https://doi.org/10.4081/monaldi.2024.2685
Evaluation of the effectiveness of Tadalafil on improving pulmonary function and asthma severity in severe asthmatic patients: a randomized controlled trial study
Submitted: June 27, 2023
Accepted: November 21, 2023
Published: January 11, 2024
Accepted: November 21, 2023
Abstract Views: 631
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
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Phosphodiesterase inhibitors elevate the levels of cyclic adenosine monophosphate and cyclic guanosine monophosphate, which have been associated with various anti-inflammatory effects that can help alleviate asthma symptoms. This study aims to assess the impact of Tadalafil, a selective phosphodiesterase inhibitor, on pulmonary function in patients with asthma. This study was a randomized, double-blind clinical trial conducted in 2021 at Imam Khomeini Hospital in Ahvaz, Iran. The study enrolled 44 patients with severe asthma, who were divided equally into a Tadalafil group and a placebo group. The Tadalafil group received 20 mg/day of Tadalafil, while the placebo group received a placebo at the same dose. The patients' spirometry tests, asthma quality of life questionnaire, 6-minute walk distance, and quality of life were measured at the beginning of the study and one month later. The study results indicated that there was no statistically significant difference between the Tadalafil group and the placebo group in terms of pulmonary parameters (p>0.05). Furthermore, the scores for patients' quality of life (p=0.167) and the 6-minute walk test (p=0.148) at the end of the study did not show any statistically significant improvement compared to the placebo group. Results showed that the use of Tadalafil (20 mg) once daily for one month in patients with severe asthma did not affect clinical and laboratory outcomes.
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Ethics Approval
This study was approved by the Medical Ethics Committee of Ahvaz Jundishapur University of Medical Sciences (Ethics code IR.AJUMS.REC.1398.920).How to Cite
Borsi, Seyed Hamid, Seyed Ali Asghar Fakhr Mousavi Fakhr Mousavi, Mehrdad Dargahi Mal-Amir, Heshmatollah Tavakol, and Hanieh Raji. 2024. “Evaluation of the Effectiveness of Tadalafil on Improving Pulmonary Function and Asthma Severity in Severe Asthmatic Patients: A Randomized Controlled Trial Study”. Monaldi Archives for Chest Disease, January. https://doi.org/10.4081/monaldi.2024.2685.
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