https://doi.org/10.4081/monaldi.2024.2852
Tailored treatment for tuberculosis in transgender individuals: a call for a patient-centered approach from a large Italian cohort
Published: January 11, 2024
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Tuberculosis (TB) diagnosis and management in special populations remain challenging. Data about TB and transgender individuals is scarce, and strategies aimed at reducing the TB burden in this at-risk group are needed. We conducted an observational monocentric study from a national reference center for TB, including transgender individuals with active TB in a low-TB burden country (Italy), over 34 years (1990-2023). Sixty-six transgender males and two transgender females (median age 30 years, interquartile range 26-38 years, 65 migrants) were included. Most patients (38/66, 57.6%) lived in poor social conditions. 65.2% (43/66) of patients were people living with HIV. Multidrug- and rifampicin-resistant tuberculosis and isoniazid-resistant TB were diagnosed in five (7.6%) and three (4.5%) patients, respectively. The overall treatment success rate was 72.7% (48/66 patients), with differences observed according to social conditions. Our study highlights the need for a tailored approach to increase treatment success in this at-risk population.
World Health Organization. Global tuberculosis report 2022. Available from: https://iris.who.int/bitstream/handle/10665/363752/9789240061729-eng.pdf?sequence=1.
Matucci T, Riccardi N, Occhineri S, et al. Treatment of latent tuberculosis infection in incarcerated people: a systematic review. Clin Microbiol Infect 2023;29:714-21.
DOI: https://doi.org/10.1016/j.cmi.2023.02.016
Riccardi N, Antonello RM, Ferrarese M, et al. Tuberculosis in migrants: epidemiology, resistance and outcome in Milan, Italy. Infect Dis 2023;55:543-50.
DOI: https://doi.org/10.1080/23744235.2023.2217912
Shah SA, Qayyum S, Baig S, et al. Results of community-based TB and HIV screening among transgender women and male sex workers in Pakistan. PLOS Glob Public Health 2023;3:e0000913.
DOI: https://doi.org/10.1371/journal.pgph.0000913
Pareek M, Greenaway C, Noori T, et al. The impact of migration on tuberculosis epidemiology and control in high-income countries: a review. BMC Med 2016;14:48.
DOI: https://doi.org/10.1186/s12916-016-0595-5
Commission of the European Communities. Commission decision of 28 April 2008 amending decision 2002/253/EC laying down case definitions for reporting communicable diseases to the Community network under decision no 2119/98/EC of the European Parliament and of the Council. In: Official Journal, L159/46, 18/06/2008.
Getahun H, Matteelli A, Chaisson RE, Raviglione M. Latent mycobacterium tuberculosis infection. N Engl J Med 2015;372:2127-35.
DOI: https://doi.org/10.1056/NEJMra1405427
World Health Organization. WHO consolidated guidelines on tuberculosis. Module 4: treatment - drug-resistant tuberculosis treatment, 2022 update. Available from: https://iris.who.int/bitstream/handle/10665/365308/9789240063129-eng.pdf?sequence=1.
Canetti D, Antonello RM, Saderi L, et al. Impact of SARS-CoV-2 infection on tuberculosis outcome and follow-up in Italy during the first COVID-19 pandemic wave: a nationwide online survey. Infez Med 2022;30:418-26.
DOI: https://doi.org/10.53854/liim-3003-10
Morrison H, Perrin F, Dedicoat M, et al. Impact of COVID-19 on NHS tuberculosis services: Results of a UK-wide survey. J Infect 2023;87:59-61.
DOI: https://doi.org/10.1016/j.jinf.2023.04.004
Ethics Approval
The study received ethical approval n. 578–112,018 from the ethical committee of ASST Niguarda Ca′ Granda in Milan (Italy) and it was conducted in agreement with the Declaration of Helsinki (1964) and its later amendments.How to Cite
Riccardi, Niccolò, Roberta Maria Antonello, Maurizio Ferrarese, Alice Repossi, Laura Saderi, Giovanni Fumagalli, Giorgio Besozzi, Giovanni Sotgiu, and Luigi Codecasa. 2024. “Tailored Treatment for Tuberculosis in Transgender Individuals: A Call for a Patient-Centered Approach from a Large Italian Cohort”. Monaldi Archives for Chest Disease, January. https://doi.org/10.4081/monaldi.2024.2852.
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