https://doi.org/10.4081/monaldi.2023.2776
Diabetes mellitus in acute exacerbation of chronic obstructive pulmonary disease – the tip of the iceberg
Submitted: September 11, 2023
Accepted: October 31, 2023
Published: November 6, 2023
Accepted: October 31, 2023
Abstract Views: 666
PDF_early view: 265
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
COPD is a chronic respiratory disease characterized by systemic inflammation caused primarily by tobacco use, and it is associated with an increased susceptibility to respiratory infections, both viral and bacterial, which are responsible for acute COPD exacerbations (AECOPD). Diabetes mellitus is one of the most common co-morbidities in COPD patients. In our study, we attempted to detect previously undiagnosed diabetes in AECOPD patients who presented to our Institute. The study included 100 patients who had been diagnosed with AECOPD. Pearson's coefficient correlation analysis was used to assess the relationship between various parameters. The vast majority of patients belonged to Group 3. (diagnosed at the time of admission as having type II diabetes). HbA1c had a significant positive correlation with BMI, cholesterol, and TLC, but a negative correlation with SpO2. Using HbA1C, nearly two-thirds of the AECOPD were newly diagnosed with diabetes mellitus. Our findings suggest that diabetes is significantly underdiagnosed in COPD patients.
Mathioudakis AG, Vanfleteren LE, Lahousse L, et al. Current developments and future directions in COPD. Eur Respir Rev 2020;29:200289.
DOI: https://doi.org/10.1183/16000617.0289-2020
Singh D, Agusti A, Anzueto A, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease: the GOLD science committee report 2019. Eur Respir J 2019;53:1900164.
DOI: https://doi.org/10.1183/13993003.00164-2019
Buist AS. Risk factors for COPD. Eur Respir Rev 1996;6:253-8.
Hayden LP, Hobbs BD, Cohen RT, et al. Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPD Gene study. Respir Res 2015;16:1-9.
DOI: https://doi.org/10.1186/s12931-015-0273-8
Stone P, Sood N, Feary J, et al. Validation of acute exacerbation of chronic obstructive pulmonary disease (COPD) recording in electronic health records: a systematic review protocol. BMJ Open 2020;10:e032467.
DOI: https://doi.org/10.1136/bmjopen-2019-032467
Cavaillès A, Brinchault-Rabin G, Dixmier A, et al. Comorbidities of COPD. Eur Respir Rev 2013;22:454-75.
DOI: https://doi.org/10.1183/09059180.00008612
Kiani FZ, Ahmadi A. Prevalence of different comorbidities in chronic obstructive pulmonary disease among Shahrekord PERSIAN cohort study in southwest Iran. Sci Rep 2021;11:1548.
DOI: https://doi.org/10.1038/s41598-020-79707-y
Gilstrap LG, Chernew ME, Nguyen CA, et al. Association between clinical practice group adherence to quality measures and adverse outcomes among adult patients with diabetes. JAMA Netw Open 2019;2:e199139.
DOI: https://doi.org/10.1001/jamanetworkopen.2019.9139
Baker EH, Janaway CH, Philips BJ, et al. Hyperglycaemia is associated with poor outcomes in patients admitted to hospital with acute exacerbations of chronic obstructive pulmonary disease. Thorax 2006;61:284-9.
DOI: https://doi.org/10.1136/thx.2005.051029
Chen G, Lin Q, Zhuo D, Cui J. Elevated blood glucose is associated with severe exacerbation of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2022;17:2453-9.
DOI: https://doi.org/10.2147/COPD.S378259
Seo H, Sim YS, Min KH, et al. The relationship between comorbidities and microbiologic findings in patients with acute exacerbation of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis 2022;17:855-67.
DOI: https://doi.org/10.2147/COPD.S360222
Maan HB, Meo SA, Al Rouq F, et al. Effect of glycated hemoglobin (hba1c) and duration of disease on lung functions in type 2 diabetic patients. Int J Environ Res Public Health 2021;18:6970.
DOI: https://doi.org/10.3390/ijerph18136970
Mondal C, Ray A, Kumar A. A study of pulmonary function tests in type 2 diabetes mellitus patients of sub-Himalayan plain area of Darjeeling District. Int J Sci Res 2019;8.
Tai H, Jiang XL, Yao SC, et al. Vascular endothelial function as a valid predictor of variations in pulmonary function in T2DM patients without related complications. Front Endocrinol 2021;12:622768.
DOI: https://doi.org/10.3389/fendo.2021.622768
Gläser S, Krüger S, Merkel M, et al. Chronic obstructive pulmonary disease and diabetes mellitus: a systematic review of the literature. Respiration 2015;89:253-64.
DOI: https://doi.org/10.1159/000369863
Davis WA, Knuiman M, Kendall P, et al. Glycaemic exposure is associated with reduced pulmonary function in type 2 diabetes: the Fremantle Diabetes Study. Diabetes Care 2004;27:752-7.
DOI: https://doi.org/10.2337/diacare.27.3.752
Motamed B, Alavi Foumani A, Tangestaninezhad A, et al. The relationship between glycated hemoglobin A1c levels and exacerbation status in the patients with chronic obstructive pulmonary disease. BMC Res Notes 2022;15:326.
DOI: https://doi.org/10.1186/s13104-022-06217-7
Zhang RH, Zhou JB, Cai YH, et al. Non-linear association between diabetes mellitus and pulmonary function: a population-based study. Respir Res 2020;21:292.
DOI: https://doi.org/10.1186/s12931-020-01538-2
Ethics Approval
This study was approved by Institute Ethics Committee with reference number NITRD/PGEC/2018/6621How to Cite
Tayal, Devika, Prerna Jain, Mamta Bhardwaj, and Amit Sharma. 2023. “Diabetes Mellitus in Acute Exacerbation of Chronic Obstructive Pulmonary Disease – the Tip of the Iceberg”. Monaldi Archives for Chest Disease, November. https://doi.org/10.4081/monaldi.2023.2776.
Copyright (c) 2023 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Josuel Ora, Emanuela Prendi, Maria Laura Attinà, Mario Cazzola, Luigino Calzetta, Paola Rogliani, Efficacy of respiratory tele-rehabilitation in COPD patients: Systematic review and meta-analysis , Monaldi Archives for Chest Disease: Vol. 92 No. 4 (2022)
- Giorgio E. Polistina, Francesca Simioli, Pasquale Imitazione, Maurizia Lanza, Anna Annunziata, Giuseppe Fiorentino, Different presentation of pulmonary parenchymal disruption in COVID-19 pneumonia. Case series of Sub-Intensive Care Unit in Naples, Italy , Monaldi Archives for Chest Disease: Vol. 90 No. 4 (2020)
- C. Carbonelli, A. Roggeri, A. Cavazza, M. Zompatori, L. Zucchi, Relapsing bronchiolitis obliterans organising pneumonia and chronic sarcoidosis in an atopic asthmatic patient , Monaldi Archives for Chest Disease: Vol. 69 No. 1 (2008): Pulmonary series
- Muhammed Kurt, Udo Boeken, Jens Litmathe, Peter Feindt, Emmeran Gams, Oxygenation failure after cardiac surgery: early re-intubation versus treatment by nasal continuous positive airway pressure (NCPAP) or non-invasive positive pressure ventilation (NPPV) , Monaldi Archives for Chest Disease: Vol. 70 No. 2 (2008): Cardiac series
- A. Srinivasan, R. Agarwal, Cardiovocal syndrome , Monaldi Archives for Chest Disease: Vol. 75 No. 4 (2011): Pulmonary series
- Dimitrios Papadopoulos, Panagiotis Misthos, Maria Chorti, Vlasios Skopas, Alexandra Nakou, Napoleon Karagianidis, Achilleas Lioulias, Vasiliki Filaditaki, Unilateral pulmonary hypoplasia in an adult patient , Monaldi Archives for Chest Disease: Vol. 88 No. 1 (2018)
- Olga Vriz, Rodolfo Citro, Stefano Martina, Franco Pertoldi, Daniela Pavan, Francesco Antonini-Canterin, Eduardo Bossone, Tako-tsubo syndrome and hypovolemia , Monaldi Archives for Chest Disease: Vol. 72 No. 3 (2009): Cardiac series
- Mamta Singh, Kunal Deokar, Bibhuti Prassan Sinha, Monika Keena, Govind Desai, Ocular manifestations of common pulmonary diseases: a narrative review , Monaldi Archives for Chest Disease: Vol. 94 No. 1 (2024)
- Vipul Prakash, Arjun Kumar, Lokesh Kumar Saini, Barun Kumar, Girish Sindhwani, Prakhar Sharma, Ruchi Dua, Ravi Gupta, Mayank Mishra, Proportion of sleep-related breathing disorders and their association with echocardiographic parameters in stable patients with chronic obstructive pulmonary disease: a cross-sectional observational exploratory study , Monaldi Archives for Chest Disease: Early Access
- Dario Amore, Umberto Caterino, Dino Casazza, Riccardo Ievoli, Pasquale Imitazione, Alessandro Saglia, Alessandro Izzo, Marco Rispoli, Carlo Curcio, Persistent alveolar air leak following pulmonary lobectomy: an old problem in a modern era , Monaldi Archives for Chest Disease: Vol. 93 No. 4 (2023)
<< < 15 16 17 18 19 20 21 22 23 24 > >>
You may also start an advanced similarity search for this article.
