https://doi.org/10.4081/monaldi.2024.2907
Transplantation of heterozygous familial hypercholesterolemia living donor liver resulting in early myocardial infarction: a possible dangerous link
Submitted: January 9, 2024
Accepted: January 14, 2024
Published: January 16, 2024
Accepted: January 14, 2024
Abstract Views: 458
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Living donor liver transplantation (LDLT) is a lifesaving procedure that is often curative for several liver diseases. Familial hypercholesterolemia (FH) is a metabolic disease that results from an autosomal dominant mutation in the low-density lipoprotein receptor; yet, young patients with FH can live years without detection. Herein, we report a case of a patient who developed early myocardial infarction (MI) after having a transplant from a donor with undetected heterozygous FH. This was a 67-year-old female with non-alcoholic steatohepatitis-related liver cirrhosis, free from coronary artery disease, who underwent LDLT from her daughter, a 45-year-old female with no past medical history. One year post-transplant, she presented with an acute MI with a large atherosclerotic burden. Genetic analysis confirmed heterozygous FH in the donor but not in the recipient. This case emphasizes the importance of incorporating a thorough clinical history and lipid profile into pre-transplant testing for both the recipient and donor, as well as aggressive lipid-lowering therapy post-transplantation to avoid cardiovascular complications.
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Ethics Approval
The study was approved by the office of research affairs and the Ethical Committee of our Institution (approval number: RAC 2191111).How to Cite
Kholaif, Naji, Lin Batha, Isra Elmahi, Sulaiman Alnaser, Sultan Alzaher, Norah Almallohi, Mosaad Alhussein, Dana Alhalees, and Ahmed Alshehri. 2024. “Transplantation of Heterozygous Familial Hypercholesterolemia Living Donor Liver Resulting in Early Myocardial Infarction: A Possible Dangerous Link”. Monaldi Archives for Chest Disease, January. https://doi.org/10.4081/monaldi.2024.2907.
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