https://doi.org/10.4081/monaldi.2023.2499
Impact of immune status on the clinical characteristics, treatment outcomes and mortality of pulmonary nocardiosis: a retrospective analysis in a tertiary care hospital from a low- to middle-income country
Submitted: November 30, 2022
Accepted: June 7, 2023
Published: June 26, 2023
Accepted: June 7, 2023
Abstract Views: 714
PDF: 113
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Nocardiosis is an opportunistic infection that primarily targets the immunosuppressed. We investigated the differences in demographics and characteristics between immunosuppressed and immunocompetent patients with nocardiosis in a tertiary care hospital in Pakistan. Retrospective records were reviewed for patients diagnosed with pulmonary nocardiosis between 2010 and 2020. Immunosuppressed individuals were identified as those with autoimmune diseases, hematologic diseases and malignancies, HIV, immunosuppressant therapy, etc. Data collected included basic demographics, comorbid conditions, medication history, clinical presentation, radiological and microbiological data, and nocardiosis outcomes and complications. A total of 66 patients with nocardiosis were included in this study, of whom 48 were immunosuppressed and 18 were immunocompetent. Both groups were compared for a number of variables, including patient characteristics, underlying conditions, radiological findings, treatment regimen, and outcomes. Immunosuppressed individuals were younger and had higher rates of diabetes, chronic renal disease, chronic liver disease, higher platelet counts, surgical intervention, and longer hospital stays. Fever, dyspnea, and sputum production were the most common presentations. Nocardia asteroides was found to be the most common species of Nocardia overall. Nocardiosis presents differently in immunosuppressed and immunocompetent patients, which is consistent with previous studies. Nocardiosis should be considered in any patient presenting with treatment-resistant pulmonary or neurological symptoms.
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Ethics Approval
The study protocol was approved by the Ethical Review Committee (ERC) of Aga Khan University (ERC No: 2019-0801-1195).How to Cite
Zubair, Syed Muhammad, Muhammad Mustansir Mehdi Khan, Yasmin Rahim, Hamza Ahmed Ibad, and Muhammad Irfan. 2023. “Impact of Immune Status on the Clinical Characteristics, Treatment Outcomes and Mortality of Pulmonary Nocardiosis: A Retrospective Analysis in a Tertiary Care Hospital from a Low- to Middle-Income Country”. Monaldi Archives for Chest Disease 94 (2). https://doi.org/10.4081/monaldi.2023.2499.
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