Anabolic/Catabolic Imbalance in Chronic Heart Failure

Submitted: December 23, 2015
Accepted: December 23, 2015
Published: December 23, 2015
Abstract Views: 844
PDF: 532
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A metabolic imbalance between anabolic drive and catabolic forces is commonly observed in chronic heart failure (CHF) patients, with the latter prevailing over anabolic hormones. Moreover, anabolic deficiencies are independent markers of poor prognosis. This finding represents a solid background for the implementation of therapeutic trials based on replacement therapy. The somatotropic axis (GH/IGF-1) is the most powerful anabolic axis of the body and its decline is related with a poor outcome and a worse clinical status. Growth hormone (GH) administration may enter the therapeutic arena as adjunctive treatment in patients affected by CHF and GH/IGF-1 deficiency. The T.O.S.CA. project aims at investigating the relationship between CHF and hormonal deficiency.

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Cittadini, Antonio, Eduardo Bossone, Alberto Maria Marra, Michele Arcopinto, Emanuele Bobbio, Salvatore Longobardi, Carmine Cevara, Sara Di Michele, and Luigi Saccà. 2015. “Anabolic/Catabolic/Imbalance/in/Chronic/Heart/Failure”. Monaldi Archives for Chest Disease 74 (2). https://doi.org/10.4081/monaldi.2010.266.

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