https://doi.org/10.4081/monaldi.2024.3004

A bibliometric analysis of cystic fibrosis transmembrane conductance regulators

Early Access
Submitted: March 27, 2024
Accepted: June 3, 2024
Published: July 24, 2024
Cystic fibrosis, CFTR protein, CFTR modulators, bibliometric analysis, scopus
Abstract Views: 603
PDF_EARLY VIEW: 146
SUPPLEMENTARY MATERIAL: 19
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Authors

Bashar Araiqat
bbaraiqat189@med.just.edu.jo
https://orcid.org/0000-0003-4728-6707
Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Sebawe Syaj
Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Aseel Al-Khatib
Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Nour Al-Bzour
Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Narmine Hussein
Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Sarah Aqel
https://orcid.org/0009-0003-4590-509X
Medical Research Center, Hamad Medical Corporation, Doha, Qatar.
Jamil Ahmad
Department of Urology, Hamad Medical Corporation, Doha, Qatar.

Cystic fibrosis (CF), a multisystem disease primarily affecting the lungs, arises due to pathogenic mutations in the CF transmembrane conductance regulator (CFTR) gene. This study embarked on a bibliometric analysis to survey the use of CFTR modulators in CF treatment. Utilizing the Scopus database, a comprehensive search was executed, incorporating terms related to CF and CFTR modulators. Various document types up to July 19, 2023, were included, with citation counts forming the basis of our analyses. Trends, contributor countries, leading institutions, top authors, journals, keywords, and annual citation trends were evaluated. Our search retrieved 2317 records, predominantly articles. The United States dominated in both publications and citations, followed by the United Kingdom. The University of Alabama, Birmingham, and Vertex Pharmaceuticals, Boston, were among the top institutions. Rowe S.M. was identified as a top-cited author. The Journal of Cystic Fibrosis emerged as the leading journal in terms of publication volume, while the New England Journal of Medicine had the highest citation count. The most-cited article addressed a CFTR potentiator's efficacy in patients with the G551D mutation. The keyword "Cystic fibrosis" appeared most frequently. This bibliometric analysis underscores the significant research focus on CF, especially concerning CFTR modulators. The results highlight the pivotal role of certain countries, institutions, authors, and journals in the progression of CF research, offering insights into current trends and future research directions.

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How to Cite

Araiqat, Bashar, Sebawe Syaj, Aseel Al-Khatib, Nour Al-Bzour, Narmine Hussein, Sarah Aqel, and Jamil Ahmad. 2024. “A Bibliometric Analysis of Cystic Fibrosis Transmembrane Conductance Regulators”. Monaldi Archives for Chest Disease, July. https://doi.org/10.4081/monaldi.2024.3004.
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