https://doi.org/10.4081/monaldi.2024.2852
Tailored treatment for tuberculosis in transgender individuals: a call for a patient-centered approach from a large Italian cohort
Published: January 11, 2024
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Tuberculosis (TB) diagnosis and management in special populations remain challenging. Data about TB and transgender individuals is scarce, and strategies aimed at reducing the TB burden in this at-risk group are needed. We conducted an observational monocentric study from a national reference center for TB, including transgender individuals with active TB in a low-TB burden country (Italy), over 34 years (1990-2023). Sixty-six transgender males and two transgender females (median age 30 years, interquartile range 26-38 years, 65 migrants) were included. Most patients (38/66, 57.6%) lived in poor social conditions. 65.2% (43/66) of patients were people living with HIV. Multidrug- and rifampicin-resistant tuberculosis and isoniazid-resistant TB were diagnosed in five (7.6%) and three (4.5%) patients, respectively. The overall treatment success rate was 72.7% (48/66 patients), with differences observed according to social conditions. Our study highlights the need for a tailored approach to increase treatment success in this at-risk population.
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Ethics Approval
The study received ethical approval n. 578–112,018 from the ethical committee of ASST Niguarda Ca′ Granda in Milan (Italy) and it was conducted in agreement with the Declaration of Helsinki (1964) and its later amendments.How to Cite
Riccardi, Niccolò, Roberta Maria Antonello, Maurizio Ferrarese, Alice Repossi, Laura Saderi, Giovanni Fumagalli, Giorgio Besozzi, Giovanni Sotgiu, and Luigi Codecasa. 2024. “Tailored Treatment for Tuberculosis in Transgender Individuals: A Call for a Patient-Centered Approach from a Large Italian Cohort”. Monaldi Archives for Chest Disease, January. https://doi.org/10.4081/monaldi.2024.2852.
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