Probe-based confocal laser endomicroscopy in the diagnosis of diffuse cystic lung disease in Sjögren’s syndrome

Submitted: July 4, 2023
Accepted: August 28, 2023
Published: September 7, 2023
Abstract Views: 527
PDF: 58
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Authors

Sjögren’s syndrome is a systemic autoimmune disease characterized by lymphocytic infiltration of various organs with a wide frequency of pulmonary involvement. Diffuse cystic lung disease in Sjögren’s syndrome is a rare condition and requires differential diagnosis with other cystic pathologies such as lymphangioleyomiomatosis or Langerhans cell histiocytosis. Probe-based confocal laser endomicroscopy (pCLE) is a method of in vivo investigation of airways and lung tissue at a microscopic level during bronchoscopy. We used this method in diffuse cystic lung disease caused by Sjögren’s syndrome. The pCLE image showed a large number of fluorescent cells, presumably lymphocytes, in bronchioles, dilated alveolar spaces with fluid, and thin alveolar walls. We think that the presence of the bronchiolar cell pattern can be used to differentiate between the pulmonary manifestations of Sjögren’s disease and other cystic lung diseases.

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Citations

Martínez-Balzano CD, Touray S, Kopec S, Cystic lung disease among patients with Sjögren’s syndrome: frequency, natural history and associated risk factors. Chest 2016;150:631-9.
Jagirdar J, Chikkamuniyappa S, Sirohi D, et al. Cystic lung lesions in Sjogren syndrome: analysis of lymphocyte subsets in tissue with clinico-radiologic-pathologic correlation. Ann Diagn Pathol 2013;17:113-6.
Gupta N, Wikenheiser-Brokamp KA, Fischer A, McCormack FX. Diffuse cystic lung disease as the presenting manifestation of Sjögren syndrome. Ann Am Thorac Soc 2016;13:371-5.
González LA, Pantoja-Marquez AE, Johnson P. Diffuse cystic lung disease: consider Sjögren syndrome in the differential diagnosis. Am J Med 2020;133:e438-9.
Flament T, Bigot A, Chaigne B, et al. Pulmonary manifestations of Sjögren’s syndrome. Eur Respir Rev 2016;25:110-23.
Thiberville L, Salaun M, Lachkar S, et al. Human in vivo fluorescence microimaging of the alveolar ducts and sacs during bronchoscopy. Eur Respir J 2009;33:974-85.
Salaün M, Guisier F, Dominique S, et al. In vivo probe-based confocal laser endomicroscopy in chronic interstitial lung. Respirology 2019;24:783-91.
Silbernagel E, Stacher-Priehse E, Dinkel J, et al. Bronchoscopic probe-based confocal laser endomicroscopy to diagnose diffuse parenchymal lung diseases. Sarcoidosis Vasc Diffuse Lung Dis 2022;39:e2022016.
Papiris SA, Maniati M, Constantopoulos SH, et al. Lung involvement in primary Sjögren’s syndrome is mainly related to the small airway disease. Ann Rheum Dis 1999;58:61-4.
Kobayashi H, Matsuoka R, Kitamura S, et al. Sjögren’s syndrome with multiple bullae and pulmonary nodular amyloidosis. Chest 1988;94:438-40.
Yserbyt J, Dooms C, Ninane V, et al. Perspectives using probe-based confocal laser endomicroscopy of the respiratory tract. Swiss Med Wkly 2013;143:w13764.

Ethics Approval

The use of probe-based confocal laser endomicroscopy was approved by the local Ethical Committee.

How to Cite

Mamenko, Igor Sergeevich, Igor V. Vasilev, Roman V. Simonov, Anna S. Zakharova, Pavel V. Gavrilov, Ivetta V. Dvorakovskaya, Tatiana A. Novitskaya, and Petr K. Yablonskiy. 2023. “Probe-Based Confocal Laser Endomicroscopy in the Diagnosis of Diffuse Cystic Lung Disease in Sjögren’s Syndrome”. Monaldi Archives for Chest Disease 94 (3). https://doi.org/10.4081/monaldi.2023.2699.

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