https://doi.org/10.4081/monaldi.2024.3054

Additional yield of transbronchial cryo-node biopsy over endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal lesions at a tertiary care center in India (COLD-FORCEPS-2 study)

Early Access
Submitted: May 12, 2024
Accepted: June 3, 2024
Published: July 24, 2024
Lymph nodes, mediastinum, endoscopic ultrasound-guided fine needle aspiration/methods, ultrasonography, interventional
Abstract Views: 269
PDF_EARLY VIEW: 69
SUPPLEMENTARY MATERIAL: 31
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Authors

Manu Madan
Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, Delhi, India.
Rohit Kumar
Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, Delhi, India.
Pranav Ish
Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, Delhi, India.
Yash Kedia
https://orcid.org/0000-0002-0453-0039
Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, Delhi, India.
AJ Mahendran
SpR Transplant (lung) Medicine, Royal Brompton and Harefield Medicine, London, United Kingdom.
Rajnish Kaushik
Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, Delhi, India.
Neeraj Kumar Gupta
Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, Delhi, India.
Nitesh Gupta
niteshgupta2107@gmail.com
Department of Pulmonary, Critical Care and Sleep Medicine, VMMC and Safdarjung Hospital, Delhi, India.

Endobronchial ultrasound (EBUS)-guided mediastinal cryobiopsy is a new modality for sampling mediastinal lymph nodes. The data regarding the diagnostic yield and utility of mediastinal cryobiopsy is still limited. Consecutive patients who were undergoing EBUS-guided transbronchial needle aspiration (EBUS-TBNA) were recruited in this study. We subjected the enrolled patients to EBUS-guided mediastinal cryobiopsy after obtaining their informed consent. The final diagnosis was made with a clinical-pathological-radiological assessment and clinical-radiological follow-up. A total of 101 patients were enrolled in the study. Adequacy in sampling achieved in EBUS-TBNA was 92.07%, compared to 98.01% achieved in EBUS-TBNA with mediastinal cryobiopsy. Diagnostic yields achieved in EBUS-TBNA and EBUS-TBNA with mediastinal cryobiopsy were 67.32% and 86.13%, respectively (p=0.001). EBUS patterns failed to predict the utility of mediastinal crobiopsy. No significant complications were observed. To conclude, EBUS-guided mediastinal cryobiopsy improves yield in patients undergoing EBUS-TBNA.

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Madan M, Mahendran AJ, Kumar R, et al. Comparative yield of transbronchial cryo-nodal biopsy, transbronchial intra-nodal forceps biopsy, and transbronchial needle aspiration for mediastinal lesions at a tertiary care center in India (COLD-FORCEPS study). Monaldi Arch Chest Dis 2024. doi: 10.4081/monaldi.2024.2813. Online ahead of print. DOI: https://doi.org/10.4081/monaldi.2024.2813
Zhang Z, Li S, Bao Y. Endobronchial ultrasound-guided transbronchial mediastinal cryobiopsy versus endobronchial ultrasound-guided transbronchial needle aspiration for mediastinal disorders: a meta-analysis. Respiration 2024. doi: 10.1159/000538609. Online ahead of print. DOI: https://doi.org/10.1159/000538609
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Ethics Approval

Institute ethical committee clearance taken vide S. No. IEC/VMMC/SJH/Project 2024-01/429 dated 4 March 2024.

How to Cite

Madan, Manu, Rohit Kumar, Pranav Ish, Yash Kedia, AJ Mahendran, Rajnish Kaushik, Neeraj Kumar Gupta, and Nitesh Gupta. 2024. “Additional Yield of Transbronchial Cryo-Node Biopsy over Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration for Mediastinal Lesions at a Tertiary Care Center in India (COLD-FORCEPS-2 Study)”. Monaldi Archives for Chest Disease, July. https://doi.org/10.4081/monaldi.2024.3054.
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