https://doi.org/10.4081/monaldi.2023.2632
Overcoming the challenges of a misdiagnosed rare lung disease – idiopathic pleuroparenchymal fibroelastosis
Submitted: May 8, 2023
Accepted: June 26, 2023
Published: August 2, 2023
Accepted: June 26, 2023
Abstract Views: 1207
PDF: 62
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Pleuroparenchymal fibroelastosis (PPFE) is a rare condition characterized by pleural and subpleural lung fibroelastosis with an upper lobe predominance. We present the third case of idiopathic PPFE from India, as well as the second ante-mortem diagnosis. A 27-year-old man presented with a 1-year history of modified Medical Research Council class II shortness of breath and dry cough. He described a 15-kg weight loss. After a clinico-radiological diagnosis, he was given anti-tubercular treatment and referred because he showed no improvement. A high-resolution computed tomography of the chest revealed bilateral upper lobe bullae, parenchymal and subpleural fibrosis, and irregular pleural thickening. PPFE was found in surgical lung and pleural biopsies. He was given systemic glucocorticoids but did not respond clinically or radiologically. Pirfenidone and a lung transplant were out of reach for him. He died 9 months after being diagnosed with his condition. Finally, idiopathic PPFE is an extremely rare entity, with only three cases reported from our subcontinent. As a result, it is easily underdiagnosed or misdiagnosed; clinician awareness of this condition is critical for better diagnosis and management.
Thangakunam B, Isaac BTJ, Christopher DJ, Burad D. Idiopathic pleuroparenchymal fibroelastosis – a rare idiopathic interstitial pneumonia. Respir Med Case Rep 2016;17:8-11.
Maturu VN, Rajendran P, Narahari NK. Idiopathic pleuroparenchymal fibroelastosis presenting as bilateral spontaneous pneumothorax: a case report. Lung India 2019;36:75-7.
Bhaskar M, Tisekar O, Tandon S, et al. Rapidly progressive pleuro-parenchymal fibroelastosis secondary to cyclophosphamide chemotherapy. Indian J Med Paediatr Oncol 2020;41:427-9.
Fukada A, Suzuki Y, Mori K, et al. Idiopathic pleuroparenchymal fibroelastosis: three-dimensional computed tomography assessment of upper-lobe lung volume. Eur Respir J 2022;60:2200637.
Kinoshita Y, Kushima H, Ishii H. Idiopathic pleuroparenchymal fibroelastosis. BMJ Case Rep 2022;15:e251483.
Kinoshita Y, Miyamura T, Ikeda T, et al. Limited efficacy of nintedanib for idiopathic pleuroparenchymal fibroelastosis. Respir Investig 2022;60:562-9.
Boerner EB, Costabel U, Wessendorf TE, et al. Idiopathic pleuroparenchymal fibroelastosis (PPFE) – a case study of a rare entity. Rev Port Pneumol Engl Ed 2017;23:352-5.
Amitani R. Idiopathic pulmonary upper lobe fibrosis (IPUF). Kokyu 1992;11:693-9.
Frankel SK, Cool CD, Lynch DA, Brown KK. Idiopathic pleuroparenchymal fibroelastosis: description of a novel clinicopathologic entity. Chest 2004;126:2007-13.
Konen E, Weisbrod GL, Pakhale S, et al. Fibrosis of the upper lobes: a newly identified late-onset complication after lung transplantation?. AJR Am J Roentgenol 2003;181:1539-43.
Jacob J, Odink A, Brun AL, et al. Functional associations of pleuroparenchymal fibroelastosis and emphysema with hypersensitivity pneumonitis. Respir Med 2018;138:95-101.
Enomoto Y, Nakamura Y, Colby TV, et al. Radiologic pleuroparenchymal fibroelastosis-like lesion in connective tissue disease-related interstitial lung disease. PLoS One 2017;12:e0180283.
Xu L, Rassaei N, Caruso C. Pleuroparenchymal fibroelastosis with long history of asbestos and silicon exposure. Int J Surg Pathol 2018;26:190-3.
Reddy TL, Tominaga M, Hansell DM, et al. Pleuroparenchymal fibroelastosis: a spectrum of histopathological and imaging phenotypes. Eur Respir J 2012;40:377-85.
Watanabe K, Ishii H, Kiyomi F, et al. Criteria for the diagnosis of idiopathic pleuroparenchymal fibroelastosis: a proposal. Respir Investig 2019;57:312-20.
Cuppens K, Verbeken E, Coolen J, et al. Idiopathic pleuroparenchymatous fibroelastosis: a case report and brief review of the literature. Respir Med Case Rep 2014;12:7-9.
Becker CD, Gil J, Padilla ML. Idiopathic pleuroparenchymal fibroelastosis: an unrecognized or misdiagnosed entity?. Mod Pathol 2008;21:784-7.
Shioya M, Otsuka M, Yamada G, et al. Poorer prognosis of idiopathic pleuroparenchymal fibroelastosis compared with idiopathic pulmonary fibrosis in advanced stage. Can Respir J 2018;2018:6043053.
Sato S, Hanibuchi M, Takahashi M, et al. A patient with idiopathic pleuroparenchymal fibroelastosis showing a sustained pulmonary function due to treatment with pirfenidone. Intern Med 2016;55:497-501.
Nasser M, Chebib N, Philit F, et al. Treatment with nintedanib in patients with pleuroparenchymal fibroelastosis. Eur Respir J 2017;50:PA4876.
How to Cite
Garg, Shivam, Pratap Upadhya, Arul Kumar, Norton Stephen, and Bala Subramanian. 2023. “Overcoming the Challenges of a Misdiagnosed Rare Lung Disease – Idiopathic Pleuroparenchymal Fibroelastosis”. Monaldi Archives for Chest Disease 94 (2). https://doi.org/10.4081/monaldi.2023.2632.
Copyright (c) 2023 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Manas Mengar, Nitesh Gupta, Shibdas Chakrabarti, Vipin Aggarwal, Kalindi Shah, Pranav Ish, Cocaine abuse induced diffuse alveolar haemorrhage: a rare entity , Monaldi Archives for Chest Disease: Vol. 90 No. 1 (2020)
- Alexandru Stoichita, Andreea Dumitrescu, Ana Ciobanu, Cristian Oancea, Fildan Petronela, Radu Dabja, Kostyantyn Dumchev, Andrei Dadu, Beatrice Mahler-Boca, Kristina Akopyan, Depression and anxiety symptoms among people with rifampicin-resistant tuberculosis receiving in-patient care in the National Pulmonology Reference Institute in Romania , Monaldi Archives for Chest Disease: Vol. 91 No. 1 (2021)
- Cengiz Özdemir, Sinem Nedime Sökücü, Ayşegül Akbaş, Sezin Altay, Ahmet Levent Karasulu, Levent Dalar, Endobronchial Watanabe Spigot in the treatment of bronchobiliary fistula , Monaldi Archives for Chest Disease: Vol. 81 No. 1-2 (2015): Pulmonary series
- Pratap Upadhya, Rohit Vadala, Arpitha A, Hospital treatment of severe acute exacerbation of chronic obstructive pulmonary disease in COVID-19 situation: back to basics , Monaldi Archives for Chest Disease: Vol. 90 No. 4 (2020)
- Evangelos Balis, Sotiris Kakavas, Steven Kompogiorgas, Konstantinos Kotsifas, Georgios Boulbasakos, Presentation of pulmonary tuberculosis and actinomyces co-infection as a lung mass: a literature review and unique case report , Monaldi Archives for Chest Disease: Vol. 89 No. 3 (2019)
- Gaia Cipolla, Rosalba Relo, Elisa Pasciuta, Domenica Catalano, Federica Lo Bello, Irene Coppolino, Paolo Ruggeri, Alfio Proietto, Maria Buccafusca, Paola Maria Cutroneo, Gianluca Trifirò, Gaetano Caramori, A case of lung injury resembling diffuse pulmonary hemorrhage after the first administration of alemtuzumab in a patient with multiple sclerosis. Role of the HRCT , Monaldi Archives for Chest Disease: Vol. 90 No. 3 (2020)
- Rafael Martínez-Girón, Liron Pantanowitz, Pulmonary actinomycosis: cytomorphological features , Monaldi Archives for Chest Disease: Vol. 92 No. 2 (2022)
- Dimitrios Papadopoulos, Vlasios Skopas, Nikolaos Trakas, Eleni Papaefstathiou, Nikolaos Tzogas, Demosthenes Makris, Zoe Daniil, Konstantinos Gourgoulianis, Serum lactate dehydrogenase and its isoenzymes as predictors of clinical outcomes in acute exacerbation of chronic obstructive pulmonary disease: a retrospective analysis of a hospitalized cohort , Monaldi Archives for Chest Disease: Vol. 94 No. 2 (2024)
- Angelica Cersosimo, Gianmarco Arabia, Enrico Vizzardi, Marco Metra, Rapid progression of pulmonary artery dilatation in pulmonary hypertension , Monaldi Archives for Chest Disease: Vol. 93 No. 2 (2023)
- Pramod Chaudhari, Pawan Kumar Singh, Manjunath Govindagoudar, Vinod Sharma, Puneet Saxena, Aman Ahuja, Lokesh Lalwani, Dhruva Chaudhry, Utility and timing of the respiratory rate-oxygenation index in the prediction of high-flow oxygen therapy failure in acute hypoxemic respiratory failure of infective etiology: a prospective observational study , Monaldi Archives for Chest Disease: Vol. 94 No. 1 (2024)
<< < 25 26 27 28 29 30 31 32 33 34 > >>
You may also start an advanced similarity search for this article.
