https://doi.org/10.4081/monaldi.2023.2640
Correlation between gastroesophageal reflux disease lung volumes and exacerbation of bronchial asthma: Italian pilot observational retrospective study GERDAS
Submitted: May 16, 2023
Accepted: June 7, 2023
Published: June 15, 2023
Accepted: June 7, 2023
Abstract Views: 919
PDF: 312
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Reflux asthma is an entity characterized by typical symptoms and, in some cases, is “silent”; it is more dangerous when associated with obesity and sleep apnea syndrome. Numerous studies demonstrate its high prevalence in the general population, particularly in the pediatric population, where, despite medical specialists’ treatment, asthma symptoms remain poorly controlled with a high risk of acute exacerbations. This clinical study aims to show how the addition of a particular type of alginate (Deflux Plus sachets) containing hyaluronic acid and melatonin at low doses administered over a prolonged period of 6 months causes a reduction in vagal reflex stimulation of the esophagus and pulmonary microaspiration reflexes by regulating lower esophageal sphincter motility in asthmatic patients, improving the asthma control test (ATC) score. In the reported statistical analysis, receiver operating characteristic curves were performed for sensitivity and specificity for the analyzed parameters, including the ACT score, with statistically significant data p<0.0001. We conclude that combining conventional therapy for reflux asthma with alginates may improve the risk of acute asthma exacerbations and dynamic lung volumes.
Kim SY, Kim HR, Min C, et al. Bidirectional association between GERD and asthma in children: two longitudinal follow-up studies using a national sample cohort. Pediatr Res 2020;88:320-4.
Mujica VR, Rao SS. Recognizing atypical manifestations of GERD. Asthma, chest pain, and otolaryngologic disorders may be due to reflux. Postgrad Med 1999;105:53-5, 50, 63-6.
Althoff MD, Ghincea A, Wood LG, et al. Asthma and three colinear comorbidities: obesity, OSA, and GERD. J Allergy Clin Immunol Pract 2021;9:3877-84.
Cazzola M, Rogliani P, Ora J, et al. Asthma and comorbidities: recent advances. Pol Arch Intern Med 2022;132:16250.
Shigemitsu H, Afshar K. Nocturnal asthma. Curr Opin Pulm Med 2007;13:49-55. Erratum in: Curr Opin Pulm Med 2007;13:156-7.
Gupta S, Lodha R, Kabra SK. Asthma, GERD and obesity: triangle of inflammation. Indian J Pediatr 2018;85:887-92.
Theodoropoulos DS, Pecoraro DL, Efstratiadis SE. The association of gastroesophageal reflux disease with asthma and chronic cough in the adult. Am J Respir Med 2002;1:133-46.
Field SK. Gastroesophageal reflux and asthma: can the paradox be explained?. Can Respir J 2000;7:167-76.
Sontag SJ. Gastroesophageal reflux and asthma. Am J Med 1997;103:84S-90S.
Sopo SM, Radzik D, Calvani M. Does treatment with proton pump inhibitors for gastroesophageal reflux disease (GERD) improve asthma symptoms in children with asthma and GERD? A systematic review. J Investig Allergol Clin Immunol 2009;19:1-5.
McCallister JW, Parsons JP, Mastronarde JG. The relationship between gastroesophageal reflux and asthma: an update. Ther Adv Respir Dis 2011;5:143-50.
Kilic M, Ozturk F, Kirmemis O, et al. Impact of laryngopharyngeal and gastroesophageal reflux on asthma control in children. Int J Pediatr Otorhinolaryngol 2013;77:341-5.
Alexander JA, Hunt LW, Patel AM. Prevalence, pathophysiology, and treatment of patients with asthma and gastroesophageal reflux disease. Mayo Clin Proc 2000;75:1055-63.
Naik RD, Vaezi MF. Extra-esophageal gastroesophageal reflux disease and asthma: understanding this interplay. Expert Rev Gastroenterol Hepatol 2015;9:969-82.
Mallah N, Turner JM, González-Barcala FJ, Takkouche B. Gastroesophageal reflux disease and asthma exacerbation: A systematic review and meta-analysis. Pediatr Allergy Immunol 2022;33:e13655.
Global Initiative for Asthma. 2022 GINA report, global strategy for asthma management and prevention. Available from: https://ginasthma.org/gina-reports/.
Griffiths TL, Nassar M, Soubani AO. Pulmonary manifestations of gastroesophageal reflux disease. Expert Rev Respir Med 2020;14:767-75.
Rogers L. Role of sleep apnea and gastroesophageal reflux in severe asthma. Immunol Allergy Clin North Am 2016;36:461-71.
Kasasbeh A, Kasasbeh E, Krishnaswamy G. Potential mechanisms connecting asthma, esophageal reflux, and obesity/sleep apnea complex--a hypothetical review. Sleep Med Rev 2007;11:47-58.
Mahdavinia M, Bishehsari F, Hayat W, et al. Prevalence of allergic rhinitis and asthma in patients with chronic rhinosinusitis and gastroesophageal reflux disease. Ann Allergy Asthma Immunol 2016;117:158-62.e1.
Harding SM. Acid reflux and asthma. Curr Opin Pulm Med 2003;9:42-5.
Broers C, Tack J, Pauwels A. Review article: gastro-oesophageal reflux disease in asthma and chronic obstructive pulmonary disease. Aliment Pharmacol Ther 2018;47:176-91.
Benich JJ 3rd, Carek PJ. Evaluation of the patient with chronic cough. Am Fam Physician 2011 15;84:887-92.
Szentivaneji A, Goldman AL. Vagotonia and bronchial asthma. Chest 1997;111:8-11.
Shirai T, Mikamo M, Tsuchiya T, et al. Real-world effect of gastroesophageal reflux disease on cough-related quality of life and disease status in asthma and COPD. Allergol Int 2015;64:79-83.
Parsons JP, Mastronarde JG. Gastroesophageal reflux disease and asthma. Curr Opin Pulm Med 2010;16:60-3.
Theodoropoulos DS, Lockey RF, Boyce HW Jr, Bukantz SC. Gastroesophageal reflux and asthma: a review of pathogenesis, diagnosis, and therapy. Allergy 1999;54:651-61.
Blake K, Teague WG. Gastroesophageal reflux disease and childhood asthma. Curr Opin Pulm Med 2013;19:24-9.
Thakkar K, Boatright RO, Gilger MA, El-Serag HB. Gastroesophageal reflux and asthma in children: a systematic review. Pediatrics 2010;125:e925-30.
How to Cite
Scaramozzino, Marco Umberto, Maurizia Festa, Guido Levi, Ubaldo Romeo Plastina, and Giovanni Sapone. 2023. “Correlation Between Gastroesophageal Reflux Disease Lung Volumes and Exacerbation of Bronchial Asthma: Italian Pilot Observational Retrospective Study GERDAS”. Monaldi Archives for Chest Disease 94 (2). https://doi.org/10.4081/monaldi.2023.2640.
Copyright (c) 2023 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- D. Eleftheriou, S. Katsenos, S. Zorbas, I. Griveas, K. Psathakis, Pulmonary fibrosis presenting as an early manifestation of microscopic polyangiitis , Monaldi Archives for Chest Disease: Vol. 77 No. 3-4 (2012): Pulmonary series
- R. Agarwal, N. Singh, A.N. Aggarwal, An unusual association between Mycobacterium tuberculosis and Aspergillus fumigatus , Monaldi Archives for Chest Disease: Vol. 69 No. 1 (2008): Pulmonary series
- Barbara Bordoni, Stefano Urbinati, Alicia Tosoni, Graziana Labanti, Alba Brandes, Cardiologic evaluation of patients undergoing chemoterapy , Monaldi Archives for Chest Disease: Vol. 82 No. 2 (2014): Cardiac series
- G. Ferrante, M. Simoni, F. Cibella, F. Ferrara, G. Liotta, V. Malizia, G. Corsello, G. Viegi, S. La Grutta, Third-hand smoke exposure and health hazards in children , Monaldi Archives for Chest Disease: Vol. 79 No. 1 (2013): Pulmonary series
- R. Louis, Induced sputum: not only for research but also for better patient management in asthma and COPD , Monaldi Archives for Chest Disease: Vol. 77 No. 1 (2012): Pulmonary series
- Sotirios Moraitis, Apostolos Perelas, Panagiotis Hountis, Dimitrios Moraitis, Maria Chounti, Eirini Rogdaki, Two foreign bodies embedded in the intraventricular septum: A case report , Monaldi Archives for Chest Disease: Vol. 87 No. 1 (2017)
- Carlo Lesi, Ester Giaquinto, Luca Valeriani, Luisa Zoni, Diet prescription in obese patients , Monaldi Archives for Chest Disease: Vol. 64 No. 1 (2005): Cardiac series
- Rupi Jamwal, Dinesh Singh Kushwaha, Charu Paruthi, Yatish Agarwal, Baljeet Singh Virk, Malini R. Capoor, Comparative analysis of airway invasive aspergillosis and endobronchial spread of tuberculosis on high resolution computed tomography , Monaldi Archives for Chest Disease: Vol. 93 No. 3 (2023)
- Martina Vigorè, Nicolo Granata, Giovanna Callegari, Raffaella Vaninetti, Simona Conti, Roberto Maestri, Giancarlo Piaggi, Gioele Cremonese, Antonia Pierobon, Frailty and rehabilitation outcome in older patients with cardiorespiratory disease: preliminary multidimensional data , Monaldi Archives for Chest Disease: Vol. 93 No. 4 (2023)
- Shivam Garg, Vishnukanth Govindaraj, Dharm Prakash Dwivedi, Kalayarasan Raja, Elamurugan Palanivel Theerthar, Postoperative pulmonary complications in patients undergoing upper abdominal surgery: risk factors and predictive models , Monaldi Archives for Chest Disease: Early Access
<< < 18 19 20 21 22 23 24 25 26 27 > >>
You may also start an advanced similarity search for this article.
