https://doi.org/10.4081/monaldi.2023.2706
Monocyte-related hematological indices in acute exacerbations of chronic obstructive pulmonary disease – a new biomarker?
Submitted: July 8, 2023
Accepted: September 14, 2023
Published: September 25, 2023
Accepted: September 14, 2023
Abstract Views: 873
PDF: 49
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
C-reactive protein (CRP) and leukocyte count are standard tools for recognizing inflammation in chronic obstructive pulmonary disease (COPD) patients. This study aimed to find out whether there is a pattern in monocyte-related hematological indices [monocyte to neutrophil ratio (MNR) and monocyte to lymphocyte ratio (MLR)], which could help differentiate COPD patients in need of hospitalization due to acute exacerbation of COPD and distinguish frequent COPD exacerbators from non-frequent COPD exacerbators. The study included 119 COPD patients and 35 control subjects, recruited at the Clinic for Respiratory Diseases Jordanovac, University Hospital Centre Zagreb, Croatia. A complete blood count was performed on Sysmex XN-1000, CRP on Cobas c501, and fibrinogen on the BCS XP analyzer. Data were analyzed with MedCalc statistical software. The COPD patients were divided into three groups: frequent exacerbators (FE), non-frequent exacerbators (NFE), and patients hospitalized for acute COPD exacerbations (HAE), and the control group consisted of healthy smokers (HS). A statistically significant difference was found in the values of MNR while comparing these groups of patients: FE vs. HAE (p<0.000), NFE vs. HAE (p<0.000), and HS vs. HAE (p<0.001); and for the values of MLR: FE vs. HAE (p<0.022), NFE vs. HAE (p<0.000), and HS vs. HAE (p<0.000). As MLR and MNR have shown the statistical difference comparing the group of HAE to NFE, FE, and HS, MLR and MNR could be valuable and available markers of acute COPD exacerbations and the need for hospitalization.
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Ethics Approval
The Ethics Committee of University Hospital Centre Zagreb and University of Zagreb School of Medicine (Zagreb, Croatia) approved the study in January 2013.How to Cite
Dukić, Višnja, Davorka Muršić, Sanja Popović Grle, Marko Jakopović, Alen Ružić, and Andrea Vukić Dugac. 2023. “Monocyte-Related Hematological Indices in Acute Exacerbations of Chronic Obstructive Pulmonary Disease – a New Biomarker?”. Monaldi Archives for Chest Disease 94 (3). https://doi.org/10.4081/monaldi.2023.2706.
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