https://doi.org/10.4081/monaldi.2023.2501
Long-term prognosis of out-of-hospital cardiac arrest due to idiopathic ventricular arrhythmias
Submitted: December 1, 2022
Accepted: January 22, 2023
Published: February 3, 2023
Accepted: January 22, 2023
Abstract Views: 1096
PDF: 160
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Life-threatening ventricular arrhythmias (VA) may occur in patients with unknown cardiac disease. A sizable part of them remains labeled as Idiopathic VA and limited data is available regarding their natural history. Our aim was to evaluate the long-term clinical outcomes of survivors of an idiopathic life-threatening VA. Patients who survived an idiopathic life-threatening VA referred to an ICD were included and followed for a median follow-up of 7 years. Clinical and device data were collected and a comparison between genders was made. A total of 29 patients, 41% female, mean age of 50 (19) years were studied; all were implanted with an ICD at index hospitalization. At follow-up, an etiological diagnosis was established in 38% of patients. Genetic testing improved the diagnosis and allowed the identification of a distinct clinical entity in 60% of patients (p=0.04, OR=7.0), especially in women. Regarding ICD data, 31% received appropriate therapies with a median time to first appropriate shock of 39 months (IQR 12-46 months). Men had a significantly higher prevalence of appropriated shocks (50% vs 8%, p=0.04), with a similar time to the first arrhythmic event between genders. Two of the patients died, both from non-arrhythmic causes. Etiologic diagnosis and recurrence prediction in patients with idiopathic VA is challenging, even with long-term follow-up and sophisticated diagnostic evaluation. Genetic testing significantly improved the diagnostic yield, especially in women. Arrhythmia recurrence occurred in about one-third of patients and is significantly higher in men, underscoring the importance of ICD implantation.
Bujak K, Nadolny K, Trzeciak P, Galazkowski R, Ladny JR, Gasior M. Does the presence of physician-staffed emergency medical service improve the prognosis in out-of-hospital cardiac arrest? A propensity score matching analysis. Kardiol Pol 2022;80:685-92.
DOI: https://doi.org/10.33963/KP.a2022.0109
Priori SG, Blomstrom-Lundqvist C, Mazzanti A, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J 2015;36:2793-867.
DOI: https://doi.org/10.1093/eurheartj/ehv316
Sip M, Puslecki M, Klosiewicz T, et al. A concept for the development of a pioneer regional Out-of-Hospital Cardiac Arrest Program to improve patient outcomes. Kardiol Pol 2020;78:875-81.
DOI: https://doi.org/10.33963/KP.15433
junttila mj, hookana e, kaikkonen ks, et al. Temporal trends in the clinical and pathological characteristics of victims of sudden cardiac death in the absence of previously identified heart disease. Circ Arrhythm Electrophysiol 2016;9:e003723.
DOI: https://doi.org/10.1161/CIRCEP.115.003723
Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol 2018;72:e91-e220.
Stepien-Wojno M, Poninska J, Rydzanicz M, et al. Sudden cardiac arrest in patients without overt heart disease: a limited value of next generation sequencing. Pol Arch Intern Med 2018;128:721-30.
DOI: https://doi.org/10.20452/pamw.4366
Knecht S, Sacher F, Wright M, et al. Long-term follow-up of idiopathic ventricular fibrillation ablation: a multicenter study. J Am Coll Cardiol 2009;54:522-8.
DOI: https://doi.org/10.1016/j.jacc.2009.03.065
Waldmann V, Bougouin W, Karam N, et al. Characteristics and clinical assessment of unexplained sudden cardiac arrest in the real-world setting: focus on idiopathic ventricular fibrillation. Eur Heart J 2018;39:1981-7.
DOI: https://doi.org/10.1093/eurheartj/ehy098
Krahn AD, Healey JS, Chauhan V, et al. Systematic assessment of patients with unexplained cardiac arrest: Cardiac Arrest Survivors With Preserved Ejection Fraction Registry (CASPER). Circulation 2009;120:278-85.
DOI: https://doi.org/10.1161/CIRCULATIONAHA.109.853143
Conte G, Giudicessi JR, Ackerman MJ. Idiopathic ventricular fibrillation: the ongoing quest for diagnostic refinement. Europace 2021;23:4-10.
DOI: https://doi.org/10.1093/europace/euaa211
Leenhardt A, Glaser E, Burguera M, et al. Short-coupled variant of torsade de pointes. A new electrocardiographic entity in the spectrum of idiopathic ventricular tachyarrhythmias. Circulation 1994;89:206-15.
DOI: https://doi.org/10.1161/01.CIR.89.1.206
Haissaguerre M, Shah DC, Jais P, et al. Role of Purkinje conducting system in triggering of idiopathic ventricular fibrillation. Lancet 2002;359:677-8.
DOI: https://doi.org/10.1016/S0140-6736(02)07807-8
Conte G, Belhassen B, Lambiase P, et al. Out-of-hospital cardiac arrest due to idiopathic ventricular fibrillation in patients with normal electrocardiograms: results from a multicentre long-term registry. Europace 2019;21:1670-7.
DOI: https://doi.org/10.1093/europace/euz221
Chaudhry U, Platonov PG, Rubulis A, et al. Idiopathic ventricular fibrillation - Long term prognosis in relation to clinical findings and ECG patterns in a Swedish cohort. J Electrocardiol 2019;56:46-51.
DOI: https://doi.org/10.1016/j.jelectrocard.2019.06.016
Rieder M, Giammarino L, Asatryan B, Odening KE. Sex differences in idiopathic VF: Evidence for sex-specific differences in proarrhythmic triggers. Heart Rhythm 2021;18:1655-6.
DOI: https://doi.org/10.1016/j.hrthm.2021.07.060
Surget E, Cheniti G, Ramirez FD, et al. Sex differences in the origin of Purkinje ectopy-initiated idiopathic ventricular fibrillation. Heart Rhythm 2021;18:1647-54.
DOI: https://doi.org/10.1016/j.hrthm.2021.07.007
Milman A, Gourraud JB, Andorin A, et al. Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients. Heart Rhythm 2018;15:1457-65.
DOI: https://doi.org/10.1016/j.hrthm.2018.06.019
How to Cite
Alves Pinto, Ricardo, Tânia Proença, Miguel Martins Carvalho, Sílvia Oliveira, Luis Adão, and Filipe Macedo. 2023. “Long-Term Prognosis of Out-of-Hospital Cardiac Arrest Due to Idiopathic Ventricular Arrhythmias”. Monaldi Archives for Chest Disease 93 (4). https://doi.org/10.4081/monaldi.2023.2501.
Copyright (c) 2023 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Maryam Hassan, Akbar Shoukat Ali, Ali Bin Sarwar Zubairi, Zahra Ali Padhani, Salman Kirmani, Huzaifa Ahmad, Zafar Fatmi, Jai K Das, Gene polymorphisms and risk of idiopathic pulmonary fibrosis: a systematic review and meta-analysis , Monaldi Archives for Chest Disease: Early Access
- Andrea Passantino, Pietro Guida, Caterina Rizzo, Rosa Carbonara, Roberta Ruggieri, Domenico Scrutinio, Malnutrition in patients admitted to in-hospital cardiac rehabilitation: Clinical correlates and association with mortality , Monaldi Archives for Chest Disease: Vol. 92 No. 2 (2022)
- Pompilio Faggiano, Francesco Fattirolli, Anna Frisinghelli, Lucrezia Piccioli, Nicolò Dasseni, Maria Vittoria Silverii, Laura Albricci, Giuseppe D'Ambrosio, Rosaria Garrì, Luigi Esposito, Francesco Giallauria, Secondary prevention advices after cardiovascular index event: From drug prescription to risk factors control in real world practice , Monaldi Archives for Chest Disease: Vol. 89 No. 2 (2019)
- Maria Grazia Romeo, Emanuele Pilato, Raffaele Giordano, Giuseppe Comentale, Gabriele Iannelli, Domenico Romeo, Bruna Miserrafiti, Luigi Di Tommaso, Asymptomatic giant ascending aortic aneurysm: a challenging surgical strategy for a silent bicuspid aortopathy , Monaldi Archives for Chest Disease: Early Access
- Ricardo Alves Pinto, Catarina Amaral Marques, Tânia Proença, Miguel Martins Carvalho, Cristina Cruz, Filipe Macedo, The world upside down – after 20 years of follow-up of dextro-transposition of the great arteries , Monaldi Archives for Chest Disease: Vol. 94 No. 1 (2024)
- Maurizio Santomauro, Mario Petretta, Carla Riganti, Mario Alberto Santomauro, Mariarosaria De Luca, Andrea Santomauro, Antonio Cittadini, Reduction of inappropriate shock rate through signal filtering (smart-pass) in patients with implantable subcutaneous cardioverter-defibrillator: a systematic review and meta-analysis , Monaldi Archives for Chest Disease: Early Access
- Filippo Brandimarte, Alessandro Battagliese, Silvana Petronilla Pirillo, Maria Teresa Mallus, Rosa Maria Manfredi, Giovanni Carreras, A case of arrhythmogenic right ventricular cardiomyopathy with biventricular involvement , Monaldi Archives for Chest Disease: Vol. 89 No. 1 (2019)
- Barbara Bordoni, Stefano Urbinati, Alicia Tosoni, Graziana Labanti, Alba Brandes, Cardiologic evaluation of patients undergoing chemoterapy , Monaldi Archives for Chest Disease: Vol. 82 No. 2 (2014): Cardiac series
- M. Malerba, G. Romanelli, Early cardiovascular involvement in Chronic Obstructive Pulmonary Disease , Monaldi Archives for Chest Disease: Vol. 71 No. 2 (2009): Pulmonary series
- Angelo Compare, Domenico Del Forno, Edward Callus, Francesco Giallauria, Alessandra Vitelli, Claudio Buccelli, Carlo Vigorito, Post-traumatic stress disorder, emotional processing and Inappropriate Implantable Cardioverter-Defibrillator Shocks: clinical consideration by a single case report , Monaldi Archives for Chest Disease: Vol. 78 No. 3 (2012): Cardiac series
<< < 10 11 12 13 14 15 16 17 18 19 > >>
You may also start an advanced similarity search for this article.
