https://doi.org/10.4081/monaldi.2023.2675
Tako-Tsubo syndrome in patients with COVID-19: a single-center retrospective case series
Submitted: June 29, 2023
Accepted: August 2, 2023
Published: September 5, 2023
Accepted: August 2, 2023
Abstract Views: 660
PDF: 84
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Growing evidence shows that COVID-19 is associated with an increase in Tako-Tsubo syndrome (TTS) incidence. We collected data from patients hospitalized in our multidisciplinary COVID-19 department who had a diagnosis of TTS during the second and third waves of the pandemic in Italy. We reported four cases of TTS associated with COVID-19. Except for COVID-19, no patient had any classical TTS triggers. The mean age was 72 years (67-81) and all patients had COVID-19-related interstitial pneumonia confirmed by computed tomography. Typical apical ballooning and transitory reduction in left ventricle (LV) systolic function with a complete recovery before discharge were observed in all patients. The mean LV ejection fraction at TTS onset was 42% (40-48%). The electrocardiogram showed ST-segment elevation in two cases, while an evolution with negative T waves and corrected QT prolongation was observed in all patients. Three patients underwent coronary angiography. Two patients had Alzheimer’s disease. The time interval from hospital admission to TTS onset was 4 (2-6) days, and the time interval from COVID-19 symptom onset to TTS diagnosis was 10 (8-12) days. COVID-19 may be a trigger for TTS, though TTS pathophysiology in COVID-19 patients remains unclear, likely due to its multifactorial nature.
World Health Organization. Coronavirus 2019 (COVID 19) situation report. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/situation-reports.
Kwenandar F, Japar KV, Damay V, et al. Coronavirus disease 2019 and cardiovascular system: A narrative review. Int J Cardiol Heart Vasc 2020;29:100557.
Nishiga M, Wang DW, Han Y, et al. COVID-19 and cardiovascular disease: from basic mechanisms to clinical perspectives. Nat Rev Cardiol 2020;17:543-58.
Singh S, Desai R, Gandhi Z, et al. Takotsubo syndrome in patients with COVID-19: a systematic review of published cases. SN Compr Clin Med 2020;2:2102-8.
Finsterer J, Stöllberger C. SARS-CoV-2 triggered Takotsubo in 38 patients. J Med Virol 2021;93:1236-8.
Lyon AR, Citro R, Schneider B, et al. Pathophysiology of Takotsubo syndrome: JACC state-of-the-art review. J Am Coll Cardiol 2021;77:902-21.
Ghadri JR, Wittstein IS, Prasad A, et al. International expert consensus document on Takotsubo syndrome (Part I): clinical characteristics, diagnostic criteria, and pathophysiology. Eur Heart J 2018;39:2032-46.
Di Vece D, Citro R, Cammann VL, et al. Outcomes associated with cardiogenic shock in Takotsubo syndrome. Circulation 2019;139:413-5.
Gili S, Cammann VL, Schlossbauer SA, et al. Cardiac arrest in takotsubo syndrome: results from the InterTAK Registry. Eur Heart J 2019;40:2142-51.
Abe Y, Kondo M, Matsuoka R, et al. Assessment of clinical features in transient left ventricular apical ballooning. J Am Coll Cardiol 2003;41:737-42.
Scantlebury DC, Prasad A. Diagnosis of takotsubo cardiomyopathy. Circ J 2014;78:2129-39.
Thygesen K, Alpert JS, Jaffe AS, et al. Fourth universal definition of myocardial infarction (2018). Eur Heart J 2019;40:237-69.
Zuin M, Mugnai G, Anselmi M, et al. Takotsubo syndrome during COVID-19 pandemic in the Veneto Region, Italy. Viruses 2022;14:1971.
Jabri A, Kalra A, Kumar A, et al. Incidence of stress cardiomyopathy during the coronavirus disease 2019 pandemic. JAMA Netw Open 2020;3:e2014780.
Secco GG, Tarantini G, Mazzarotto P, et al. Invasive strategy for COVID patients presenting with acute coronary syndrome: the first multicenter Italian experience. Catheter Cardiovasc Interv 2021;97:195-8.
Dweck MR, Bularga A, Hahn RT, et al. Global evaluation of echocardiography in patients with COVID-19. Eur Heart J Cardiovasc Imaging 2020;21:949-58.
Giustino G, Croft LB, Oates CP, et al. Takotsubo cardiomyopathy in COVID-19. J Am Coll Cardiol 2020;76:628-9.
Arroyo-Rodríguez C, Victoria-Nandayapa JR, López-Aceves M, et al. Takotsubo syndrome in COVID-19: a case series study. Echocardiography 2022;39:920-34.
Techasatian W, Nishimura Y, Nagamine, et al. Characteristics of Takotsubo cardiomyopathy in patients with COVID-19: systematic scoping review. Am Heart J Plus 2022;13:100092.
Zuin M, Dal Santo P, Picariello C, et al. Takotsubo cardiomyopathy in an elderly woman with Alzheimer’s disease: a rare association. Case Report and mini-review of the literature. J Am Geriatr Soc 2016;64:916-7.
Ito M, Fukui K, Miyamoto N, et al. Takotsubo cardiomyopathy in a bedridden patient with dementia and communication difficulties due to Alzheimer’s disease. J Rural Med 2022;17:89-93.
Fajgenbaum DC, June CH. Cytokine storm. N Engl J Med 2020;383:2255-73.
Staedtke V Papadopoulos N, Kinzler KW, et al. Disruption of a self-amplifying catecholamine loop reduces cytokine release syndrome. Nature 2018;564:273-7.
Babapoor-Farrokhran S, Gill D, Walker J, et al. Myocardial injury and COVID-19: possible mechanisms. Life Sci 2020;253:117723.
Dai K, Shiode N, Nakano Y. Disaster-related Takotsubo syndrome - a lesson from the great East Japan earthquake and tsunami on March 11, 2011. Circ J 2021;85:1840-1.
Sato M, Fujita S, Saito A, et al. Increased incidence of transient left ventricular apical ballooning (so-called ‘Takotsubo’ cardiomyopathy) after the mid-Niigata Prefecture earthquake. Circ J 2006;70:947-53.
Meyer P, Degrauwe S, Van Delden C, et al. Typical takotsubo syndrome triggered by SARS-CoV-2 infection. Eur Heart J 2020;41:1860.
Brooks SK, Webster RK, Smith LE, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet 2020;395:912-20.
Salari N, Hosseinian-Far A, Jalali R, et al. Prevalence of stress, anxiety, depression among the general population during the COVID-19 pandemic: a systematic review and meta-analysis. Global Health 2020;16:57.
Okura H. Update of takotsubo syndrome in the era of COVID-19. J Cardiol 2021;77:361-9.
Yin J, Wang S, Liu Y, et al. Coronary microvascular dysfunction pathophysiology in COVID-19. Microcirculation 2021;28:e12718.
Cenko E, Badimon L, Bugiardini R, et al. Cardiovascular disease and COVID-19: a consensus paper from the ESC working group on coronary pathophysiology & microcirculation, ESC working group on thrombosis and the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Heart Rhythm Association (EHRA). Cardiovasc Res 2021;117:2705-29.
How to Cite
Alonzo, Alessandro, Stefania Angela Di Fusco, Lorenzo Castello, Andrea Matteucci, Antonella Spinelli, Gaetano Marino, Stefano Aquilani, Giuseppe Imperoli, and Furio Colivicchi. 2023. “Tako-Tsubo Syndrome in Patients With COVID-19: A Single-Center Retrospective Case Series”. Monaldi Archives for Chest Disease 94 (2). https://doi.org/10.4081/monaldi.2023.2675.
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