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Multidrug-resistant tuberculosis in Iran: a multicenter study
The worldwide incidence of multi-drug-resistant tuberculosis (MDR-TB) is rapidly increasing, and it has emerged as a pressing public health issue in Iran. Nevertheless, there is a scarcity of up-to-date research on the prevalence of MDR-TB in individuals with pulmonary TB in the country. In this cross-sectional study, we gathered a total of 1216 respiratory samples, each corresponding to a unique patient, from five distinct regional TB laboratories in Iran. We identified clinical isolates as Mycobacterium tuberculosis using the IS6110-based PCR assay and Xpert MTB/RIF. Drug susceptibility testing (DST) was conducted using the conventional proportion method. Out of the collected specimens, 448 tested positive for M. tuberculosis. Among these isolates, 445 (99.4%) exhibited susceptibility to the tested drugs, while 3 (0.6%) were found to be MDR. The findings from this recent study indicate that the prevalence of MDR in Iran stands at 0.6%. The absence of recently approved treatment protocols in various regions of Iran, along with inadequately equipped laboratories lacking DST capabilities, could contribute significantly to the rise in TB/MDR-TB prevalence in Iran. Therefore, the implementation of enhanced treatment management strategies and the adoption of innovative technologies are essential steps towards improving the current situation.
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Ethics Approval
The study was approved by the Ethics Committee of the Shahid Beheshti University of Medical Sciences, Tehran, Iran (IR.SBMU.MSP.REC.1400.677).How to Cite
Khelghati, Fatemeh, Fatemeh Nasirpour Seilakhori, Mehdi Goudarzi, Shima Malekloo, Amir Hashem Shahidi Bonjar, Hossein Goudarzi, and Mohammad Javad Nasiri. 2024. “Multidrug-Resistant Tuberculosis in Iran: A Multicenter Study”. Monaldi Archives for Chest Disease, January. https://doi.org/10.4081/monaldi.2024.2844.
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