https://doi.org/10.4081/monaldi.2023.2706
Monocyte-related hematological indices in acute exacerbations of chronic obstructive pulmonary disease – a new biomarker?
Submitted: July 8, 2023
Accepted: September 14, 2023
Published: September 25, 2023
Accepted: September 14, 2023
Abstract Views: 873
PDF: 49
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
C-reactive protein (CRP) and leukocyte count are standard tools for recognizing inflammation in chronic obstructive pulmonary disease (COPD) patients. This study aimed to find out whether there is a pattern in monocyte-related hematological indices [monocyte to neutrophil ratio (MNR) and monocyte to lymphocyte ratio (MLR)], which could help differentiate COPD patients in need of hospitalization due to acute exacerbation of COPD and distinguish frequent COPD exacerbators from non-frequent COPD exacerbators. The study included 119 COPD patients and 35 control subjects, recruited at the Clinic for Respiratory Diseases Jordanovac, University Hospital Centre Zagreb, Croatia. A complete blood count was performed on Sysmex XN-1000, CRP on Cobas c501, and fibrinogen on the BCS XP analyzer. Data were analyzed with MedCalc statistical software. The COPD patients were divided into three groups: frequent exacerbators (FE), non-frequent exacerbators (NFE), and patients hospitalized for acute COPD exacerbations (HAE), and the control group consisted of healthy smokers (HS). A statistically significant difference was found in the values of MNR while comparing these groups of patients: FE vs. HAE (p<0.000), NFE vs. HAE (p<0.000), and HS vs. HAE (p<0.001); and for the values of MLR: FE vs. HAE (p<0.022), NFE vs. HAE (p<0.000), and HS vs. HAE (p<0.000). As MLR and MNR have shown the statistical difference comparing the group of HAE to NFE, FE, and HS, MLR and MNR could be valuable and available markers of acute COPD exacerbations and the need for hospitalization.
GOLD. Global strategy for the diagnosis, management and prevention of copd. global initiative for chronic obstructive lung disease. 2018 report. Available from: https://goldcopd.org/wp-content/uploads/2017/11/GOLD-2018-v6.0-FINAL-revised-20-Nov_WMS.pdf
GBD 2016 Causes of Death Collaborators. Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016. Lancet 2017;390:1151-10.
Global Health Epidemiology Reference Group (GHERG). Global and regional estimates of COPD prevalence: Systematic review and meta-analysis. J Glob Health 2015;5:020415.
Miravitlles M, Soler-Cataluña JJ, Calle M, et al. A new approach to grading and treating COPD based on clinical phenotypes: summary of the Spanish COPD guidelines (GesEPOC). Prim Care Respir J 2013;22:117-21.
Halpin DM, Decramer M, Celli B, et al. Exacerbation frequency and course of COPD. Int J Chron Obstruct Pulmon Dis 2012;7:653-61.
Hurst JR, Vestbo J, Anzueto A, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med 2010;363:1128-38.
Soler-Cataluña JJ, Martínez-García MA, Sánchez PR, et al. Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease. Thorax 2005;60:925-31.
Connors AF, Dawson NV, Thomas C, et al. Outcomes following acute exacerbation of severe chronic obstructive lung disease. Am J Respir Crit Care Med 1996;154:959-67.
Seneff MG, Wagner DP, Wagner RP, et al. Hospital and 1-year survival of patients admitted to intensive care units with acute exacerbation of chronic obstructive pulmonary disease. JAMA 1995;274:1852-7.
Halpin DMG, Decramer M, Celli B, et al. Effect of a single exacerbation on decline in lung function in COPD. Res Med 2017;128:85-91.
Thomsen M, Truls SI, Marott JL, et al. Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease. JAMA 2013;309:2353-61.
Zemans RL, Jacobson S, Keene J, et al. Multiple biomarkers predict disease severity, progression and mortality in COPD. Respir Res 2017;18:117.
Huang Z, Fu Z, Huang W, et al. Prognostic value of neutrophil-to-lymphocyte ratio in sepsis: a meta-analysis. Am J Emerg Med 2020;38:641-7.
Templeton AJ, McNamara MG, Šeruga B, et al. Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis. J Natl Cancer Inst 2014;106:dju124.
Hlapčić I, Somborac-Bačura A, Popović-Grle S, et al. Platelet indices in stable chronic obstructive pulmonary disease – association with inflammatory markers, comorbidities and therapy. Biochem Med (Zagreb) 2020;30:010701.
Paliogiannis P, Fois AG, Sotgia S, et al. Neutrophil to lymphocite ratio and clinical outcomes in COPD: recent evidence and future perspectives. Eur Res Review 2018;27:170113.
Aksoy E, Karakurt Z, Gungor S, et al. Neutrophil to lymphocyte ratio is a better indicator of COPD exacerbation severity in neutrophilic endotypes than eosinophilic endotypes. Int J Chron Obstruct Pulmon Dis 2018;13:2721-30.
Tan D, Fu Y, Tong W, et al. Prognostic significance of lymphocyte to monocyte ratio in colorectal cancer: a meta-analysis. Int J Surg 2018;55;128-38.
Mazza MG, Tringali AGM, Rosetti A, et al. Cross-sectional study of neutrophil-lymphocyte, platelet-lymphocyte and monocyte-lymphocyte ratios in mood disorders. Gen Hosp Psychiatry 2019;58:7-12.
Baran O, Kemerdere R, Korkmaz TS, et al. Can preoperative neutrophil to lymphocyte, lymphocyte to monocyte, or platelet to lymphocyte ratios differentiate glioblastoma from brain metastasis? Medicine 2019;98:e18306.
Liu P, Li P, Peng Z, et al. Predictive value of the neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, platelet-to-neutrophil ratio, and neutrophil-to-monocyte ratio in lupus nephritis. Lupus 2020;29:1031-9.
Jeon YL, Lee WI, Kang SY, et al. Neutrophil-to-monocyte-plus-lymphocyte ratio as a potential marker for discriminating pulmonary tuberculosis from nontuberculosis infectious lung diseases. Lab Med 2019;50:286-91.
Rahimirad S, Ghaffary MR, Rahimirad MH, et al. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease. Tuberk Toraks 2017;65:25-31.
Lee JS, Kim NY, Na SH, et al. Reference values of neutrophil-lymphocyte ratio, lymphocyte-monocyte ratio, platelet-lymphocyte ratio, and mean platelet volume in healthy adults in South Korea. Medicine 2018;97:e11138.
Gao K, Zhu W, Liu W, et al. Diagnostic value of the blood monocyte–lymphocyte ratio in knee osteoarthritis. J Int Med Res 2019;47:4413-21.
Perera WR, Hurst JR, Wilkinson TMA, et al. Inflammatory changes, recovery and recurrence at COPD exacerbation. Eur Respir J 2007;29:527-34.
El-Gazzar AG, Kamel MH, Elbahnasy OKM, et al. Prognostic value of platelet and neutrophil to lymphocyte ratio in COPD patients. Expert Rev Respir Med 2020;14:111-6.
Karadeniz G, Aktoğu S, Erer F, et al. Predictive value of platelet-to-lymphocyte ratio in exacerbation of chronic obstructive pulmonary disease. Biomark Med 2016;10:701-10.
Ethics Approval
The Ethics Committee of University Hospital Centre Zagreb and University of Zagreb School of Medicine (Zagreb, Croatia) approved the study in January 2013.How to Cite
Dukić, Višnja, Davorka Muršić, Sanja Popović Grle, Marko Jakopović, Alen Ružić, and Andrea Vukić Dugac. 2023. “Monocyte-Related Hematological Indices in Acute Exacerbations of Chronic Obstructive Pulmonary Disease – a New Biomarker?”. Monaldi Archives for Chest Disease 94 (3). https://doi.org/10.4081/monaldi.2023.2706.
Copyright (c) 2023 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Megha Hegde, Saurav Raj, Aishwarya S Pattanshetti, Sanatkumar Bharamu Nyamagoud, Gaining insights into chronic obstructive pulmonary disease exacerbation through emerging biomarkers and the chronic obstructive pulmonary disease assessment test score , Monaldi Archives for Chest Disease: Early Access
- Manju Bala, Akhlesh Rajpoot, Dinesh Chandra Punera, Suyash Singh Rathore, Hormonal harmony disrupted: hypothyroidism and diabetes mellitus in interstitial lung disease. An observational study , Monaldi Archives for Chest Disease: Early Access
- Yaser Jenab, Marzieh Pourjafari, Maryam Sotoudeh, Masoumeh Lotfi-tokaldany, Nasrin Etesamifard, Shapour Shirani, Arash Jalali, Younes Nozari, Hamid-reza Poorhosseini, Comparing the effect of cardiac biomarkers on the outcome of normotensive patients with acute pulmonary embolism , Monaldi Archives for Chest Disease: Vol. 87 No. 1 (2017)
- Sameer Vaidya, Dipti Gothi, Mahismita Patro, COPD sleep phenotypes: Genesis of respiratory failure in COPD , Monaldi Archives for Chest Disease: Vol. 92 No. 2 (2022)
- Vipul Prakash, Arjun Kumar, Lokesh Kumar Saini, Barun Kumar, Girish Sindhwani, Prakhar Sharma, Ruchi Dua, Ravi Gupta, Mayank Mishra, Proportion of sleep-related breathing disorders and their association with echocardiographic parameters in stable patients with chronic obstructive pulmonary disease: a cross-sectional observational exploratory study , Monaldi Archives for Chest Disease: Early Access
- E.F. Porto, A.A.M. Castro, M. Velloso, O. Nascimento, F. Dal Maso, J.R. Jardim, Exercises using the upper limbs hyperinflate COPD patients more than exercises using the lower limbs at the same metabolic demand , Monaldi Archives for Chest Disease: Vol. 71 No. 1 (2009): Pulmonary series
- M. Malerba, G. Romanelli, Early cardiovascular involvement in Chronic Obstructive Pulmonary Disease , Monaldi Archives for Chest Disease: Vol. 71 No. 2 (2009): Pulmonary series
- Iqbal Akhtar Khan, Paola Pierucci, Nicolino Ambrosino, COPD patients’ pre-flight check: A narrative review , Monaldi Archives for Chest Disease: Vol. 92 No. 4 (2022)
- Martina Vigorè, Nicolo Granata, Giovanna Callegari, Raffaella Vaninetti, Simona Conti, Roberto Maestri, Giancarlo Piaggi, Gioele Cremonese, Antonia Pierobon, Frailty and rehabilitation outcome in older patients with cardiorespiratory disease: preliminary multidimensional data , Monaldi Archives for Chest Disease: Vol. 93 No. 4 (2023)
- Soumaya Benmaamar, Btissame Es-sabbahi, Mohammed Taghyioullah Haiba, Mohamed Omari, Ibtissam El Harch, Mohammed Youbi, Latifa Belakhhel, Loubna Abousselham, Hafid Hachri, Imane El Menchawyi, Samira EL Fakir, Mohammed Chakib Benjelloun, Nabil Tachfouti, Economic burden of chronic obstructive pulmonary disease in Morocco: a cost of illness study , Monaldi Archives for Chest Disease: Early Access
<< < 4 5 6 7 8 9 10 11 12 13 > >>
You may also start an advanced similarity search for this article.
