https://doi.org/10.4081/monaldi.2023.2660
Sleep-disordered breathing and heart failure: a vicious cycle of cardiovascular risk
Submitted: June 11, 2023
Accepted: August 10, 2023
Published: September 1, 2023
Accepted: August 10, 2023
Abstract Views: 1103
PDF: 72
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Sleep-disordered breathing (SDB) represents an important cardiovascular risk factor that is still often underestimated and not always optimally treated. Such breathing disorders can induce several harmful effects on the heart, also favoring the development of arrhythmias, ischemic heart disease, and left ventricular remodeling. Obstructive sleep apnea syndrome (OSA) is more frequent in heart failure patients than in the general population, promoting the worsening of left ventricular dysfunction. Both sleep apnea and heart failure have common clinical manifestations but also similar neurohormonal characteristics, contributing to the development and progression of heart failure and resulting in increased mortality. The pathophysiological mechanisms underlying left ventricular dysfunction associated with SDB will be analyzed, and the potential therapeutic effects of gliflozins on OSA in heart failure patients will be discussed.
Redline S, Foody J. Sleep disturbances: time to join the top 10 potentially modifiable cardiovascular risk factors?. Circulation 2011;124:2049-51.
Lyons OD, Bradley TD. Heart failure and sleep apnea. Can J Cardiol 2015;31:898-908.
Javaheri S. Sleep disorders in systolic heart failure: a prospective study of 100 male patients. The final report. Int J Cardiol 2006;106:21-8.
Vazir A, Hastings PC, Dayer M, et al. A high prevalence of sleep disordered breathing in men with mild symptomatic chronic heart failure due to left ventricular systolic dysfunction. Eur J Heart Fail 2007;9:243-50.
Kasai T, Bradley TD. Obstructive sleep apnea and heart failure: pathophysiologic and therapeutic implications. J Am Coll Cardiol 2011;57:119-27.
Marin JM, Carrizo SJ, Vicente E, et al. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 2005;365:1046-53.
Arzt M, Floras JS, Logan AG, et al. Suppression of central sleep apnea by continuous positive airway pressure and transplant-free survival in heart failure: a post hoc analysis of the Canadian continuous positive airway pressure for patients with central sleep apnea and heart failure trial (CANPAP). Circulation 2007;115:3173-80.
Cowie MR, Woehrle H, Wegscheider K, et al. Adaptive servo-ventilation for central sleep apnea in systolic heart failure. N Engl J Med 2015;373:1095-105.
Jaffuel D, Nogue E, Berdague P, et al. Sacubitril-valsartan initiation in chronic heart failure patients impacts sleep apnea: the ENTRESTO-SAS study. ESC Heart Fail 2021;8:2513-26.
Nassif ME, Kosiborod M. Effects of sodium glucose cotransporter type 2 inhibitors on heart failure. Diabetes Obes Metab 2019;21:s19-23.
Sawada K, Karashima S, Kometani M, et al. Effect of sodium glucose cotransporter 2 inhibitors on obstructive sleep apnea in patients with type 2 diabetes. Endocr J 2018;65:461-7.
Yeghiazarians Y, Jneid H, Tietjens JR, et al. Obstructive sleep apnea and cardiovascular disease: a scientific statement from the American Heart Association. Circulation 2021;144:e56-e67. Erratum in: Circulation 2022;145:e775.
Lombardi C, Pengo MF, Parati G. Obstructive sleep apnea syndrome and autonomic dysfunction. Auton Neurosci 2019;221:102563.
Cowie MR, Linz D, Redline S, et al. Sleep disordered breathing and cardiovascular disease: JACC state-of-the-art review. J Am Coll Cardiol 2021;78:608-24.
Verbrugge FH, Omote K, Reddy YNV, et al. Heart failure with preserved ejection fraction in patients with normal natriuretic peptide levels is associated with increased morbidity and mortality. Eur Heart J 2022;43:1941-51.
Tamisier R, Pépin JL, Woehrle H, et al. Effect of adaptive servo-ventilation for central sleep apnoea in systolic heart failure on muscle sympathetic nerve activity: a SERVE-HF randomised ancillary study. Eur Respir J 2023;61:2200384.
Bradley TD, Floras JS. Sleep apnea and heart failure: part II: central sleep apnea. Circulation 2003;107:1822-6.
Neeland IJ, Eliasson B, Kasai T, et al. The impact of empagliflozin on obstructive sleep apnea and cardiovascular and renal outcomes: an exploratory analysis of the EMPA-REG OUTCOME trial. Diabetes Care 2020;43:3007-15.
Tang Y, Sun Q, Bai XY, et al. Effect of dapagliflozin on obstructive sleep apnea in patients with type 2 diabetes: a preliminary study. Nutr Diabetes 2019;9:32.
Furukawa S, Miyake T, Senba H, et al. The effectiveness of dapagliflozin for sleep-disordered breathing among Japanese patients with obesity and type 2 diabetes mellitus. Endocr J 2018;65:953-61.
Wojeck BS, Inzucchi SE, Neeland IJ, et al. Ertugliflozin and incident obstructive sleep apnea: an analysis from the VERTIS CV trial. Sleep Breath 2023;27:669-72.
Obokata M, Reddy YNV, Pislaru SV, et al. Evidence supporting the existence of a distinct obese phenotype of heart failure with preserved ejection fraction. Circulation 2017;136:6-19.
Zelniker TA, Braunwald E. Mechanisms of cardiorenal effects of sodium-glucose cotransporter 2 inhibitors: JACC state-of-the-art review. J Am Coll Cardiol 2020;75:422-34. Erratum in: J Am Coll Cardiol 2020;76:1505.
Sano M, Goto S. Possible mechanism of hematocrit elevation by sodium glucose cotransporter 2 inhibitors and associated beneficial renal and cardiovascular effects. Circulation 2019;139:1985-7.
Ekanayake P, Mudaliar S. Increase in hematocrit with SGLT-2 inhibitors - hemoconcentration from diuresis or increased erythropoiesis after amelioration of hypoxia?. Diabetes Metab Syndr 2022;17:102702.
Monda VM, Gentile S, Porcellati F, et al. Heart failure with preserved ejection fraction and obstructive sleep apnea: a novel paradigm for additional cardiovascular benefit of SGLT2 inhibitors in subjects with or without type 2 diabetes. Adv Ther 2022;39:4837-46.
Ethics Approval
This study was approved by the Institutional Ethics Committee.How to Cite
Cacciapuoti, Fulvio, Antonio D’Onofrio, Luca Gaetano Tarquinio, Valentina Capone, Ciro Mauro, Raffaele Marfella, and Federico Cacciapuoti. 2023. “Sleep-Disordered Breathing and Heart Failure: A Vicious Cycle of Cardiovascular Risk”. Monaldi Archives for Chest Disease 94 (2). https://doi.org/10.4081/monaldi.2023.2660.
Copyright (c) 2023 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Gianluigi Balestroni, Giovanna Omarini, Pierangela Omarini, Massimo Pistono, Ugo Corrà , Marco Gnemmi, Pantaleo Giannuzzi, Left ventricular assist device: which emotional impact on the patient? , Monaldi Archives for Chest Disease: Vol. 82 No. 2 (2014): Cardiac series
- Michele Correale, Antonio Totaro, Armando Ferraretti, Matteo Di Biase, Natale Daniele Brunetti, Sildenafil improves clinical and functional status of an elderly postmenopausal female with ‘out of proportion’ PH associated with left heart disease , Monaldi Archives for Chest Disease: Vol. 80 No. 4 (2013): Cardiac Series
- Luigi Maresca, Mariantonietta D’Agostino, Luigi Castaldo, Alessandra Vitelli, Maria Mancini, Giorgio Torella, Rosa Lucci, Giovanna Albano, Domenico Del Forno, Matteo Ferro, Vincenzo Altieri, Francesco Giallauria, Carlo Vigorito, Exercise training improves erectile dysfunction (ED) in patients with metabolic syndrome on phosphodiesterase-5 (PDE-5) inhibitors , Monaldi Archives for Chest Disease: Vol. 80 No. 4 (2013): Cardiac Series
- Rodolfo Citro, Angelo Silverio, Roberto Ascoli, Antonio Longobardi, Eduardo Bossone, Giuseppe Di Benedetto, Federico Piscione, Anterior mitral valve aneurysm perforation in a patient with preexisting aortic regurgitation , Monaldi Archives for Chest Disease: Vol. 78 No. 4 (2012): Cardiac series
- Ahmed Ghanaym, Khaled Elkhashab, Gomaa AbdelRazek, Eman Mahmoud, Evaluation of left atrial dysfunction by speckle tracking echocardiography in systolic and diastolic heart failure , Monaldi Archives for Chest Disease: Vol. 92 No. 4 (2022)
- Edoardo Sciatti, Enrico Vizzardi, Dario S. Cani, Assunta Castiello, Ivano Bonadei, Daria Savoldi, Marco Metra, Antonio D'Aloia, Kounis syndrome, a disease to know: Case report and review of the literature , Monaldi Archives for Chest Disease: Vol. 88 No. 1 (2018)
- E. Westerdahl, M. Fagevik Olsén, Chest physiotherapy and breathing exercises for cardiac surgery patients in Sweden - A National survey of practice , Monaldi Archives for Chest Disease: Vol. 75 No. 2 (2011): Pulmonary series
- Ganesh Narwade, Manu Madan, Rohit Kumar, Pranav Ish, AJ Mahendran, Rajnish Kaushik, Nitesh Gupta, Clinical characteristics of non-sleepy obstructive sleep apnea patients: a study in a tertiary care sleep clinic in India , Monaldi Archives for Chest Disease: Early Access
- Debasis Behera, J C Suri, Pranav Ish, Ruchi Rekha Behera, Shibdas Chakrabarti, Viswesvaran Balasubramanian, Role of esophageal manometry in polysomnography of patients with chronic respiratory failure , Monaldi Archives for Chest Disease: Vol. 91 No. 4 (2021)
- Riccardo Raddino, Ivano Bonadei, Melissa Teli, Federica Chieppa, Giorgio Caretta, Debora Robba, Gregoriana Zanini, Enrico Vizzardi, Livio Dei Cas, Peripartum Cardiomyopathy , Monaldi Archives for Chest Disease: Vol. 70 No. 1 (2008): Cardiac series
<< < 1 2 3 4 5 6 7 8 9 10 > >>
You may also start an advanced similarity search for this article.
