
DOI: https://doi.org/10.1210/jc.2003-032021
Ottlakan A, Borda B, Lazar G, et al. Treatment decision based on the biological behavior of pulmonary benign metastasizing leiomyoma. J Thorac Dis 2016;8:E672–6.
DOI: https://doi.org/10.21037/jtd.2016.06.61
Vaquero ME, Magrina JF, Leslie KO. Uterine smooth-muscle tumors with unusual growth patterns. J Minim Invasive Gynecol 2009;16:263–8.
DOI: https://doi.org/10.1016/j.jmig.2009.01.013
How to Cite
Vieira Naia, Joana, Diana Pimenta, Anita Paiva, Rita Costa, Conceição Souto de Moura, Raquel Pereira, and João Filipe Cruz. 2023. “When Benign Leiomyomas Metastasize to the Lungs - a Case Report”. Monaldi Archives for Chest Disease 93 (4). https://doi.org/10.4081/monaldi.2023.2488.
Copyright (c) 2023 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- D. Eleftheriou, S. Katsenos, S. Zorbas, I. Griveas, K. Psathakis, Pulmonary fibrosis presenting as an early manifestation of microscopic polyangiitis , Monaldi Archives for Chest Disease: Vol. 77 No. 3-4 (2012): Pulmonary series
- Chiara Penati, Cristoforo Incorvaia, Valentina Mollo, Federica Lietti, Gemma Gatto, Marco Stefanelli, Paola Centeleghe, Giuseppe Talarico, Ileana Mori, Cristina Franzelli, Fosco Ratti, Maria Paola Ponticelli, Ermina Ridolo, Oreste Carlo Febo, Cardiac rehabilitation outcome after transcatheter aortic valve implantation , Monaldi Archives for Chest Disease: Vol. 91 No. 2 (2021)
- Emmanouil Panagiotou, Ioannis Vamvakaris, Nikolaos K. Syrigos, Elias Kotteas, Pulmonary benign metastasizing leiomyoma: a case report , Monaldi Archives for Chest Disease: Vol. 94 No. 1 (2024)
- Anna Stainer, Paola Faverio, Francesca Bono, Alberto Pesci, An unusual presentation of pulmonary lymphoma: When diffuse ground glass opacities can mean anything , Monaldi Archives for Chest Disease: Vol. 88 No. 1 (2018)
- R. Agarwal, N. Singh, A.N. Aggarwal, An unusual association between Mycobacterium tuberculosis and Aspergillus fumigatus , Monaldi Archives for Chest Disease: Vol. 69 No. 1 (2008): Pulmonary series
- H. Yuksel, O. Yilmaz, R. Savas, C. Kirmaz, A. Sogut, S. Özalp, Pulmonary hemosiderosis with normocomplementemic urticarial vasculitis in a child , Monaldi Archives for Chest Disease: Vol. 67 No. 1 (2007): Pulmonary series
- Janet Fallon, Martin Plummeridge, Richard Daly, Andrew Medford, Linear probe 19-gauge endobronchial ultrasound diagnosis of a benign chondroid hamartoma , Monaldi Archives for Chest Disease: Vol. 88 No. 1 (2018)
- Fiorella Devito, Annapaola Zito, Silvano Dragonieri, Pierluigi Carratù, Vitaliano N. Quaranta, Francesco Vitale, Nicola Quaranta, Francesco Panza, Giancarlo Logroscino, Matteo Cameli, Onofrio Resta, Marco Matteo Ciccone, Evaluation of endothelial function and cardiovascular risk in non-obese patients with slight degree of obstructive sleep apnea syndrome , Monaldi Archives for Chest Disease: Vol. 87 No. 3 (2017)
- A.J. Lopes, T.T. Mafort, A. de Sá Ferreira, M.C. Santos de Castro, M. de Cássia Firmida, E. de Andrade Marques, Is the type of chronic pulmonary infection a determinant of lung function outcomes in adult patients with cystic fibrosis? , Monaldi Archives for Chest Disease: Vol. 77 No. 3-4 (2012): Pulmonary series
- N. Charokopos, M. Tsiamita, K. Karkoulias, R. Panagiota, D. Dougenis, K. Spiropoulos, Recurrent catamenial hemothorax , Monaldi Archives for Chest Disease: Vol. 61 No. 3 (2004): Pulmonary series
<< < 1 2 3 4 5 6 7 8 9 10 > >>
You may also start an advanced similarity search for this article.
