https://doi.org/10.4081/monaldi.2023.2652

Utility of systemic immune-inflammation index as a serum biomarker to differentiate between complicated and simple para-pneumonic effusion

Vol. 94 No. 3 (2024)
Submitted: June 2, 2023
Accepted: August 28, 2023
Published: September 7, 2023
Pneumonia, parapneumonic effusion, systemic immune-inflammation index
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Authors

Nikhil Rajvanshi
https://orcid.org/0000-0002-0787-8815
Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Prawin Kumar
https://orcid.org/0000-0002-2365-8097
Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.
Jagdish Prasad Goyal
jpgoyal@rediffmail.com
https://orcid.org/0000-0002-7198-6909
Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India.

The systemic immune-inflammation index (SII) is a novel inflammatory biomarker. Simple and complicated para-pneumonic effusion (PPE) are two significant complications of pneumonia. We evaluated the efficacy of the SII to differentiate between the two. Records of all children up to 18 years of age admitted between April 2019 and September 2022 and diagnosed with simple or complicated PPE were retrospectively evaluated. SII and other biomarkers were compared between both groups. Receiver operating characteristics with the Youden index were used to estimate the discriminative value of SII. 50 children were enrolled with a median (interquartile range) age of 81.5 (36.7, 133.5) months; 31 (62%) were male. 31 (62%) had complicated PPE, and 19 (38%) had simple PPE. SII was significantly higher in complicated PPE (p=0.007). Good areas under the curve were found for C-reactive protein (0.771) and SII (0.736) to differentiate complicated from simple PPE. The best cut-off value for SII to differentiate complicated PPE from simple PPE was 1557×103μL, with a sensitivity of 82.4% and specificity of 57.6%. SII can be used as a screening tool to differentiate between complicated and simple PPE at the time of presentation.

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Ethics Approval

The study protocol was approved by the Ethical Review Committee of the All India Institute of Medical Sciences, Jodhpur No. AIIMS/IEC/2019/1766.

How to Cite

Rajvanshi, Nikhil, Prawin Kumar, and Jagdish Prasad Goyal. 2023. “Utility of Systemic Immune-Inflammation Index As a Serum Biomarker to Differentiate Between Complicated and Simple Para-Pneumonic Effusion”. Monaldi Archives for Chest Disease 94 (3). https://doi.org/10.4081/monaldi.2023.2652.
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