https://doi.org/10.4081/monaldi.2023.2665
Pleural effusion and Waldenström macroglobulinemia: if cytology and flow cytometric findings do not match. A case report
Submitted: June 17, 2023
Accepted: August 28, 2023
Published: September 12, 2023
Accepted: August 28, 2023
Abstract Views: 602
PDF: 96
Publisher's note
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Pleural effusion is a rare complication of lymphoplasmacytic lymphoma. When it occurs, traditional investigation techniques may not always be successful. Flow cytometry is a fast and precise diagnostic technique that can be helpful in the diagnosis of pleural localization of hematological diseases. We present a case report of pleural localization of Waldenström macroglobulinemia detected by flow cytometry.
Gertz MA. Waldenström macroglobulinemia: 2019 update on diagnosis, risk stratification, and management, Am J Hematol 2019;94:266-76.
Banwait R, Aljawai Y, Cappuccio J, et al. Extramedullary Waldenström macroglobulinemia. Am J Hematol 2015;90:100-4.
Gustine JN, Meid K, Hunter ZR, et al. MYD88 mutations can be used to identify malignant pleural effusions in Waldenström macroglobulinaemia. Br J Haematol 2018;180:578-81.
Mansoor A, Wagner RP, DePalma L. Waldenstrom macroglobulinemia presenting as a pleural effusion. Arch Pathol Lab Med 2000;124:891-3.
Arora P, Gupta SK, Mallik N, et al. Flow cytometry in diagnosis of myelomatous pleural effusion: a case report. Indian J Hematol Blood Transfus 2016;32:S138-42.
Chen H, Li P, Xie Y, et al. Cytology and clinical features of myelomatous pleural effusion: Three case reports and a review of the literature. Diagn Cytopathol 2018;46:604-9.
Herold NC, Mitra P. Immunophenotyping. Treasure Island: StatPearls Publishing; 2023.
Keklik M, Sivgin S, Pala C, et al. Flow cytometry method as a diagnostic tool for pleural fluid involvement in a patient with multiple myeloma. Mediterr J Hematol Infect Dis 2012;4:e2012063.
How to Cite
Stirpe, Emanuele, Floriana Bardaro, and Johanna Köhl. 2023. “Pleural Effusion and Waldenström Macroglobulinemia: If Cytology and Flow Cytometric Findings Do Not Match. A Case Report”. Monaldi Archives for Chest Disease 94 (3). https://doi.org/10.4081/monaldi.2023.2665.
Copyright (c) 2023 The Author(s)
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