https://doi.org/10.4081/monaldi.2024.3054

Additional yield of transbronchial cryo-node biopsy over endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal lesions at a tertiary care center in India (COLD-FORCEPS-2 study)

Early Access
Submitted: May 12, 2024
Accepted: June 3, 2024
Published: July 24, 2024
Lymph nodes, mediastinum, endoscopic ultrasound-guided fine needle aspiration/methods, ultrasonography, interventional
Abstract Views: 269
PDF_EARLY VIEW: 69
SUPPLEMENTARY MATERIAL: 31
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Manu Madan
Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, Delhi, India.
Rohit Kumar
Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, Delhi, India.
Pranav Ish
Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, Delhi, India.
Yash Kedia
https://orcid.org/0000-0002-0453-0039
Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, Delhi, India.
AJ Mahendran
SpR Transplant (lung) Medicine, Royal Brompton and Harefield Medicine, London, United Kingdom.
Rajnish Kaushik
Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, Delhi, India.
Neeraj Kumar Gupta
Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, Delhi, India.
Nitesh Gupta
niteshgupta2107@gmail.com
Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, Delhi, India.

Endobronchial ultrasound (EBUS)-guided mediastinal cryobiopsy is a new modality for sampling mediastinal lymph nodes. The data regarding the diagnostic yield and utility of mediastinal cryobiopsy is still limited. Consecutive patients who were undergoing EBUS-guided transbronchial needle aspiration (EBUS-TBNA) were recruited in this study. We subjected the enrolled patients to EBUS-guided mediastinal cryobiopsy after obtaining their informed consent. The final diagnosis was made with a clinical-pathological-radiological assessment and clinical-radiological follow-up. A total of 101 patients were enrolled in the study. Adequacy in sampling achieved in EBUS-TBNA was 92.07%, compared to 98.01% achieved in EBUS-TBNA with mediastinal cryobiopsy. Diagnostic yields achieved in EBUS-TBNA and EBUS-TBNA with mediastinal cryobiopsy were 67.32% and 86.13%, respectively (p=0.001). EBUS patterns failed to predict the utility of mediastinal crobiopsy. No significant complications were observed. To conclude, EBUS-guided mediastinal cryobiopsy improves yield in patients undergoing EBUS-TBNA.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

Crossref
Scopus
Google Scholar
Europe PMC
Madan K, Mohan A, Ayub II, et al. Initial experience with endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) from a tuberculosis endemic population. J Bronchology Interv Pulmonol 2014;21:208-14. DOI: https://doi.org/10.1097/LBR.0000000000000080
Lentz RJ, Argento AC, Colby TV, et al. Transbronchial cryobiopsy for diffuse parenchymal lung disease: a state-of-the-art review of procedural techniques, current evidence, and future challenges. J Thorac Dis 2017;9:2186-203. DOI: https://doi.org/10.21037/jtd.2017.06.96
Zhang J, Guo JR, Huang ZS, et al. Transbronchial mediastinal cryobiopsy in the diagnosis of mediastinal lesions: a randomized trial. Eur Respir J 2021;58:2100055. DOI: https://doi.org/10.1183/13993003.00055-2021
Fan Y, Zhang AM, Wu XL, et al. Transbronchial needle aspiration combined with cryobiopsy in the diagnosis of mediastinal diseases: a multicentre, open-label, randomised trial. Lancet Respir Med 2023;11:256-64. DOI: https://doi.org/10.1016/S2213-2600(22)00392-7
Madan M, Mahendran AJ, Kumar R, et al. Comparative yield of transbronchial cryo-nodal biopsy, transbronchial intra-nodal forceps biopsy, and transbronchial needle aspiration for mediastinal lesions at a tertiary care center in India (COLD-FORCEPS study). Monaldi Arch Chest Dis 2024. doi: 10.4081/monaldi.2024.2813. Online ahead of print. DOI: https://doi.org/10.4081/monaldi.2024.2813
Zhang Z, Li S, Bao Y. Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy versus endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal disorders: a meta-analysis. Respiration 2024. doi: 10.1159/000538609. Online ahead of print. DOI: https://doi.org/10.1159/000538609
Cheng TL, Huang ZS, Zhang J, et al. Comparison of cryobiopsy and forceps biopsy for the diagnosis of mediastinal lesions: a randomised clinical trial. Pulmonology 2024;S2531-0437(23)00240-4. DOI: https://doi.org/10.1016/j.pulmoe.2023.12.002

Ethics Approval

Institute ethical committee clearance taken vide S. No. IEC/VMMC/SJH/Project 2024-01/429 dated 4 March 2024.

How to Cite

Madan, Manu, Rohit Kumar, Pranav Ish, Yash Kedia, AJ Mahendran, Rajnish Kaushik, Neeraj Kumar Gupta, and Nitesh Gupta. 2024. “Additional Yield of Transbronchial Cryo-Node Biopsy over Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for Mediastinal Lesions at a Tertiary Care Center in India (COLD-FORCEPS-2 Study)”. Monaldi Archives for Chest Disease, July. https://doi.org/10.4081/monaldi.2024.3054.
Copyright (c) 2024 The Author(s) Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.


Similar Articles

<< < 6 7 8 9 10 11 12 13 14 15 > >> 

You may also start an advanced similarity search for this article.