https://doi.org/10.4081/monaldi.2023.2501
Long-term prognosis of out-of-hospital cardiac arrest due to idiopathic ventricular arrhythmias
Submitted: December 1, 2022
Accepted: January 22, 2023
Published: February 3, 2023
Accepted: January 22, 2023
Abstract Views: 1096
PDF: 160
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Life-threatening ventricular arrhythmias (VA) may occur in patients with unknown cardiac disease. A sizable part of them remains labeled as Idiopathic VA and limited data is available regarding their natural history. Our aim was to evaluate the long-term clinical outcomes of survivors of an idiopathic life-threatening VA. Patients who survived an idiopathic life-threatening VA referred to an ICD were included and followed for a median follow-up of 7 years. Clinical and device data were collected and a comparison between genders was made. A total of 29 patients, 41% female, mean age of 50 (19) years were studied; all were implanted with an ICD at index hospitalization. At follow-up, an etiological diagnosis was established in 38% of patients. Genetic testing improved the diagnosis and allowed the identification of a distinct clinical entity in 60% of patients (p=0.04, OR=7.0), especially in women. Regarding ICD data, 31% received appropriate therapies with a median time to first appropriate shock of 39 months (IQR 12-46 months). Men had a significantly higher prevalence of appropriated shocks (50% vs 8%, p=0.04), with a similar time to the first arrhythmic event between genders. Two of the patients died, both from non-arrhythmic causes. Etiologic diagnosis and recurrence prediction in patients with idiopathic VA is challenging, even with long-term follow-up and sophisticated diagnostic evaluation. Genetic testing significantly improved the diagnostic yield, especially in women. Arrhythmia recurrence occurred in about one-third of patients and is significantly higher in men, underscoring the importance of ICD implantation.
Bujak K, Nadolny K, Trzeciak P, Galazkowski R, Ladny JR, Gasior M. Does the presence of physician-staffed emergency medical service improve the prognosis in out-of-hospital cardiac arrest? A propensity score matching analysis. Kardiol Pol 2022;80:685-92.
DOI: https://doi.org/10.33963/KP.a2022.0109
Priori SG, Blomstrom-Lundqvist C, Mazzanti A, et al. 2015 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: The Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC). Eur Heart J 2015;36:2793-867.
DOI: https://doi.org/10.1093/eurheartj/ehv316
Sip M, Puslecki M, Klosiewicz T, et al. A concept for the development of a pioneer regional Out-of-Hospital Cardiac Arrest Program to improve patient outcomes. Kardiol Pol 2020;78:875-81.
DOI: https://doi.org/10.33963/KP.15433
junttila mj, hookana e, kaikkonen ks, et al. Temporal trends in the clinical and pathological characteristics of victims of sudden cardiac death in the absence of previously identified heart disease. Circ Arrhythm Electrophysiol 2016;9:e003723.
DOI: https://doi.org/10.1161/CIRCEP.115.003723
Al-Khatib SM, Stevenson WG, Ackerman MJ, et al. 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society. J Am Coll Cardiol 2018;72:e91-e220.
Stepien-Wojno M, Poninska J, Rydzanicz M, et al. Sudden cardiac arrest in patients without overt heart disease: a limited value of next generation sequencing. Pol Arch Intern Med 2018;128:721-30.
DOI: https://doi.org/10.20452/pamw.4366
Knecht S, Sacher F, Wright M, et al. Long-term follow-up of idiopathic ventricular fibrillation ablation: a multicenter study. J Am Coll Cardiol 2009;54:522-8.
DOI: https://doi.org/10.1016/j.jacc.2009.03.065
Waldmann V, Bougouin W, Karam N, et al. Characteristics and clinical assessment of unexplained sudden cardiac arrest in the real-world setting: focus on idiopathic ventricular fibrillation. Eur Heart J 2018;39:1981-7.
DOI: https://doi.org/10.1093/eurheartj/ehy098
Krahn AD, Healey JS, Chauhan V, et al. Systematic assessment of patients with unexplained cardiac arrest: Cardiac Arrest Survivors With Preserved Ejection Fraction Registry (CASPER). Circulation 2009;120:278-85.
DOI: https://doi.org/10.1161/CIRCULATIONAHA.109.853143
Conte G, Giudicessi JR, Ackerman MJ. Idiopathic ventricular fibrillation: the ongoing quest for diagnostic refinement. Europace 2021;23:4-10.
DOI: https://doi.org/10.1093/europace/euaa211
Leenhardt A, Glaser E, Burguera M, et al. Short-coupled variant of torsade de pointes. A new electrocardiographic entity in the spectrum of idiopathic ventricular tachyarrhythmias. Circulation 1994;89:206-15.
DOI: https://doi.org/10.1161/01.CIR.89.1.206
Haissaguerre M, Shah DC, Jais P, et al. Role of Purkinje conducting system in triggering of idiopathic ventricular fibrillation. Lancet 2002;359:677-8.
DOI: https://doi.org/10.1016/S0140-6736(02)07807-8
Conte G, Belhassen B, Lambiase P, et al. Out-of-hospital cardiac arrest due to idiopathic ventricular fibrillation in patients with normal electrocardiograms: results from a multicentre long-term registry. Europace 2019;21:1670-7.
DOI: https://doi.org/10.1093/europace/euz221
Chaudhry U, Platonov PG, Rubulis A, et al. Idiopathic ventricular fibrillation - Long term prognosis in relation to clinical findings and ECG patterns in a Swedish cohort. J Electrocardiol 2019;56:46-51.
DOI: https://doi.org/10.1016/j.jelectrocard.2019.06.016
Rieder M, Giammarino L, Asatryan B, Odening KE. Sex differences in idiopathic VF: Evidence for sex-specific differences in proarrhythmic triggers. Heart Rhythm 2021;18:1655-6.
DOI: https://doi.org/10.1016/j.hrthm.2021.07.060
Surget E, Cheniti G, Ramirez FD, et al. Sex differences in the origin of Purkinje ectopy-initiated idiopathic ventricular fibrillation. Heart Rhythm 2021;18:1647-54.
DOI: https://doi.org/10.1016/j.hrthm.2021.07.007
Milman A, Gourraud JB, Andorin A, et al. Gender differences in patients with Brugada syndrome and arrhythmic events: Data from a survey on arrhythmic events in 678 patients. Heart Rhythm 2018;15:1457-65.
DOI: https://doi.org/10.1016/j.hrthm.2018.06.019
How to Cite
Alves Pinto, Ricardo, Tânia Proença, Miguel Martins Carvalho, Sílvia Oliveira, Luis Adão, and Filipe Macedo. 2023. “Long-Term Prognosis of Out-of-Hospital Cardiac Arrest Due to Idiopathic Ventricular Arrhythmias”. Monaldi Archives for Chest Disease 93 (4). https://doi.org/10.4081/monaldi.2023.2501.
Copyright (c) 2023 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Shekhar Kunal, Vijay Pathak, Keshav Pathak, Monika Mishra, Shashi Mohan Sharma, Sudhir Bhandari, Very late stent thrombosis associated with COVID-19 infection: a case report and review of the literature , Monaldi Archives for Chest Disease: Vol. 92 No. 2 (2022)
- Giuliana Cimino, Enrico Vizzardi, Emiliano Calvi, Edoardo Pancaldi, Greta Pascariello, Nicola Bernardi, Angelica Cersosimo, Ludovica Amore, Riccardo M. Inciardi, Riccardo Raddino, Marco Metra, Endothelial dysfunction in COVID-19 patients assessed with Endo-PAT2000 , Monaldi Archives for Chest Disease: Vol. 92 No. 4 (2022)
- Diana Alexandra Gonçalves Pimenta, Renata Carvalho, Raquel Pereira, Rui Rolo, Lurdes Ferreira, Interstitial nephritis secondary to treatment with pembrolizumab, a rare complication in two patients with lung adenocarcinoma , Monaldi Archives for Chest Disease: Vol. 93 No. 2 (2023)
- Abdalla Eltayeb, Shahid Khan, Salam Dib, Ali Musthaq, Ahmed Elshaer, Abdullah Shaik, Domenico Galzerano, Bahaa Fadel, Mohamed Aladmawi, Olga Vriz, Three-dimensional printing in integrated multi-modality imaging approach for management of prosthetic valves infective endocarditis , Monaldi Archives for Chest Disease: Vol. 93 No. 4 (2023)
- Amitesh Gupta, Eshutosh Chandra, Shipra Anand, Naresh Kumar, Richa Arora, Divyanshi Rana, Parul Mrigpuri, Latent tuberculosis diagnostics: current scenario and review , Monaldi Archives for Chest Disease: Early Access
- Ugo Corrà , Massimo Pistono, Early mobilization in LVAD recipients: An obligatory step towards recovery , Monaldi Archives for Chest Disease: Vol. 89 No. 1 (2019)
- Gian Francesco Mureddu, Cesare Greco, Stefano Rosato, Paola D'Errigo, Leonardo De Luca, Gabriella Badoni, Pompilio Faggiano, Fulvia Seccareccia, High thrombotic risk increases adverse clinical events up to 5 years after acute myocardial infarction. A nationwide retrospective cohort study , Monaldi Archives for Chest Disease: Vol. 89 No. 3 (2019)
- Kamal Kant Sahu, Ajay Kumar Mishra, Kevin Martin, Iryna Chastain, COVID-19 and restrictive lung disease: A deadly combo to trip off the fine balance , Monaldi Archives for Chest Disease: Vol. 90 No. 2 (2020)
- Laura Pini, Laura Tiberio, Marianna Arici, Luciano Corda, Jordan Giordani, Elena Bargagli, Claudio Tantucci, Z-alpha1-antitrypsin polymers and small airways disease: a new paradigm in alfa-1 anti-trypsin deficiency-related COPD development? , Monaldi Archives for Chest Disease: Vol. 91 No. 4 (2021)
- Ankita Mandal, Ajay Kumar Verma, Sujit Kumar Kar, Jyoti Bajpai, Surya Kant, Santosh Kumar, Ram Avadh Singh Kushwaha, Rajiv Garg, Anand Srivastava, Darshan Kumar Bajaj, Sanjeev Kumar Verma, Shyam Chand Chaudhary, A cross-sectional study to determine the psychological distress among pulmonary tuberculosis patients during COVID-19 pandemic , Monaldi Archives for Chest Disease: Vol. 93 No. 1 (2023)
<< < 47 48 49 50 51 52 53 54 55 > >>
You may also start an advanced similarity search for this article.
