https://doi.org/10.4081/monaldi.2023.2748

Synchronous lung cancer presenting with small cell carcinoma and squamous cell lung carcinoma: a case report

Vol. 94 No. 3 (2024)
Submitted: August 13, 2023
Accepted: September 20, 2023
Published: September 28, 2023
Small-cell lung carcinoma, squamous cell lung carcinoma, synchronous multiple primary lung cancer
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Authors

Emanuele Stirpe
emanuele.stirpe@sabes.it
https://orcid.org/0000-0001-5062-4733
Department of Respiratory Diseases, Bolzano Hospital, Italy.
Floriana Bardaro
Department of Respiratory Diseases, Bolzano Hospital, Italy.
Johanna Köhl
https://orcid.org/0000-0002-1984-5420
Department of Respiratory Diseases, Bolzano Hospital, Italy.

Synchronous multiple primary lung cancers (SMPLC) are separate tumors presenting at the same time with different histology. We present a rare case of a 64-year-old patient with a combination of small-cell lung carcinoma (SCLC) and squamous carcinoma in two different sites with metastasis of the SCLC in the mediastinal lymph node. The SCLC diagnosis was performed via bronchoscopy, and the other diagnosis via computed tomography-guided transthoracic biopsy. It is often difficult to distinguish a synchronous tumor from intrapulmonary metastases. To date, there are no guidelines for the treatment of these cases. The management of SMPLC, mainly surgical with chemotherapy or radiotherapy, must be studied according to the histological type, staging, and molecular testing of the tumors. These rare cases of SMPLC require individual treatment and a multidisciplinary approach.

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Crossref
Scopus
Google Scholar
Europe PMC
Romaszko AM, Doboszyńska A. Multiple primary lung cancer: a literature review. Adv Clin Exp Med 2018;27:725-30.
Nie Y, Wang X, Yang F, et al. Surgical prognosis of synchronous multiple primary lung cancer: a systematic review and meta-analysis. Clin Lung Cancer 2021;22:341-50.e3.
Martini N, Melamed MR. Multiple primary lung cancers. J Thorac Cardiovasc Surg 1975;70:606-12.
Detterbeck FC, Nicholson AG, Franklin WA, et al. The IASLC lung cancer staging project: summary of proposals for revisions of the classification of lung cancers with multiple pulmonary sites of involvement in the forthcoming eighth edition of the TNM classification. J Thorac Oncol 2016;11:639-50.
Amin MB, Edge S, Green FL, et al. AJCC Cancer Staging Manual. 8th ed. New York, NY, USA: Springer; 2017.
Asamura H. Multiple primary cancers or multiple metastases, that is the question. J Thorac Oncol 2010;5:930-1.
Griffioen GH, Lagerwaard FJ, Haasbeek CJ, et al. Treatment of multiple primary lung cancers using stereotactic radiotherapy, either with or without surgery. Radiother Oncol 2013;107:403-8.
Huimin Z, Xueting W, Qi Q, et al. Multiple primary lung cancers with ALK rearrangement: a case report and literature review. Front Oncol 2022;12:897451.
Trousse D, Barlesi F, Loundou A, et al. Synchronous multiple primary lung cancer: An increasing clinical occurrence requiring multidisciplinary management. J Thorac Cardiovasc Surg 2007;133:1193-200.
Hiraki A, Ueoka H, Yoshino T, et al. Synchronous primary lung cancer presenting with small cell carcinoma and non-small cell carcinoma: diagnosis and treatment. Oncol Rep 1999;6:75-80.
Ghattas C, Hundal M, Agustin M, Unterborn J. A rare type of synchronous multiple primary lung cancer: staging and treat ment dilemma. Am J Resp Crit Care 2016;193:A6125.
Tie H, Luo J, Shi R, et al. Characteristics and prognosis of synchronous multiple primary lung cancer after surgical treatment: a systematic review and meta-analysis of current evidence. Cancer Med 2021;10:507-20.
Jiang L, He J, Shi X, et al. Prognosis of synchronous and metachronous multiple primary lung cancers: systematic review and meta-analysis. Lung Cancer 2015;87:303-10.
Monjazeb AM, Daly ME, Luxardi G, et al. Atezolizumab plus stereotactic ablative radiotherapy for medically inoperable patients with early-stage non-small cell lung cancer: a multi-institutional phase I trial. Nat Commun 2023;14:5332.
Dzian A, Ivan F, Zdenko H, Peter S. Primary synchronous small and non-small cell lung cancer in the same lung lobe: A case report. Monaldi Arch Chest Dis 2017;87:797.
Pezzuto A, Trabalza Marinucci B, Ricci A, et al. Predictors of respiratory failure after thoracic surgery: a retrospective cohort study with comparison between lobar and sub-lobar resection. J Int Med Res 2022;50:3000605221094531.
Tian H, Bai G, Yang Z, et al. Multiple primary lung cancer: updates of clinical management and genomic features. Front Oncol 2023;13:1034752.
Dingemans AC, Früh M, Ardizzoni A, et al. Small-cell lung cancer: ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2021;32:839-53.

How to Cite

Stirpe, Emanuele, Floriana Bardaro, and Johanna Köhl. 2023. “Synchronous Lung Cancer Presenting With Small Cell Carcinoma and Squamous Cell Lung Carcinoma: A Case Report”. Monaldi Archives for Chest Disease 94 (3). https://doi.org/10.4081/monaldi.2023.2748.
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