https://doi.org/10.4081/monaldi.2023.2488
When benign leiomyomas metastasize to the lungs - a case report
Submitted: November 19, 2022
Accepted: January 23, 2023
Published: February 3, 2023
Accepted: January 23, 2023
Abstract Views: 644
PDF: 136
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Benign metastasizing leiomyoma is a rare disease that primarily affects premenopausal women who have a history of uterine leiomyoma, which is characterized by pulmonary metastases. The pathogenesis of this condition is unknown. Patients are usually asymptomatic or have vague symptoms. Pathological examination in conjunction with immunohistochemistry is required for diagnosis. Treatment is determined by the patient's age, hormonal status, symptoms, and the extent of the lesions (number, size, and location of nodules), with surgical resection being the most effective. We present the case of a 72-year-old woman who had a total hysterectomy 30 years earlier due to myomas and developed a persistent dry cough. Her computed tomography of the chest revealed several small nodules in the pulmonary parenchyma. Because of the nodules' small size and difficult accessibility, a surgical biopsy was performed for histopathological examination and immunohistochemical staining, which revealed metastasizing leiomyoma. Letrozole treatment was started and was well tolerated.
Pacheco-Rodriguez G, Taveira-DaSilva AM, Moss J. Benign metastasizing leiomyoma. Clin Chest Med 2016;37:589–95.
DOI: https://doi.org/10.1016/j.ccm.2016.04.019
Fan R, Feng F, Yang H, et al. Pulmonary benign metastasizing leiomyomas: a case series of 23 patients at a single facility. BMC Pulm Med 2020;20:1–7.
DOI: https://doi.org/10.1186/s12890-020-01330-4
Barnas E, Ksiazek M, Ras R, et al. Benign metastasizing leiomyoma: A review of current literature in respect to the time and type of previous gynecological surgery. PLoS One 2017;12:e0175875.
DOI: https://doi.org/10.1371/journal.pone.0175875
Robboy SJ, Bentley RC, Butnor K, Anderson MC. Pathology and pathophysiology of uterine smooth-muscle tumors. Environ Health Perspect 2000;108:S779–84.
DOI: https://doi.org/10.1289/ehp.00108s5779
Mahmoud MS, Desai K, Nezhat FR. Leiomyomas beyond the uterus; benign metastasizing leiomyomatosis with paraaortic metastasizing endometriosis and intravenous leiomyomatosis: a case series and review of the literature. Arch Gynecol Obstet 2014;291:223–30.
DOI: https://doi.org/10.1007/s00404-014-3356-8
Kayser K, Zink S, Schneider T, et al. Benign metastasizing leiomyoma of the uterus: documentation of clinical, immunohistochemical and lectin-histochemical data of ten cases. Virchows Arch 2000;437:284–92.
DOI: https://doi.org/10.1007/s004280000207
Abramson S, Gilkeson RC, Goldstein JD, et al. Benign metastasizing leiomyoma: clinical, imaging, and pathologic correlation. AJR Am J Roentgenol 2001;176:1409-13.
DOI: https://doi.org/10.2214/ajr.176.6.1761409
Awonuga AO, Shavell VI, Imudia AN, et al. Pathogenesis of benign metastasizing leiomyoma: a review. Obstet Gynecol Surv 2010;65:189-95.
DOI: https://doi.org/10.1097/OGX.0b013e3181d60f93
Ahmad SZ, Anupama R, Vijaykumar DK. Benign metastasizing leiomyoma - case report and review of literature. Eur J Obstet Gynecol Reprod Biol 2011;159:240-1.
DOI: https://doi.org/10.1016/j.ejogrb.2011.07.017
Abu Saadeh F, Riain CO, Cormack CM, Gleeson N. Lung metastases from benign uterine leiomyoma: does 18-FDG-PET/CT have a role to play? Ir J Med Sci 2019;188:619-24.
DOI: https://doi.org/10.1007/s11845-018-1876-0
di Scioscio V di, Feraco P, Miglio L, et al. Benign metastasizing leiomyoma of the lung: PET findings. J Thorac Imaging 2009;24:41-4.
DOI: https://doi.org/10.1097/RTI.0b013e31818a0840
Chen S, Zhang Y, Zhang J, et al. Pulmonary benign metastasizing leiomyoma from uterine leiomyoma. World J Surg Oncol 2013;11:163.
DOI: https://doi.org/10.1186/1477-7819-11-163
Rivera JA, Christopoulos S, Small D, Trifiro M. Hormonal manipulation of benign metastasizing leiomyomas: report of two cases and review of the literature. J Clin Endocrinol Metab 2004;89:3183–8.
DOI: https://doi.org/10.1210/jc.2003-032021
Ottlakan A, Borda B, Lazar G, et al. Treatment decision based on the biological behavior of pulmonary benign metastasizing leiomyoma. J Thorac Dis 2016;8:E672–6.
DOI: https://doi.org/10.21037/jtd.2016.06.61
Vaquero ME, Magrina JF, Leslie KO. Uterine smooth-muscle tumors with unusual growth patterns. J Minim Invasive Gynecol 2009;16:263–8.
DOI: https://doi.org/10.1016/j.jmig.2009.01.013
How to Cite
Vieira Naia, Joana, Diana Pimenta, Anita Paiva, Rita Costa, Conceição Souto de Moura, Raquel Pereira, and João Filipe Cruz. 2023. “When Benign Leiomyomas Metastasize to the Lungs - a Case Report”. Monaldi Archives for Chest Disease 93 (4). https://doi.org/10.4081/monaldi.2023.2488.
Copyright (c) 2023 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Nabila Kanwal, Humza Thobani, Ainan Arshad, Priya Ashok Kumar, Fatima Amjad, Safia Awan, Muhammad Irfan, Factors predicting mortality among patients with COVID-19 associated hospital acquired pneumonia: insights from a tertiary care center , Monaldi Archives for Chest Disease: Vol. 93 No. 4 (2023)
- The Rehabilitation Complexity Scale for respiratory patients Italian network, The ability of the Rehabilitation Complexity Scale (RCS) to capture disability in respiratory patients admitted for in-hospital rehabilitation , Monaldi Archives for Chest Disease: Early Access
- Devika Tayal, Prabhpreet Sethi, Prerna Jain, Point-of-care test for tuberculosis: a boon in diagnosis , Monaldi Archives for Chest Disease: Vol. 94 No. 1 (2024)
- Marco Umberto Scaramozzino, Maurizia Festa, Guido Levi, Ubaldo Romeo Plastina, Giovanni Sapone, Correlation between gastroesophageal reflux disease lung volumes and exacerbation of bronchial asthma: Italian pilot observational retrospective study GERDAS , Monaldi Archives for Chest Disease: Vol. 94 No. 2 (2024)
- Diletta Innocenti, Chiara Castellani, Eleonora Masi, Valeria Galici, Letizia Macconi, Giovanni Taccetti, Can percussive intrapulmonary ventilation improve the efficacy of physiotherapy in children with cystic fibrosis? , Monaldi Archives for Chest Disease: Vol. 94 No. 1 (2024)
- Matteo Pernigo, Elisabetta Dinatolo, Marco Cirillo, Zean Mhagna, Alida Filippini, Fabiana Cozza, Marco Berti, Roberto Bazzani, Tony Sabatini, Claudio Cuccia, Giovanni Troise, Finger ischemia in a young lady: an unusual presentation of papillary fibroelastoma with intraventricular location , Monaldi Archives for Chest Disease: Vol. 94 No. 1 (2024)
- Martina Turrin, Francesca Maria Pontoriero, Giulia Grisostomi, Giordano Fiorentù, Francesca Zampieri, Francesca Savoia, Cosimo Catino, Giuseppe Zanardi, Piera Peditto, Nicola Malacchini, Fabiola Zeraj, Matteo Bonato, Diana Sacchi, Maria Guido, Giovanni Morana, Micaela Romagnoli, Tracheal atypical solitary carcinoid in a so-called “difficult asthma”: a diagnostic challenge , Monaldi Archives for Chest Disease: Vol. 94 No. 2 (2024)
- Mukesh Goyal, Jose K. Jimmy, Ramakant Dixit, Deepak Kumar Garg, A study of subcutaneous emphysema, factors contributing to its development, resolution and management with different modalities , Monaldi Archives for Chest Disease: Vol. 94 No. 2 (2024)
- Maya Gopalakrishnan, Satyendra Khichar, Suman Saurabh, Parag Vijayvergia, Karthikeyan Thangaraju, Swapnil Tripathi, Harshavardhan V. Devarakonda, Akhilesh Kumar , Pranav S. Kumar, Mahendra Kumar Garg , Effectiveness of early awake self proning strategy in non-intubated patients with COVID-19 hypoxemia: an open-labelled randomized clinical trial from Jodhpur, India , Monaldi Archives for Chest Disease: Vol. 93 No. 4 (2023)
- Devika Tayal, Prerna Jain, Mamta Bhardwaj, Amit Sharma, Diabetes mellitus in acute exacerbation of chronic obstructive pulmonary disease – the tip of the iceberg , Monaldi Archives for Chest Disease: Early Access
<< < 49 50 51 52 53 54 55 56 57 58 > >>
You may also start an advanced similarity search for this article.
