https://doi.org/10.4081/monaldi.2023.2738
Effects of pulmonary rehabilitation in survivors of severe acute respiratory syndrome coronavirus 2. Role of vaccination
Submitted: August 1, 2023
Accepted: September 11, 2023
Published: September 18, 2023
Accepted: September 11, 2023
Abstract Views: 493
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Survivors of severe COVID-19 requiring hospital admission may suffer from short- and long-term sequelae, including disability and reduced physical performance. Vaccination and pulmonary rehabilitation (PR) are effective tools against COVID-19 effects. While the beneficial effect of each of these treatments is known, there are no data about their combined effect. In people admitted to PR hospitals after severe COVID-19 disease, we retrospectively analyzed whether PR outcome might be influenced by vaccination status. Ninety-six individuals were studied (46 vaccinated, 50 unvaccinated). Unvaccinated individuals were younger and less comorbid than vaccinated ones and had needed more intensive care support during the previous hospitalization. Measures of disability and physical performance did not differ between groups at the beginning and at the end of the PR program. However, each group showed a statistically significant improvement in all outcome measures (6-minute walking test, short physical performance battery, Barthel Index). We conclude that vaccination status does not influence the outcome of in-patient PR programs for survivors of severe COVID-19.
Johns Hopkins University [Internet]. COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins University (JHU). Accessed April 14, 2023. Available from: https://coronavirus.jhu.edu/map.html
Attaway AH, Scheraga RG, Bhimraj A, et al. Severe covid-19 pneumonia: phatogenesis and clinical management. BMJ 2021;327:n436.
DOI: https://doi.org/10.1136/bmj.n436
Tenforde MW, Self WH, Adams K, et al. Association between mRNA vaccination and COVID-19 hospitalization and disease severity. JAMA 2021;326:2043-54.
DOI: https://doi.org/10.1001/jama.2021.19499
Torres-Castro R, Vasconcello-Castillo L, Alsina-Restoy X, et al. Respiratory function in patients post-infection by COVID-19: a systematic review and meta-analysis. Pulmonology 2021;27:328-37.
DOI: https://doi.org/10.1016/j.pulmoe.2020.10.013
Paneroni M, Simonelli C, Saleri M, et al. Muscle strength and physical performance in patients without previous disabilities recovering from COVID-19 pneumonia. Am J Phys Med Rehabil 2021;100:105-9.
DOI: https://doi.org/10.1097/PHM.0000000000001641
Huang C, Huang L, Wang Y, et al. 6-Month consequences of COVID-19 in patients discharged from hospital: a cohort study. Lancet 2021;397:220-32.
DOI: https://doi.org/10.1016/S0140-6736(20)32656-8
Zampogna E, Paneroni M, Belli S, et al. Pulmonary rehabilitation in patients recovering from COVID-19. Respiration 2021;100:416-22.
DOI: https://doi.org/10.1159/000514387
Vitacca M, Migliori GB, Spanevello A, et al. Management and outcomes of post-acute COVID-19 patients in Northern Italy. Eur J Intern Med 2020;78:159-60.
DOI: https://doi.org/10.1016/j.ejim.2020.06.005
Ceriana P, Vitacca M, Paneroni M, et al. Usefulness of step down units to manage survivors of critical Covid-19 patients. Eur J Intern Med 2021;88:126-8.
DOI: https://doi.org/10.1016/j.ejim.2021.03.002
Vitacca M, Malovini A, Spanevello A, et al. Clusters of individuals with chronic obstructive pulmonary disease according to baseline characteristics and response to post exacerbation pulmonary rehabilitation. Pulmonology 2023;29:230-9.
DOI: https://doi.org/10.1016/j.pulmoe.2023.01.002
Linn BS, Linn MW, Gurel L. Cumulative illness rating scale. J Am Geriatr Soc 1968;16:622-6.
DOI: https://doi.org/10.1111/j.1532-5415.1968.tb02103.x
Simonelli C, Paneroni M, Vitacca M, Ambrosino N. Measures of physical performance in COVID-19 patients: a mapping review. Pulmonology 2021;27:518-28.
DOI: https://doi.org/10.1016/j.pulmoe.2021.06.005
Shah S, Vanclay F, Cooper B. Improving the sensitivity of the Barthel index for stroke rehabilitation. J Clin Epidemiol 1989;42:703-9.
DOI: https://doi.org/10.1016/0895-4356(89)90065-6
Holland AE, Spruit MA, Troosters T, et al. An official European Respiratory Society/American Thoracic Society technical standard: field walking test in chronic respiratory disease. Eur Respir J 2014;44:1428-46.
DOI: https://doi.org/10.1183/09031936.00150314
Enright PL, Sherrill D. Reference equations for the six-minute walk in healthy adults. Am J Respir Crit Care Med1998;158:1384-7.
DOI: https://doi.org/10.1164/ajrccm.158.5.9710086
Du Bois RM, Weycker D, Albera C, et al. Six-minute walk test in idiopathic pulmonary fibrosis: test validation and minimal clinically important difference. Am J Respir Crit Care Med 2011;183:1231-7.
DOI: https://doi.org/10.1164/rccm.201007-1179OC
Bernabeu-Mora R, Medina-Mirapeix F, Lamazares-Herran E, et al. The short physical performance battery is a discriminative tool for identifying patients with COPD at risk of disability. Int J Chron Obstruct Pulmon Dis 2015;10:2619-26.
DOI: https://doi.org/10.2147/COPD.S94377
Perera S, Mody SH, Woodman RC, Studenski SA. Meaningful change and responsiveness in common physical performance measures in older adults. J Am Geriatr Soc 2006;54:743-9.
DOI: https://doi.org/10.1111/j.1532-5415.2006.00701.x
Schreiber AF, Ceriana P, Ambrosino N, et al. Physiotherapy and weaning from prolonged mechanical ventilation. Respir Care 2019;64:17-25.
DOI: https://doi.org/10.4187/respcare.06280
Bucchi M, Fattorini E, Saracino B. Public perception of COVID-19 vaccination in Italy: The role of trust and experts' communication. Int J Public Health 2022;67:1604222.
DOI: https://doi.org/10.3389/ijph.2022.1604222
Rania N, Coppola I, Brucci M, Lagomarsino F. Attitudes and beliefs of the Italian population towards COVID-19 vaccinations. Int J Environ Res Public Health 2022;19:6139.
DOI: https://doi.org/10.3390/ijerph19106139
Giuliani M, Ichino A, Bonomi A, et al. Who Is willing to get vaccinated? A study into the psychological, socio-demographic, and cultural determinants of COVID-19 vaccination intentions. Vaccines (Basel) 2021;9:810.
DOI: https://doi.org/10.3390/vaccines9080810
Altobelli E, Marzi F, Angelone AM, et al. Burden of COVID-19 and vaccination coverage in the Italian population as of October 2021. Int J Environ Res Public Health 2022;19:496
DOI: https://doi.org/10.3390/ijerph19010496
Lorenzoni G, Rosi P, De Rosa S, et al. COVID-19 vaccination status among adults admitted to Intensive Care Units in Veneto, Italy. JAMA Netw Open 2022;5:e2213553.
DOI: https://doi.org/10.1001/jamanetworkopen.2022.13553
Whittaker R, Bråthen Kristofferson A, Valcarcel Salamanca B, et al. Length of hospital stay and risk of intensive care admission and in-hospital death among COVID-19 patients in Norway: a register-based cohort study comparing patients fully vaccinated with an mRNA vaccine to unvaccinated patients. Clin Microbiol Infect 2022;28:871-8.
DOI: https://doi.org/10.1016/j.cmi.2022.01.033
Doiron KA, Hoffmann TC, Beller EM. Early intervention (mobilization or active exercise) for critically ill adults in the intensive care unit. Cochrane Database Syst Rev 2018;3(3):CD010754.
DOI: https://doi.org/10.1002/14651858.CD010754.pub2
Puthucheary ZA, Rawal J, McPhail M, P et al. Acute skeletal muscle wasting in critical illness. JAMA 2013;310:1591-600.
DOI: https://doi.org/10.1001/jama.2013.278481
Loyd C, Markland AD, Zhang Y, et al. Prevalence of hospital-associated disability in older adults: A Meta-analysis. J Am Med Dir Assoc 2020;21:455-61.e5.
DOI: https://doi.org/10.1016/j.jamda.2019.09.015
Spruit MA, Augustin IM, Vanfleteren LE, et al. Differential response to pulmonary rehabilitation in COPD: a multidimensional profiling. Eur Respir J 2015;46:1625-35.
DOI: https://doi.org/10.1183/13993003.00350-2015
Duarte-de-Ara Jo AN, Teixeira P, Hespanhol V, Correia-de-Sousa J. COPD: How can evidence from randomised controlled trials apply to patients treated in everyday clinical practice? Pulmonology 2022;28:431-9.
DOI: https://doi.org/10.1016/j.pulmoe.2020.02.003
Ethics Approval
The study was approved by the Istituti Clinici Scientifici (ICS) Maugeri IRCCS Ethics CommitteeHow to Cite
Vigna, Matteo, Piero Ceriana, Mara Santomassimo, Michele Vitacca, Mauro Maniscalco, and Nicolino Ambrosino. 2023. “Effects of Pulmonary Rehabilitation in Survivors of Severe Acute Respiratory Syndrome Coronavirus 2. Role of Vaccination”. Monaldi Archives for Chest Disease, September. https://doi.org/10.4081/monaldi.2023.2738.
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