https://doi.org/10.4081/monaldi.2023.2778

PDL1 and molecular biomarkers expression in non-small cell lung cancer in Tunisian patients

Early Access
Submitted: September 12, 2023
Accepted: October 19, 2023
Published: November 3, 2023
Lung carcinoma; molecular profile; EGFR; PD-L1
Abstract Views: 643
PDF_early view: 459
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Authors

Yoldez Houcine
https://orcid.org/0000-0002-7155-5519
Pathology Department, Salah Azaiz Institute, Tunis; Faculty of Medicine of Tunis, El Manar University, Tunis, Tunisia.
Chirine Moussa
chirine.moussa@fmt.utm.tn
https://orcid.org/0000-0002-8123-9843
Faculty of Medicine of Tunis, El Manar University, Tunis; Pneumology Department 1, Abderrahmen Mami Hospital, Ariana, Tunisia.
Ahmed Ben Abdelaziz
Epidemiology and Statistics Department, Farhat Hached Hospital, Sousse, Tunisia.
Aida Ayadi
Faculty of Medicine of Tunis, El Manar University, Tunis; Pathology Department, Abderrahmen Mami Hospital, Ariana, Tunisia.

In cancer treatment, programmed death-1 (PD-1) and programmed death ligand-1 (PD-L1) inhibitors are thriving. Activated T lymphocytes expressed PD-1, it works with its ligand PD-L1 to limit T lymphocyte activation and prevent autoimmune disease. The expression of molecular biomarkers and PD-L1 in lung cancer determines the appropriate treatment strategy for patients with lung cancer. The purpose of this study was to look at the prevalence of molecular biomarkers and PD-L1 expression in a large group of Tunisian patients with advanced non-small cell lung cancer. We conducted an observational retrospective study in which medical/treatment history data were extracted retrospectively from medical records and archived tissue samples between January 1st 2019 and December 31st 2021. We gathered 157 patients who had recently been diagnosed with non-small cell lung carcinoma. In 36.9%of the cases, there was no molecular genotyping. EGFR (28.6%), KRAS (5.73%), and ALK gene rearrangement were the most common genotyping mutations (3.8%). ROS1 rearrangement was not present. There was a link between EGFR and gender, HER and age, and KRAS and biopsy tissue origin. Six of the tested cases with PD-L1 met the cut-off (³50%). PD-L1 positivity was more common in solid type adenocarcinoma (1.9%) than in acinar or papillary adenocarcinoma. There were no significant differences in PD-L1 expression across clinical and demographic parameters. High PD-L1 expression and molecular abnormalities were found in 1 case of EGFR, 1 case of BRAF, and 1 case of KRAS (3 cases). All of the other specimens with abnormalities had a PD-L1 <50%. ALK, ROS1, BRAF, KRAS, and MET were found to be significantly associated with PD-L1 expression. Our study is one of the country's largest, describing a large panel of biomarkers and their clinicopathologic/histopathologic associations in Tunisian lung cancer patients. We have the same molecular profile as European patients with an EGFR mutation, which is not the most common genotype abnormality in Tunisian patients. There is only one mutation at any given time. The expression of PD-L1 is determined by the histologic type and the origin of the biopsy tissue.

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How to Cite

Houcine, Yoldez, Chirine Moussa, Ahmed Ben Abdelaziz, and Aida Ayadi. 2023. “PDL1 and Molecular Biomarkers Expression in Non-Small Cell Lung Cancer in Tunisian Patients”. Monaldi Archives for Chest Disease, November. https://doi.org/10.4081/monaldi.2023.2778.
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