https://doi.org/10.4081/monaldi.2024.3005
Small airway involvement in severe asthma: how common is it and what are its implications?
Submitted: March 27, 2024
Accepted: September 26, 2024
Published: December 4, 2024
Accepted: September 26, 2024
Abstract Views: 414
PDF_EARLY VIEW: 103
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Asthma is a prevalent chronic respiratory disease affecting all age groups globally, causing significant morbidity and mortality. Small airway involvement, often undetected by traditional spirometry, has emerged as a critical aspect of asthma pathophysiology, especially in severe cases. This retrospective observational study aimed to assess small airway dysfunction using impulse oscillometry (IOS) in 94 severe asthma patients. Results indicated that 27.3% of patients had small airway obstruction. While spirometry showed no statistical differences between groups, IOS parameters were significantly different, highlighting its sensitivity in detecting small airway disease. Patients with small airway involvement exhibited poorer asthma control, emphasizing the clinical relevance of identifying and addressing small airway dysfunction. The study underscores the need for comprehensive evaluation tools like IOS alongside spirometry, especially in severe asthma management. Further large-scale studies are warranted to validate IOS's utility in optimizing therapeutic strategies and improving asthma control, particularly in resource-limited settings. Recognizing and addressing small airway involvement could lead to individualized management approaches and better outcomes in severe asthma patients.
Hekking PPW, Wener RR, Amelink M, et al. The prevalence of severe refractory asthma. J Allergy Clin Immunol 2015;135:896-902.
DOI: https://doi.org/10.1016/j.jaci.2014.08.042
Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J 2014;43:343-73.
DOI: https://doi.org/10.1183/09031936.00202013
van der Wiel E, ten Hacken NHT, Postma DS, van den Berge M. Small-airways dysfunction associates with respiratory symptoms and clinical features of asthma: a systematic review. J Allergy Clin Immunol 2013;131:646-57.
DOI: https://doi.org/10.1016/j.jaci.2012.12.1567
Burgel PR. The role of small airways in obstructive airway diseases. Eur Respir Rev 2011;20:23-33.
DOI: https://doi.org/10.1183/09059180.00010410
Leach CL, Davidson PJ, Hasselquist BE, Boudreau RJ. Lung deposition of hydrofluoroalkane-134a beclomethasone is greater than that of chlorofluorocarbon fluticasone and chlorofluorocarbon beclomethasone: a cross-over study in healthy volunteers. Chest 2002;122:510-6.
DOI: https://doi.org/10.1378/chest.122.2.510
Agrawal A, Desiraju K. Impulse oscillometry: the state-of-art for lung function testing. Lung India 2016;33:410-6.
DOI: https://doi.org/10.4103/0970-2113.184875
Perez T. Is it really time to look at distal airways to improve asthma phenotyping and treatment? Eur Respir J 2011;38:1252-4.
DOI: https://doi.org/10.1183/09031936.00067711
Usmani OS, Singh D, Spinola M, et al. The prevalence of small airways disease in adult asthma: a systematic literature review. Respir Med 2016;116:19-27.
DOI: https://doi.org/10.1016/j.rmed.2016.05.006
Carr TF, Altisheh R, Zitt M. Small airways disease and severe asthma. World Allergy Organ J 2017;10:20.
DOI: https://doi.org/10.1186/s40413-017-0153-4
10. Scichilone N, Battaglia S, Olivieri D, Bellia V. The role of small airways in monitoring the response to asthma treatment: what is beyond FEV1? Allergy 2009;64:1563-9.
DOI: https://doi.org/10.1111/j.1398-9995.2009.02139.x
Nikkhah M, Amra B, Eshaghian A, et al. Comparison of impulse osillometry system and spirometry for diagnosis of obstructive lung disorders. Tanaffos 2011;10:19-25.
Postma DS, Brightling C, Baldi S, et al. Exploring the relevance and extent of small airways dysfunction in asthma (ATLANTIS): baseline data from a prospective cohort study. Lancet Respir Med 2019;7:402-16.
DOI: https://doi.org/10.1016/S2213-2600(19)30049-9
Mousa H, Kamal E. Impulse oscillation system versus spirometry in assessment of obstructive airway diseases. Egypt J Chest Dis Tuberc 2018;67:106-12.
DOI: https://doi.org/10.4103/ejcdt.ejcdt_3_18
Cottini M, Licini A, Lombardi C, et al. Small airway dysfunction and poor asthma control: a dangerous liaison. Clin Mol Allergy 2021;19:7.
DOI: https://doi.org/10.1186/s12948-021-00147-8
Cohen J, Douma WR, ten Hacken NHT, et al. Ciclesonide improves measures of small airway involvement in asthma. Eur Respir J 2008;31:1213-20.
DOI: https://doi.org/10.1183/09031936.00082407
Ethics Approval
Approved by the Ethics and Scientific Committee (Ref. 29/MERB/2019) as per the Declaration of Helsinki.How to Cite
Talwar, Dhruv, Sourabh Pahuja, Deepak Prajapat, Kanishka Kumar, Anupam Prakash, and Deepak Talwar. 2024. “Small Airway Involvement in Severe Asthma: How Common Is It and What Are Its Implications?”. Monaldi Archives for Chest Disease, December. https://doi.org/10.4081/monaldi.2024.3005.
Copyright (c) 2024 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Kamal Kant Sahu, Ajay Kumar Mishra, Amos Lal, COVID-2019: update on epidemiology, disease spread and management , Monaldi Archives for Chest Disease: Vol. 90 No. 1 (2020)
- Nipun Malhotra, Nitesh Gupta, Somya Ish, Pranav Ish, COVID-19 in intensive care. Some necessary steps for health care workers , Monaldi Archives for Chest Disease: Vol. 90 No. 1 (2020)
- Vasiliki Epameinondas Georgakopoulou, Dimitrios Mermigkis, Despoina Melemeni, Aikaterini Gkoufa, Christos Damaskos, Nikolaos Garmpis, Anna Garmpi, Nikolaos Trakas, Xanthi Tsiafaki, Cytomegalovirus pneumonia in an immunocompetent host with primary ciliary dyskinesia: A case report , Monaldi Archives for Chest Disease: Vol. 91 No. 3 (2021)
- Konstantinos Kapriniotis, Angelina Bania, Savvas Lampridis, Georgios Geropoulos, Sofoklis Mitsos, Fleur Monk, David A. Moore, Nikolaos Panagiotopoulos, Metastatic mandibular ameloblastoma of the lung ten years after primary resection: A rare case report , Monaldi Archives for Chest Disease: Vol. 91 No. 2 (2021)
- Thomas Galasso, Lorenzo Corbetta, Laura Mancino, Lucio Michieletto, Loris Ceron, Statistical approach to mediastinal staging in NSCLC with M.E.S.S.i.a. software , Monaldi Archives for Chest Disease: Vol. 89 No. 3 (2019)
- Barun Kumar, Ashwin Kodliwadmath, Amar Upadhyay, Anupam Singh, Nanda N, Apparently normal epicardial coronaries in a patient with inferior wall myocardial infarction on the background of mild coronavirus disease-2019: take a second look! , Monaldi Archives for Chest Disease: Vol. 91 No. 3 (2021)
- Stefano Maffè, Pierfranco Dellavesa, Paola Paffoni, Luca Bergamasco, Marisa Arrondini, Stefano Valentini, Emanuela Facchini, Eleonora Prenna, Lara Baduena, Giulia Careri, Nicolò Franchetti Pardo, Umberto Parravicini, Takotsubo syndrome and pheochromocytoma: an insidious combination , Monaldi Archives for Chest Disease: Vol. 91 No. 3 (2021)
- Immacolata Ambrosino, Elena Barbagelata, Elena Ortona, Anna Ruggieri, Grace Massiah, Orazio Valerio Giannico, Cecilia Politi, Anna Maria Moretti, Gender differences in patients with COVID-19: a narrative review , Monaldi Archives for Chest Disease: Vol. 90 No. 2 (2020)
- Elvira-Markella Antonogiannaki, Athanasia Proklou, Dimitrios Tamiolakis, Evangelia Vassalou, Eumorfia Kondili, Invasive Aspergillus tracheobronchitis in a patient with hairy cell leukemia and previous Plasmodium falciparum infection , Monaldi Archives for Chest Disease: Vol. 89 No. 2 (2019)
- Soundariya Krishnamurthy, Yuvarajan Sivagnaname, Gokul Chandu Gumallapu, Identification of subclinical cognitive impairment in chronic obstructive pulmonary disease using auditory P300 event related potential , Monaldi Archives for Chest Disease: Vol. 89 No. 2 (2019)
<< < 59 60 61 62 63 64 65 66 > >>
You may also start an advanced similarity search for this article.
